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Class B GPCR
Secretin receptor family (class B G-protein coupled receptors, GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family is different from adhesion G protein-coupled receptors. The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin receptor, secretin, calcitonin receptor, calcitonin and parathyroid hormone receptor, parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the Phospholipase C#Effects, phosphatidyl-inositol-calcium pathway. The receptors in this family have seven Transmembrane domain, transmembrane Alpha helix, helices,; ; like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic Seven transmembrane protein, 7TM signature. The secretin-receptor family GPCRs exist in many animal species. D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G-protein Coupled Receptors
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. They are coupled with G proteins. They pass through the cell membrane seven times in the form of six loops (three extracellular loops interacting with ligand molecules, three intracellular loops interacting with G proteins, an N-terminal extracellular region and a C-terminal intracellular region) of amino acid residues, which is why they are sometimes referred to as seven-transmembrane receptors. Text was copied from this source, which is available under Attribution 2.5 Generic (CC BY 2.5) licence/ref> Ligands can bind either to the extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
