''Conus parius'', common name the Parian cone, is a species of sea snail, a marine gastropod

mollusk Mollusca is the second-largest phylum of invertebrate animals after the Arthropoda, the members of which are known as molluscs or mollusks (). Around 85,000 extant species of molluscs are recognized. The number of fossil species is es ...

in the

family Family (from la, familia) is a group of people related either by consanguinity (by recognized birth) or affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its members and of society. Idea ...

Conidae Conidae, with the current common name of " cone snails", is a taxonomic family (previously subfamily) of predatory sea snails, marine gastropod molluscs in the superfamily Conoidea. The 2014 classification of the superfamily Conoidea, group ...

, the

cone snails A cone is a three-dimensional geometric shape that tapers smoothly from a flat base (frequently, though not necessarily, circular) to a point called the apex or vertex. A cone is formed by a set of line segments, half-lines, or lines ...

and their allies. Like all species within the genus ''Conus'', these snails are

predatory Predation is a biological interaction where one organism, the predator, kills and eats another organism, its prey. It is one of a family of common feeding behaviours that includes parasitism and micropredation (which usually do not kill t ...

and

venomous Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved ''venom apparatus'', such as fangs or a ...

. They are capable of "stinging" humans, therefore live ones should be handled carefully or not at all.

Description

The size of the shell varies between 25 mm and 46 mm. The color of the shell is white to pale yellowish, often longitudinally indistinctly marked with deeper coloring. The

spire A spire is a tall, slender, pointed structure on top of a roof of a building or tower, especially at the summit of church steeples. A spire may have a square, circular, or polygonal plan, with a roughly conical or pyramidal shape. Spires are ...

is striate. The lower part of the body whorl is distantly sulcate.

Conantokin Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus ''Conus''. Conantokins act as potent and specific antagonists of the N-methyl-D-aspartate receptor (NMDAR). They are the onl ...

-Pr1, -Pr2 and -Pr3 are toxins derived from the venom of Conus parius. These small

neurotoxic Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specifical ...

peptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. ...

s have been found to act as

NMDA antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induc ...

s ''in vitro'', and stimulate production of the transcription factor

CREB CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first de ...

in the brain.

Distribution

This marine species occurs off the

Philippines The Philippines (; fil, Pilipinas, links=no), officially the Republic of the Philippines ( fil, Republika ng Pilipinas, links=no), * bik, Republika kan Filipinas * ceb, Republika sa Pilipinas * cbk, República de Filipinas * hil, Republ ...

and

Indonesia Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania between the Indian and Pacific oceans. It consists of over 17,000 islands, including Sumatra, Java, Sulawesi, and parts of Borneo and New Guine ...

; off

Papua New Guinea Papua New Guinea (abbreviated PNG; , ; tpi, Papua Niugini; ho, Papua Niu Gini), officially the Independent State of Papua New Guinea ( tpi, Independen Stet bilong Papua Niugini; ho, Independen Stet bilong Papua Niu Gini), is a country i ...

, the

Solomon Islands Solomon Islands is an island country consisting of six major islands and over 900 smaller islands in Oceania, to the east of Papua New Guinea and north-west of Vanuatu. It has a land area of , and a population of approx. 700,000. Its ca ...

and

Vanuatu Vanuatu ( or ; ), officially the Republic of Vanuatu (french: link=no, République de Vanuatu; bi, Ripablik blong Vanuatu), is an island country located in the South Pacific Ocean. The archipelago, which is of volcanic origin, is east of no ...

References

J.B. Lamarck, ''Histoire naturelle des animaux sans vertèbres'' t. 11 Paris,Verdière,1845
* Tucker J.K. & Tenorio M.J. (2009) ''Systematic classification of Recent and fossil conoidean gastropods.'' Hackenheim: Conchbooks. 296 pp.
Puillandre N., Duda T.F., Meyer C., Olivera B.M. & Bouchet P. (2015). ''One, four or 100 genera? A new classification of the cone snails.'' Journal of Molluscan Studies. 81: 1–23

External links

The ''Conus'' Biodiversity website

Cone Shells - Knights of the Sea
* {{DEFAULTSORT:Conus Parius parius Gastropods described in 1844