Ciguatoxin 1
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Ciguatoxin 1
Ciguatoxin 1 or CTX-1 is a toxic chemical compound, the most common and potent type in the group of ciguatoxins. It is a large molecule consisting of polycyclic polyethers that can be found in certain types of fish in the Pacific Ocean. The compound is produced by Dinoflagellates ''Gambierdiscus toxicus'' and is passed on through the food chain by fish. The compound has no effect in fish but is toxic to humans.   History Before ciguatoxin was discovered and identified, its presence in the food chain was hypothesised by Randall et al, who assumed that the toxin enters the food chain via herbivorous fish that feed on toxic microalgae and then gets passed on to humans directly or by passing through other carnivorous fish. This hypothesis was proven by Helfrich and Banner, who also showed that the toxin has no effect on fish, both herbivorous and carnivorous. Ciguatoxin-1 was first discovered in 1967 by Scheuer et al when studying ciguatera fish responsible for food poisoning. ...
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Ciguatoxin
image:ciguatoxin.svg, 300px, class=skin-invert-image, Chemical structure of the ciguatoxin CTX1B Ciguatoxins are a class of toxic Polycyclic compound, polycyclic polyethers found in fish that cause ciguatera. There are several different chemicals in this class. "CTX" is often used as an abbreviation. * Ciguatoxin 1 - * Ciguatoxin 2 - * Ciguatoxin 3 - * Ciguatoxin 4B (Gambiertoxin 4b) - Toxic effect on humans Ciguatoxins do not seem to harm the fish that carry them, but they are poisonous to humans. They cannot be smelled or tasted and cannot be destroyed by cooking. Rapid testing for this toxin in food is not standard. Some ciguatoxins lower the threshold for opening excitatory voltage-gated sodium channels in the nervous system. Opening a sodium channel causes depolarization, which could sequentially cause paralysis, heart arrhythmia, and changing the senses of heat and cold. Such poisoning from ciguatoxins is known as ciguatera. Ciguatoxins are lipophilic, able to cros ...
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Subtropics
The subtropical zones or subtropics are geographical and climate zones immediately to the north and south of the tropics. Geographically part of the temperate zones of both hemispheres, they cover the middle latitudes from to approximately 35° to 40° north and south. The horse latitudes lie within this range. Subtropical climates are often characterized by hot summers and mild winters with infrequent frost. Most subtropical climates fall into two basic types: humid subtropical (Köppen climate classification: Cfa/Cwa), where rainfall is often concentrated in the warmest months, for example Southeast China and the Southeastern United States, and dry summer or Mediterranean climate (Köppen climate classification: Csa/Csb), where seasonal rainfall is concentrated in the cooler months, such as the Mediterranean Basin or Southern California. Subtropical climates can also occur at high elevations within the tropics, such as in the southern end of the Mexican Plateau an ...
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Bradycardia
Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM). While bradycardia can result from various pathological processes, it is commonly a physiological response to cardiovascular conditioning or due to asymptomatic type 1 atrioventricular block. Resting heart rates of less than 50 BPM are often normal during sleep in young and healthy adults and athletes. In large population studies of adults without underlying heart disease, resting heart rates of 45–50 BPM appear to be the lower limits of normal, dependent on age and sex. Bradycardia is most likely to be discovered in the elderly, as age and underlying cardiac disease progression contribute to its development. Bradycardia may be associated with symptoms of fatigue, dyspnea, dizziness, confusion, and syncope due to reduced blood flow to the brain. The types of symptoms often depend on the etiology of the slow heart rate, classified by the anatomical location of a dysfunctio ...
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Hypotension
Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and is indicated by two numbers, the systolic blood pressure (the top number) and the diastolic blood pressure (the bottom number), which are the maximum and minimum blood pressures within the cardiac cycle, respectively. A systolic blood pressure of less than 90 millimeters of mercury (mmHg) or diastolic of less than 60 mmHg is generally considered to be hypotension. Different numbers apply to children. However, in practice, blood pressure is considered too low only if noticeable symptoms are present. Symptoms may include dizziness, lightheadedness, confusion, feeling tired, weakness, headache, blurred vision, nausea, neck or back pain, an irregular heartbeat or feeling that the heart is skipping beats or fluttering, sweating, an ...
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Neuropsychology
Neuropsychology is a branch of psychology concerned with how a person's cognition and behavior are related to the brain and the rest of the nervous system. Professionals in this branch of psychology focus on how injuries or illnesses of the brain affect cognitive and behavioral functions. It is both an experimental and clinical field of patient-focused psychology. Thus aiming to understand how behavior and cognition are influenced by brain function. It is also concerned with the diagnosis and treatment of behavioral and cognitive effects of neurological disorders. Whereas classical neurology focuses on the pathology of the nervous system and classical psychology is largely divorced from it, neuropsychology seeks to discover how the brain correlates with the mind through the study of neurological patients. It thus shares concepts and concerns with neuropsychiatry and with behavioral neurology in general. The term ''neuropsychology'' has been applied to lesion studies in huma ...
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Neurology
Neurology (from , "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine) , medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous system, which comprises the Human brain, brain, the spinal cord and the peripheral nervous system , peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system, using various techniques of neurotherapy. IEEE Brain (2019). "Neurotherapy: Treating Disorders by Retraining the Brain". ''The Future Neural Therapeutics White Paper''. Retrieved 23.01.2025 from: https://brain.ieee.org/topics/neurotherapy-treating-disorders-by-retraining-the-brain/#:~:text=Neurotherapy%20trains%20a%20patient's%20brain,wave%20activity%20through%20positive%20reinforcement International Neuromodulation Society, Retrieved 23 January 2025 from: https://www.neuromodulation.com/ Val Danilov I (2023). "The O ...
