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Forensic Statistics
Forensic statistics is the application of probability models and statistical techniques to scientific evidence, such as DNA evidence, and the law. In contrast to "everyday" statistics, to not engender bias or unduly draw conclusions, forensic statisticians report likelihoods as likelihood ratios (LR). This ratio of probabilities is then used by juries or judges to draw inferences or conclusions and decide legal matters. Jurors and judges rely on the strength of a DNA match, given by statistics, to make conclusions and determine guilt or innocence in legal matters. In forensic science, the DNA evidence received for DNA profiling often contains a mixture of more than one person's DNA. DNA profiles are generated using a set procedure, however, the interpretation of a DNA profile becomes more complicated when the sample contains a mixture of DNA. Regardless of the number of contributors to the forensic sample, statistics and probabilities must be used to provide weight to the evidence ...
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Statistical Model
A statistical model is a mathematical model that embodies a set of statistical assumptions concerning the generation of Sample (statistics), sample data (and similar data from a larger Statistical population, population). A statistical model represents, often in considerably idealized form, the Data generating process, data-generating process. When referring specifically to probability, probabilities, the corresponding term is probabilistic model. All Statistical hypothesis testing, statistical hypothesis tests and all Estimator, statistical estimators are derived via statistical models. More generally, statistical models are part of the foundation of statistical inference. A statistical model is usually specified as a mathematical relationship between one or more random variables and other non-random variables. As such, a statistical model is "a formal representation of a theory" (Herman J. Adèr, Herman Adèr quoting Kenneth A. Bollen, Kenneth Bollen). Introduction Informally, a ...
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Statistics
Statistics (from German language, German: ', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of statistical survey, surveys and experimental design, experiments. When census data (comprising every member of the target population) cannot be collected, statisticians collect data by developing specific experiment designs and survey sample (statistics), samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample ...
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Scientific Evidence
Scientific evidence is evidence that serves to either support or counter a scientific theory or hypothesis, although scientists also use evidence in other ways, such as when applying theories to practical problems. "Discussions about empirical evidence have tended to focus on epistemological questions regarding its role in theory testing ... even though empirical evidence also plays important and philosophically interesting roles in other areas including scientific discovery, the development of experimental tools and techniques, and the application of scientific theories to practical problems." Such evidence is expected to be empirical evidence and interpretable in accordance with the scientific method. Standards for scientific evidence vary according to the field of inquiry, but the strength of scientific evidence is generally based on the results of Statistics, statistical analysis and the strength of scientific controls. Principles of inference A person's assumptions or ...
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DNA Profiling
DNA profiling (also called DNA fingerprinting and genetic fingerprinting) is the process of determining an individual's deoxyribonucleic acid (DNA) characteristics. DNA analysis intended to identify a species, rather than an individual, is called DNA barcoding. DNA profiling is a forensic technique in criminal investigations, comparing criminal suspects' profiles to DNA evidence so as to assess the likelihood of their involvement in the crime. It is also used in paternity testing, to establish immigration eligibility, and in genealogical and medical research. DNA profiling has also been used in the study of animal and plant populations in the fields of zoology, botany, and agriculture. Background Starting in the mid 1970s, scientific advances allowed the use of DNA as a material for the identification of an individual. The first patent covering the direct use of DNA variation for forensicsUS5593832A was filed by Jeffrey Glassberg in 1983, based upon work he had done while ...
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Likelihood Function
A likelihood function (often simply called the likelihood) measures how well a statistical model explains observed data by calculating the probability of seeing that data under different parameter values of the model. It is constructed from the joint probability distribution of the random variable that (presumably) generated the observations. When evaluated on the actual data points, it becomes a function solely of the model parameters. In maximum likelihood estimation, the argument that maximizes the likelihood function serves as a point estimate for the unknown parameter, while the Fisher information (often approximated by the likelihood's Hessian matrix at the maximum) gives an indication of the estimate's precision. In contrast, in Bayesian statistics, the estimate of interest is the ''converse'' of the likelihood, the so-called posterior probability of the parameter given the observed data, which is calculated via Bayes' rule. Definition The likelihood function, ...
