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DENND1B
DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1. Structure The protein has tripartite DENN domain at N-terminal. Functions The protein is a guanine nucleotide exchange factor for RAB35. Clinical significance The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wh .... The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis. Variants of this gene are also associated with obesity in both humans and dogs. References Genes on human chromosome 1 {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Pulmonary Aspergillosis
Chronic pulmonary aspergillosis is a long-term fungal infection caused by members of the genus ''Aspergillus''—most commonly ''Aspergillus'' ''fumigatus''. The term describes several disease presentations with considerable overlap, ranging from an aspergilloma—a clump of ''Aspergillus'' mold in the lungs—through to a subacute, invasive form known as chronic necrotizing pulmonary aspergillosis which affects people whose immune system is weakened. Many people affected by chronic pulmonary aspergillosis have an underlying lung disease, most commonly tuberculosis, allergic bronchopulmonary aspergillosis, asthma, or lung cancer. Classification Chronic pulmonary aspergillosis as a term encompasses a number of different presentations of varying severity. There is considerable overlap between disease forms which adds to confusion during diagnosis. The primary differentiation comes from radiological findings and serology. Aspergilloma An aspergilloma is a fungus ball compos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 1
Chromosome 1 is the designation for the largest human chromosome. Humans have two copies of chromosome 1, as they do with all of the autosomes, which are the non-sex chromosomes. Chromosome 1 spans about 249 million nucleotide base pairs, which are the basic units of information for DNA.http://vega.sanger.ac.uk/Homo_sapiens/mapview?chr=1 Chromosome size and number of genes derived from this database, retrieved 2012-03-11. It represents about 8% of the total DNA in human cells. It was the last completed chromosome, sequenced two decades after the beginning of the Human Genome Project. Genes Number of genes The following are some of the gene count estimates of human chromosome 1. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) takes an extremely conservative strategy. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Gene
Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are great apes characterized by their hairlessness, bipedalism, and high intelligence. Humans have large brains, enabling more advanced cognitive skills that facilitate successful adaptation to varied environments, development of sophisticated tools, and formation of complex social structures and civilizations. Humans are highly social, with individual humans tending to belong to a multi-layered network of distinct social groups — from families and peer groups to corporations and political states. As such, social interactions between humans have established a wide variety of values, social norms, languages, and traditions (collectively termed institutions), each of which bolsters human society. Humans are also highly curious: the desire to understand and influence phenomena has motivated humanity's development of s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-terminal
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amine group is bonded to the carboxylic group of another amino acid, making it a chain. That leaves a free carboxylic group at one end of the peptide, called the C-terminus, and a free amine group on the other end called the N-terminus. By convention, peptide sequences are written N-terminus to C-terminus, left to right (in LTR writing systems). This correlates the translation direction to the text direction, because when a protein is translated from messenger RNA, it is created from the N-terminus to the C-terminus, as amino acids are added to the carboxyl end of the protein. Chemistry Each amino acid has an amine group and a carboxylic group. Amino acids link to one another by peptide bonds which form through a dehydration reaction that j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guanine Nucleotide Exchange Factor
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase. Function Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small GTPases act as molecular switches in intracellular signaling pathways and have many downstream targets. The most well-known GTPases comprise the Ras superfamily and are involved in essential cell processes such as cell differentiation and proliferation, cytoskeletal organization, vesicle trafficking, and nuclear transport. GTPases are active when bound to GTP and inactive when bound to GDP, allowing their activity to be regulated by GEFs and th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB35
Ras-related protein Rab-35 is a protein that in humans is encoded by the ''RAB35'' gene. This GTPase participates in the traffic of recycling endosomes toward the plasma membrane The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extr ..., References Further reading * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Danish People
Danes (, ), or Danish people, are an ethnic group and nationality native to Denmark and a modern nation identified with the country of Denmark. This connection may be ancestral, legal, historical, or cultural. History Early history Denmark has been inhabited by various Germanic peoples since ancient times, including the Angles (tribe), Angles, Cimbri, Jutes, Herules, Teutones and others. A 2025 study in ''Nature'' found genetic evidence of an influx of central European population after about 500 ce into the region later ruled by the Danes. Viking Age The first mention of Danes within Denmark is on the Jelling stones#Runestone of Harald Bluetooth, Jelling Rune Stone, which mentions the conversion of the Danes to Christianity by Harald Bluetooth in the 10th century. Between and the early 980s, Bluetooth established a kingdom in the lands of the Danes, stretching from Jutland to Scania. Around the same time, he received a visit from a German missionary who, by surviving an t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Klaus Bønnelykke
Klaus is a German, Dutch and Scandinavian given name and surname. It originated as a short form of Nikolaus, a German form of the Greek given name Nicholas. Notable persons whose family name is Klaus * Billy Klaus (1928–2006), American baseball player *Chris Klaus (born 1973), American entrepreneur *Felix Klaus (born 1992), German football player, son of Fred Klaus * Frank Klaus (1887–1948), German-American boxer, 1913 Middleweight Champion * Fred Klaus (born 1967), German football player and manager, father of Felix Klaus *Josef Klaus (1910–2001), Chancellor of Austria 1966–1970 *Karl Ernst Claus (1796–1864), Russian chemist *Václav Klaus (born 1941), Czech politician, former President of the Czech Republic * Walter K. Klaus (1912–2012), American politician and farmer Notable persons whose given name is Klaus * Brother Klaus, Swiss patron saint *Klaus Augenthaler (born 1957), German football player and manager *Klaus Badelt (born 1967), German composer *Klaus B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Bisgaard
Hans may refer to: __NOTOC__ People * Hans (name), a masculine given name * Hans Raj Hans, Indian singer and politician ** Navraj Hans, Indian singer, actor, entrepreneur, cricket player and performer, son of Hans Raj Hans ** Yuvraj Hans, Punjabi actor and singer, son of Hans Raj Hans * Hans clan, a tribal clan in Punjab, Pakistan Places * Hans, Marne, a commune in France * Hans Island, administrated by Greenland and Canada Arts and entertainment * ''Hans'' (film) a 2006 Italian film directed by Louis Nero * Hans (Frozen), the main antagonist of the 2013 Disney animated film ''Frozen'' * ''Hans'' (magazine), an Indian Hindi literary monthly * ''Hans'', a comic book drawn by Grzegorz Rosiński and later by Zbigniew Kasprzak Other uses * Clever Hans, the "wonder horse" * ''The Hans India'', an English language newspaper in India * HANS device, a racing car safety device * Hans, the ISO 15924 code for Simplified Chinese characters See also *Han (other) Han may refer to: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asthma
Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. A sudden worsening of asthma symptoms sometimes called an 'asthma attack' or an 'asthma exacerbation' can occur when allergens, pollen, dust, or other particles, are inhaled into the lungs, causing the bronchioles to constrict and produce mucus, which then restricts oxygen flow to the alveoli. These may occur a few times a day or a few times per week. Depending on the person, asthma symptoms may become worse at night or with exercise. Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta blockers. Diag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
