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Convection Enhanced Delivery
Convection-enhanced delivery (CED) is method of drug delivery in which the drug is delivered into the brain using bulk flow rather than conventional diffusion. This is done by utilizing catheters inserted into the target region of the brain and utilizing pressure to deliver the therapeutic to a target region. CED has been used to delivery drugs to the central nervous system (CNS) for diseases such as cancer, epilepsy, and Parkinson's disease. CED has been used to deliver drugs to the CNS for its ability to bypass the blood–brain barrier (BBB) and target specific regions for targeted treatment, but current techniques using CED have failed to progress past clinical trials due to a variety of physical limitations associated with CED itself. Background The blood brain barrier (BBB) has historically proved to be a very difficult obstacle to overcome when aiming to deliver a drug to the brain. In order to overcome the difficulties in delivering therapeutic levels of drug past the BBB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bulk Flow
In the life sciences, mass flow, also known as mass transfer and bulk flow, is the movement of fluids down a pressure or temperature gradient.Moyes & Schulte (2008). Principles of Animal Physiology. Pearson Benjamin Cummings. San Francisco, California As such, mass flow is a subject of study in both fluid dynamics and biology. Examples of mass flow include blood circulation and transport of water in vascular plant tissues. Mass flow is not to be confused with diffusion which depends on concentration gradients within a medium rather than pressure gradients of the medium itself. Plant biology In general, bulk flow in plant biology typically refers to the movement of water from the soil up through the plant to the leaf tissue through xylem, but can also be applied to the transport of larger solutes (e.g. sucrose) through the phloem. Xylem According to xylem#Cohesion-tension theory, cohesion-tension theory, water transport in xylem relies upon the cohesion of water molecules to eac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