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Jury
A jury is a sworn body of people (jurors) convened to hear evidence, make Question of fact, findings of fact, and render an impartiality, impartial verdict officially submitted to them by a court, or to set a sentence (law), penalty or Judgment (law), judgment. Most trial juries are "petit juries", and consist of up to 15 people. A larger jury known as a grand jury has been used to investigate potential crimes and render indictments against suspects, and consists of between 16 and 23 jurors. The jury system developed in England during the Middle Ages and is a hallmark of the English common law system. Juries are commonly used in countries whose legal systems derive from the British Empire, such as the United Kingdom, the United States, Canada, Australia, and Republic of Ireland, Ireland. They are not used in most other countries, whose legal systems are based upon European Civil law (legal system), civil law or Islamic sharia, sharia law, although their use has been spreading. ...
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Judge
A judge is a person who wiktionary:preside, presides over court proceedings, either alone or as a part of a judicial panel. In an adversarial system, the judge hears all the witnesses and any other Evidence (law), evidence presented by the barristers or solicitors of the case, assesses the credibility and arguments of the parties, and then issues a Court order, ruling in the Case law, case based on their Judicial interpretation, interpretation of the law and their own personal judgment. A judge is expected to conduct the trial impartially and, typically, in an in open court, open court. The powers, functions, method of appointment, discipline, and training of judges vary widely across different jurisdictions. In some jurisdictions, the judge's powers may be shared with a jury. In inquisitorial systems of criminal investigation, a judge might also be an examining magistrate. The presiding judge ensures that all court proceedings are lawful and orderly. Powers and functions The ult ...
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Random Match Possibility
In common usage, randomness is the apparent or actual lack of definite pattern or predictability in information. A random sequence of events, symbols or steps often has no order and does not follow an intelligible pattern or combination. Individual random events are, by definition, unpredictable, but if there is a known probability distribution, the frequency of different outcomes over repeated events (or "trials") is predictable.Strictly speaking, the frequency of an outcome will converge almost surely to a predictable value as the number of trials becomes arbitrarily large. Non-convergence or convergence to a different value is possible, but has probability zero. Consistent non-convergence is thus evidence of the lack of a fixed probability distribution, as in many evolutionary processes. For example, when throwing two dice, the outcome of any particular roll is unpredictable, but a sum of 7 will tend to occur twice as often as 4. In this view, randomness is not haphazardne ...
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Genotype Frequencies
Genetic variation in populations can be analyzed and quantified by the frequency of alleles. Two fundamental calculations are central to population genetics: allele frequencies and genotype frequencies. Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 < ''f'' < 1) of genotypes in a population. Although allele and genotype frequencies are related, it is important to clearly distinguish them. Genotype frequency may also be used in the future (for "genomic profiling") to predict someone's having a disease or even a birth defect. It can also be used to determine ethnic diversity. Genotype frequencies may be represented by a .


Numerica ...
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Product Rule
In calculus, the product rule (or Leibniz rule or Leibniz product rule) is a formula used to find the derivatives of products of two or more functions. For two functions, it may be stated in Lagrange's notation as (u \cdot v)' = u ' \cdot v + u \cdot v' or in Leibniz's notation as \frac (u\cdot v) = \frac \cdot v + u \cdot \frac. The rule may be extended or generalized to products of three or more functions, to a rule for higher-order derivatives of a product, and to other contexts. Discovery Discovery of this rule is credited to Gottfried Leibniz, who demonstrated it using "infinitesimals" (a precursor to the modern differential). (However, J. M. Child, a translator of Leibniz's papers, argues that it is due to Isaac Barrow.) Here is Leibniz's argument: Let ''u'' and ''v'' be functions. Then ''d(uv)'' is the same thing as the difference between two successive ''uvs; let one of these be ''uv'', and the other ''u+du'' times ''v+dv''; then: \begin d(u\cdot v) & = (u + d ...
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Electropherogram
An electropherogram (also called electrophoretogram, sequencing chromatogram, EPG, and e-gram) is a record or chart produced when electrophoresis is used in an analytical technique, primarily in the fields of forensic biology, molecular biology, and biochemistry. The method plots data points that represent a specific time and fluorescence intensity at various wavelengths of light to represent a DNA profile.. In the field of genetics, an electropherogram is a plot of DNA fragment sizes, typically used for genotyping such as DNA sequencing. The data is plotted with time, shown via base pairs (bps), on the x-axis and fluorescence intensity on the y-axis. Such plots are often achieved using an instrument such as an automated DNA sequencer paired with capillary electrophoresis (CE). Such electropherograms may be used to determine DNA sequence genotypes, or genotypes that are based on the length of specific DNA fragments or number of short tandem repeats (STR) at a specific locus b ...
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