Steroidal Alkaloids
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Steroidal Alkaloids
Steroidal alkaloids have the basic steroidal skeleton with nitrogen-based functional groups attached to the skeleton. More specifically, they are distinguished by their tetracyclic cyclopentanoperhydrophenanthrene skeleton that marks their close relationship with sterols. They fall in two major categories: Solanum alkaloids and Veratrum alkaloids. A Steroidal alkaloid has also been found in ''Chonemorpha fragrans'' (Frangipani vine), 'chonemorphine' was used to treat intestinal infections in Wistar rats. (Chatterjee DK et al (1987) Parasitol Res 74, 1, 30-33). Examples Apocynaceae steroid alkaloids The family of apocynaceae alkaloids can be categorized based on their backbone structure, which may include the 5α-pregnane, Δ5-pregnane, or conanine backbone. Typically, these alkaloids feature an amino group or an oxygen compound at the 3rd carbon atom. An illustrative example is latifolinin, which is derived from the conanine backbone. This distinctive structure is characte ...
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Solanidine
Solanidine is a poisonous steroidal alkaloid chemical Chemical compound, compound that occurs in plants of the family Solanaceae, such as potato and ''Solanum americanum''. The sugar portion of glycoalkaloids hydrolyses in the body, leaving the solanidine portion. Occurrence Solanidine is the hydrolyzed form of several naturally occurring compounds all found in the Solanaceae family, such as glycoalkaloids, α-solanine and α-chaconine.Kuiper-Goodman, T., Nawrot, P.S.Solanine and Chaconine IPCS Inchem Solanidine is not commonly found in nature, but precursors to it are. Glycoalkaloids are one of the toxins present in Solanum dulcamara and can be found in other Solanum plants as well such as potatoes, tomatoes and eggplant. Solanine is also found in all parts of the Solanum family species and is considered part of the plant's natural defenses. Chaconine is found in specifically green tubers and gives them their bitter taste. Solanidine is found naturally occurring in green potatoe ...
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True Toad
A true toad is any member of the family Bufonidae, in the order Anura (frogs and toads). This is the only family of anurans in which all members are known as toads, although some may be called frogs (such as harlequin frogs). The bufonids now comprise more than 35 genera, '' Bufo'' being the best known. History Bufonidae is thought to have originated in South America. Some studies date the origin of the group to after the breakup of Gondwana, about 78–99 million years ago in the Late Cretaceous. In contrast, other studies have dated the origin of the group to the early Paleocene. The bufonids likely radiated out of South America during the Eocene, with the entire radiation occurring during the Eocene to Oligocene, marking an extremely rapid divergence likely facilitated by the Paleogene's changing climatic conditions. Taxonomy The following phylogeny of most genera in the family is based on Portik and Papenfuss, 2015:, Chan ''et al.'', 2016, Chandramouli ''et al.'', 201 ...
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Potato
The potato () is a starchy tuberous vegetable native to the Americas that is consumed as a staple food in many parts of the world. Potatoes are underground stem tubers of the plant ''Solanum tuberosum'', a perennial in the nightshade family Solanaceae. Wild potato species can be found from the southern United States to southern Chile. Genetic studies show that the cultivated potato has a single origin, in the area of present-day southern Peru and extreme northwestern Bolivia. Potatoes were domesticated there about 7,000–10,000 years ago from a species in the '' S. brevicaule'' complex. Many varieties of the potato are cultivated in the Andes region of South America, where the species is indigenous. The Spanish introduced potatoes to Europe in the second half of the 16th century from the Americas. They are a staple food in many parts of the world and an integral part of much of the world's food supply. Following millennia of selective breeding, there are now over 5 ...
