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Conus Parius
''Conus parius'', common name the Parian cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies. Like all species within the genus ''Conus'', these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully or not at all. Description The size of the shell varies between 25 mm and 46 mm. The color of the shell is white to pale yellowish, often longitudinally indistinctly marked with deeper coloring. The spire is striate. The lower part of the body whorl is distantly sulcate. Conantokin-Pr1, -Pr2 and -Pr3 are toxins derived from the venom of Conus parius. These small neurotoxic peptides have been found to act as NMDA antagonists ''in vitro'', and stimulate production of the transcription factor CREB in the brain. Distribution This marine species occurs off the Philippines and Indonesia; off Papua New Guinea, the Solomon Islands and Vanuatu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastropod Shell
The gastropod shell is part of the body of a Gastropoda, gastropod or snail, a kind of mollusc. The shell is an exoskeleton, which protects from predators, mechanical damage, and dehydration, but also serves for muscle attachment and calcium storage. Some gastropods appear shell-less (slugs) but may have a remnant within the mantle, or in some cases the shell is reduced such that the body cannot be retracted within it (semi-slug). Some snails also possess an operculum that seals the opening of the shell, known as the Aperture (mollusc), aperture, which provides further protection. The study of mollusc shells is known as conchology. The biological study of gastropods, and other molluscs in general, is malacology. Shell morphology terms vary by species group. Shell layers The gastropod shell has three major layers secreted by the Mantle (mollusc), mantle. The calcareous central layer, tracum, is typically made of calcium carbonate precipitated into an organic matrix known as c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conantokin
Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus ''Conus''. Conantokins act as potent and specific antagonists of the N-methyl-D-aspartate receptor (NMDAR). They are the only naturally-derived peptides to do so. The subtypes of conantokins exhibit a surprising variability of selectivity across the NMDAR subunits, and are therefore uniquely useful in developing subunit-specific pharmacological probes. Chemically, conantokins are unique in that they possess a number (generally 4 or 5) of gamma-carboxyglutamyl (Gla) residues, generated by the post-translational modification of glutamyl (Glu) residues. These Gla residues induce a conformational change from a 3 10 helix to an alpha helix on binding to Calcium. In the broader scheme of genetic conotoxin classification, Conanotokins are also known as "Conotoxin Superfamily B." The word "conantokin" is derived from the Filipino word ''antokin'', meaning sleepy. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solomon Islands
Solomon Islands is an island country consisting of six major islands and over 900 smaller islands in Oceania, to the east of Papua New Guinea and north-west of Vanuatu. It has a land area of , and a population of approx. 700,000. Its capital, Honiara, is located on the largest island, Guadalcanal. The country takes its name from the wider area of the Solomon Islands (archipelago), which is a collection of Melanesian islands that also includes the Autonomous Region of Bougainville (currently a part of Papua New Guinea), but excludes the Santa Cruz Islands. The islands have been settled since at least some time between 30,000 and 28,800 BCE, with later waves of migrants, notably the Lapita people, mixing and producing the modern indigenous Solomon Islanders population. In 1568, the Spanish navigator Álvaro de Mendaña was the first European to visit them. Though not named by Mendaña, it is believed that the islands were called ''"the Solomons"'' by those who later r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Papua New Guinea
Papua New Guinea (abbreviated PNG; , ; tpi, Papua Niugini; ho, Papua Niu Gini), officially the Independent State of Papua New Guinea ( tpi, Independen Stet bilong Papua Niugini; ho, Independen Stet bilong Papua Niu Gini), is a country in Oceania that comprises the eastern half of the island of New Guinea and its offshore islands in Melanesia (a region of the southwestern Pacific Ocean north of Australia). Its capital, located along its southeastern coast, is Port Moresby. The country is the world's third largest island country, with an area of . At the national level, after being ruled by three external powers since 1884, including nearly 60 years of Australian administration starting during World War I, Papua New Guinea established its sovereignty in 1975. It became an independent Commonwealth realm in 1975 with Elizabeth II as its queen. It also became a member of the Commonwealth of Nations in its own right. There are 839 known languages of Papua New Guinea, on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indonesia
Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania between the Indian and Pacific oceans. It consists of over 17,000 islands, including Sumatra, Java, Sulawesi, and parts of Borneo and New Guinea. Indonesia is the world's largest archipelagic state and the 14th-largest country by area, at . With over 275 million people, Indonesia is the world's fourth-most populous country and the most populous Muslim-majority country. Java, the world's most populous island, is home to more than half of the country's population. Indonesia is a presidential republic with an elected legislature. It has 38 provinces, of which nine have special status. The country's capital, Jakarta, is the world's second-most populous urban area. Indonesia shares land borders with Papua New Guinea, East Timor, and the East Malaysia, eastern part of Malaysia, as well as maritime borders with Singapore, Vietnam, Thailand, the Philippines, Australia, Palau, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippines
The Philippines (; fil, Pilipinas, links=no), officially the Republic of the Philippines ( fil, Republika ng Pilipinas, links=no), * bik, Republika kan Filipinas * ceb, Republika sa Pilipinas * cbk, República de Filipinas * hil, Republika sang Filipinas * ibg, Republika nat Filipinas * ilo, Republika ti Filipinas * ivv, Republika nu Filipinas * pam, Republika ning Filipinas * krj, Republika kang Pilipinas * mdh, Republika nu Pilipinas * mrw, Republika a Pilipinas * pag, Republika na Filipinas * xsb, Republika nin Pilipinas * sgd, Republika nan Pilipinas * tgl, Republika ng Pilipinas * tsg, Republika sin Pilipinas * war, Republika han Pilipinas * yka, Republika si Pilipinas In the recognized optional languages of the Philippines: * es, República de las Filipinas * ar, جمهورية الفلبين, Jumhūriyyat al-Filibbīn is an archipelagic state, archipelagic country in Southeast Asia. It is situated in the western Pacific Ocean and consists of aro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: ''c-fos'', BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock ( PER1, PER2). CREB is closely related in structure and function to CREM ( cAMP response element modulator) and ATF-1 ( activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory. CREB downr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NMDA Antagonist
NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Several synthetic opioids function additionally as NMDAR-antagonists, such as pethidine, levorphanol, methadone, dextropropoxyphene, tramadol and ketobemidone. Some NMDA receptor antagonists, such as ketamine, dextromethorphan (DXM), phencyclidine (PCP), methoxetamine (MXE), and nitrous oxide (N2O), are sometimes used as recreational drugs, for their dissociative, hallucinogenic, and euphoriant properties. When used recreationally, they are classified as dissociative drugs. Uses and effects NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. Ketamine is a favored anesthetic for emergency patients with unknown med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxic
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. This can eventually disrupt or even kill neurons, which are cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from organ transplants, radiation treatment, certain drug therapies, recreational drug use, and exposure to heavy metals, bites from certain species of venomous snakes, pesticides, certain industrial cleaning solvents, fuels and certain naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness, loss of memory, vision, and/o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Body Whorl
The body whorl is part of the morphology of the shell in those gastropod mollusks that possess a coiled shell. The term is also sometimes used in a similar way to describe the shell of a cephalopod mollusk. In gastropods In gastropods, the body whorl, or last whorl, is the most recently formed and largest whorl (or revolution) of a spiral or helical shell, terminating in the aperture. It is called the "body whorl" because most of the body of the soft parts of the animal fits into this whorl. The proportional size of the body whorl in gastropod shells differs greatly according to the actual shell morphology. For shells in which the rate of whorl expansion of each revolution around the axis is very high, the aperture and the body whorl are large, and the shell tends to be low spired. The shell of the abalone is a good example of this kind of shell. The opposite tendency can sometimes create a high spire with very little whorl increase per revolution. In these instances ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lovell Augustus Reeve
Lovell Augustus Reeve (19 April 1814 – 18 November 1865) was an English conchologist and publisher. Life Born at Ludgate Hill, London, on 19 April 1814, he was a son of Thomas Reeve, draper and mercer, by his wife Fanny Lovell. After attending school at Stockwell, he was apprenticed at the age of 13 to Mr. Graham, a local grocer. The chance of purchase of some shells led to a lifelong interest in conchology. In 1833 he attended the meeting of the British Association for the Advancement of Science at Cambridge. At the end of his apprenticeship Reeve paid a visit to Paris, where he read a paper on the classification of Mollusca before the Academy of Sciences. On his return to London, he set to work on his first book, ''Conchologia Systematica'' (2 vols. London, 1841–2). From 1842, he traded as a natural history dealer. Using profits made by the sale of Dutch Governor-General of the Moluccas Van Ryder's collection from the Moluccas, which he purchased at Rotterdam, and with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