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Heart
The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrients to the tissue, while carrying metabolic waste such as carbon dioxide to the lungs. In humans, the heart is approximately the size of a closed fist and is located between the lungs, in the middle compartment of the thorax, chest, called the mediastinum. In humans, the heart is divided into four chambers: upper left and right Atrium (heart), atria and lower left and right Ventricle (heart), ventricles. Commonly, the right atrium and ventricle are referred together as the right heart and their left counterparts as the left heart. In a healthy heart, blood flows one way through the heart due to heart valves, which prevent cardiac regurgitation, backflow. The heart is enclosed in a protective sac, the pericardium, which also contains a sma ...
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Gastrointestinal Tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the Digestion, digestive system that leads from the mouth to the anus. The tract is the largest of the body's systems, after the cardiovascular system. The GI tract contains all the major organ (biology), organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digestion, digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. ''Gastrointestinal'' is an adjective meaning of or pertaining to the stomach and intestines. Nephrozoa, Most animals have a "through-gut" or complete digestive tract. Exceptions are more primitive ones: sponges have small pores (ostium (sponges), ostia) throughout their body for digestion and a larger dorsal pore (osculum) for excretion, comb jellies have both a ventral mouth and dorsal anal pores, while cnidarians and acoels have ...
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Ciguatera Fish Poisoning
Ciguatera fish poisoning (CFP), also known as ciguatera, is a foodborne illness caused by eating tropical reef fish contaminated with ciguatoxins. Such individual fish are said to be ciguatoxic. Symptoms may include diarrhea, vomiting, numbness, itchiness, dysesthesia, sensitivity to hot and cold, dizziness, and weakness with lethargy. The onset of symptoms varies with the amount of toxin absorbed. If a large quantity of toxins are consumed symptoms may appear within half an hour. If a low amount of toxins are consumed symptoms may take a few days to appear. Diarrhea may last up to four days. Symptoms may last a few weeks to a few months. Heart problems such as slow heart rate and low blood pressure may occur. The specific toxins involved are the ciguatoxins and maitotoxin. They are originally made by a small marine organism, ''Gambierdiscus toxicus'', that grows on and around coral reefs in tropical and subtropical waters. These are eaten by herbivorous fish which in turn are e ...
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Grouper
Groupers are a diverse group of marine ray-finned fish in the family Epinephelidae, in the order Perciformes. Groupers were long considered a subfamily of the seabasses in Serranidae, but are now treated as distinct. Not all members of this family are called "groupers". The common name "grouper" is usually given to fish in one of two large genera: ''Epinephelus'' and '' Mycteroperca''. In addition, the species classified in the small genera ''Anyperidon'', ''Cromileptes'', ''Dermatolepis'', ''Graciela'', ''Saloptia'', and ''Triso'' are also called "groupers". Fish in the genus '' Plectropomus'' are referred to as "coral groupers". These genera are all classified in the subfamily Epiphelinae. However, some of the hamlets (genus ''Alphestes''), the hinds (genus ''Cephalopholis''), the lyretails (genus ''Variola''), and some other small genera (''Gonioplectrus'', ''Niphon'', ''Paranthias'') are also in this subfamily, and occasional species in other serranid genera have common na ...
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Spanish Mackerel
Scomberomorini is a tribe of ray-finned, saltwater, bony fishes that is commonly known as Spanish mackerels, seerfishes, or seer fish. This tribe is a subset of the mackerel family (Scombridae), which it shares with four sister tribes, the tunas, mackerels, bonitos, and butterfly kingfish. Scomberomorini comprises 21 species across three genera. They are pelagic fish, fast swimmers and predatory in nature, that fight vigorously when caught. They are mainly caught using hooks and lines. Taxonomy The following cladogram shows the most likely evolutionary relationships between the Spanish mackerels and the tunas, mackerels, bonitos, and butterfly kingfish. This tribe comprises 21 species in three genera: * '' Acanthocybium'' (Gill, 1862) ** '' A. solandri'' ( Cuvier, 1832), wahoo * '' Grammatorcynus'' (Gill, 1862) ** '' G. bicarinatus'' ( Quoy & Gaimard, 1825), shark mackerel ** '' G. bilineatus'' ( Rüppell, 1836), double-lined mackerel * '' Scomberomorus'' ( Lac ...
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Lutjanidae
Lutjanidae or snappers are a family of perciform fishes, mainly marine but with some members inhabiting estuaries and, in some cases, fresh water (e.g., '' Lutjanus goldiei''). The family includes about 113 species. Most species are used for food and many are of high economic importance. Many species around the world are known in local languages as red snapper, including species from different genera (including Lutjanus and Pristipomoides) Snappers inhabit tropical, subtropical, and warm-temperate regions of all oceans. Some snappers grow up to about in length, and one species, the cubera snapper, grows up to in length. Most are active carnivores, feeding on crustaceans or other fishes, though a few are plankton-feeders. They can be kept in aquaria, but commonly grow too fast to be popular aquarium fish. Most species live at depths reaching near coral reefs, but some species are found up to deep. As with other fishes, some snapper species host parasites. A detailed st ...
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