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Solanum
''Solanum'' is a large and diverse genus of flowering plants, which include three food crops of high economic importance: the potato, the tomato and the eggplant (aubergine, brinjal). It is the largest genus in the nightshade family Solanaceae, comprising around 1,500 species. It also contains the so-called horse nettles (unrelated to the genus of true nettles, ''Urtica''), as well as numerous plants cultivated for their ornamental flowers and fruit. ''Solanum'' species show a wide range of growth habits, such as annuals and perennials, vines, subshrubs, shrubs, and small trees. Many formerly independent genera like '' Lycopersicon'' (the tomatoes) and '' Cyphomandra'' are now included in ''Solanum'' as subgenera or sections. Thus, the genus today contains roughly 1,500–2,000 species. Name The generic name was first used by Pliny the Elder (AD 23–79) for a plant also known as , most likely ''S. nigrum''. Its derivation is uncertain, possibly stemming from the Latin ...
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Glycoside
In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. These can be activated by enzymatic, enzyme hydrolysis, which causes the sugar part to be broken off, making the chemical available for use. Many such plant glycosides are used as medications. Several species of ''Heliconius'' butterfly are capable of incorporating these plant compounds as a form of chemical defense against predators. In animals and humans, poisons are often bound to sugar molecules as part of their elimination from the body. In formal terms, a glycoside is any molecule in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Glycosides can be linked by an O- (an ''O-glycoside''), N- (a ''glycosylamine''), S-(a ''thioglycoside''), or C- (a ''C-glycoside'') glycosidic bond. Accord ...
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The Science Of Nature
''The Science of Nature'', formerly ''Naturwissenschaften'', is a monthly peer-reviewed scientific journal published by Springer Science+Business Media covering all aspects of the natural sciences relating to questions of biological significance. It was founded in 1913 and intended as a German-language equivalent of the English-language journal ''Nature'', at a time when German was still a dominant language of the natural sciences. The journal is now published in English. History ''Die Naturwissenschaften'' was founded in 1913 by Arnold Berliner and published by Julius Springer Verlag. Berliner intended to create a German equivalent to the English-language journal ''Nature''. The original subtitle ''Wochenschrift für die Fortschritte der Naturwissenschaften, der Medizin und der Technik'' (''Weekly Publication of the Advances in the Natural Sciences, Medicine and Technology'') was later changed to its current ''The Science of Nature''. The journal is published monthly and the ar ...
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Salamandra
''Salamandra'' is a genus of six species of salamanders localized in central and southern Europe, Northern Africa, and western Asia. List of species References External links Salamandraat Fauna Europaea * Salamandraat Animal Diversity Web Salamandra
at the National Center for Biotechnology Information Salamandra, Amphibian genera Taxa named by Josephus Nicolaus Laurenti {{Salamandridae-stub ...
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Samandarin
Samandarin or Samandarine is the main steroidal alkaloid secreted by the fire salamander (''Salamandra salamandra''). The compound is extremely toxic ( LD50 = 70 μg/kg in mice). Poisoning can cause convulsions, respiratory paralysis, and eventual death. Samandarin is also believed to be the active ingredient in Salamander brandy, a Slovenian traditional medicinal alcoholic drink with purported hallucinogenic and aphrodisiac effects. Samandarine family Samandarin belongs to a family of toxic compounds called samandarines. Samandarines are biologically active, lipid-soluble steroidal alkaloids. They all contain a similar 7-6-6-5 fused ring system. Nine structures in this family have been characterized. Samandarines are exclusively produced and secreted by the fire salamander through their parotoid glands (20 mg/gland). Samandarin is the main component of these glandular secretions, although the precise ratio of the alkaloids can vary from species to species and ind ...
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Salamander Alkaloids
Salamanders are a group of amphibians typically characterized by their lizard-like appearance, with slender bodies, blunt snouts, short limbs projecting at right angles to the body, and the presence of a tail in both larvae and adults. All ten extant salamander families are grouped together under the order Urodela, the sole surviving order from the group Caudata. ''Urodela'' is a scientific Latin term based on the Ancient Greek : ourà dēlē "conspicuous tail". ''Caudata'' is the Latin for "tailed ones", from : "tail". Salamander diversity is highest in eastern North America, especially in the Appalachian Mountains; most species are found in the Holarctic realm, with some species present in the Neotropical realm. Salamanders never have more than four toes on their front legs and five on their rear legs, but some species have fewer digits and others lack hind limbs. Their permeable skin usually makes them reliant on habitats in or near water or other cool, damp places. Some ...
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