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Center For Infectious Disease Research
The Center for Infectious Disease Research (CIDR) is housed at the Medical College of Wisconsin (MCW) in Milwaukee. The CIDR houses a BSL3 laboratory. As of 2021, its focus is "on understanding the molecular mechanisms of pathogenesis related to infection with all types of microorganisms, viruses, fungi or parasites." History The CIDR was established in 2002 as the Center for Bioterrorism and Infectious Diseases (CBID). The name was changed to its current status in 2010. Over a three-year period in the early 2010s, a total of four notifiable accidents involving dermal punctures. As of 2015, the MCW operated two BSL-3 laboratories both on the main campus in Wauwatosa. In May 2015, it was reported that "MCW's lab is registered with the federal government to work with the Gram-negative bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical College Of Wisconsin
The Medical College of Wisconsin (MCW) is a private medical school, pharmacy school, and graduate school of sciences in Milwaukee, Wisconsin, United States. The school was established in 1893 and is the largest research center in eastern Wisconsin. It is associated with Froedtert Hospital as well as Children's Hospital of Wisconsin and houses the Center for Infectious Disease Research. There are two additional campuses, one in Green Bay, Wisconsin, Green Bay and one in Wausau, Wisconsin, Wausau. MCW is accredited by the Higher Learning Commission (HLC) and the Liaison Committee on Medical Education (LCME). It is the only private medical school in Wisconsin, and one of only two medical schools in Wisconsin, along with the University of Wisconsin School of Medicine and Public Health in Madison, Wisconsin, Madison. History The Medical College originated with the founding of the Wisconsin College of Physicians and Surgeons in 1893 and of Milwaukee Medical College in 1894. In 1906, Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milwaukee
Milwaukee is the List of cities in Wisconsin, most populous city in the U.S. state of Wisconsin. Located on the western shore of Lake Michigan, it is the List of United States cities by population, 31st-most populous city in the United States and the fifth-most populous city in the Midwest with a population of 577,222 at the 2020 United States census, 2020 census. It is the county seat of Milwaukee County, Wisconsin, Milwaukee County. The Milwaukee metropolitan area is the Metropolitan statistical area, 40th-most populous metropolitan area in the U.S. with 1.57 million residents. Founded in the early 19th century and incorporated in 1846, Milwaukee grew rapidly due to its location as a port city. History of Milwaukee, Its history was heavily influenced by German immigrants and it continues to be a Germans in Milwaukee, center for German-American culture, specifically known for Beer in Milwaukee, its brewing industry. The city developed as an industrial powerhouse during the 19t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microorganisms
A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from antiquity, with an early attestation in Jain literature authored in 6th-century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s, Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera, diphtheria, and anthrax. Microorganisms are extremely diverse, representing most unicellular organisms in all three domains of life: two of the three domains, Archaea and Bacteria, only contain microorganisms. The third domain, Eukaryota, includes all multicellular organisms as well as many unicellular protists and protozoans that ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viruses
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 16,000 of the millions of virus species have been described in detail. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent viral particles, or ''virions'', consisting of (i) genetic material, i.e., long molecules of DNA or RNA that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungi
A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and mold (fungus), molds, as well as the more familiar mushrooms. These organisms are classified as one of the kingdom (biology)#Six kingdoms (1998), traditional eukaryotic kingdoms, along with Animalia, Plantae, and either Protista or Protozoa and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of motility, mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parasites
Parasitism is a close relationship between species, where one organism, the parasite, lives (at least some of the time) on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson characterised parasites' way of feeding as "predators that eat prey in units of less than one". Parasites include single-celled protozoans such as the agents of malaria, sleeping sickness, and amoebic dysentery; animals such as hookworms, lice, mosquitoes, and vampire bats; fungi such as honey fungus and the agents of ringworm; and plants such as mistletoe, dodder, and the broomrapes. There are six major parasitic strategies of exploitation of animal hosts, namely parasitic castration, directly transmitted parasitism (by contact), trophicallytransmitted parasitism (by being eaten), vector-transmitted parasitism, parasitoidism, and micropredation. One major axis of classification concerns invasiveness: an endo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wauwatosa
Wauwatosa ( ; colloquially Tosa) is a city in Milwaukee County, Wisconsin, United States. The population was 48,387 at the 2020 census. Wauwatosa is a suburb located immediately west of Milwaukee and is part of the Milwaukee metropolitan area. It is named after the Potawatomi Chief Wauwataesie and the Potawatomi word for firefly. History The lush Menomonee Valley of the Wauwatosa area provided a key overland gateway between the rich glacial farmland of southeastern Wisconsin and the Port of Milwaukee. In 1835, Charles Hart became the first Euro-American to settle here, followed that year by 17 other families. The following year a United States Road was built from Milwaukee through Wauwatosa, eventually reaching Madison. Charles Hart built a mill in 1845 on the Menomonee River which gave the settlement its original name of "Hart's Mill." The mill was torn down in 1914. The Town of Wau-wau-too-sa was created by act of the Wisconsin Territorial Legislature on April 30, 1840. As o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gram-negative
Gram-negative bacteria are bacteria that, unlike gram-positive bacteria, do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. Their defining characteristic is that their cell envelope consists of a thin peptidoglycan cell wall sandwiched between an inner ( cytoplasmic) membrane and an outer membrane. These bacteria are found in all environments that support life on Earth. Within this category, notable species include the model organism '' Escherichia coli'', along with various pathogenic bacteria, such as '' Pseudomonas aeruginosa'', '' Chlamydia trachomatis'', and '' Yersinia pestis''. They pose significant challenges in the medical field due to their outer membrane, which acts as a protective barrier against numerous antibiotics (including penicillin), detergents that would normally damage the inner cell membrane, and the antimicrobial enzyme lysozyme produced by animals as part of their innate immune system. Furthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, Hot spring, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the nitrogen fixation, fixation of nitrogen from the Earth's atmosphere, atmosphere. The nutrient cycle includes the decomposition of cadaver, dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francisella
''Francisella'' is a genus of Gram-negative bacteria. They are small coccobacillary or rod-shaped, nonmotile organisms, which are also facultative intracellular parasites of macrophages. Strict aerobes, ''Francisella'' colonies bear a morphological resemblance to those of the genus ''Brucella''. Some ''Francisella'' species are pathogenic bacteria but some others are endosymbionts of ticks. Ticks do not use any other food source than vertebrate blood and therefore ingest high levels of protein, iron and salt, but few vitamins. To overcome these nutritional deficiencies, ticks have evolved obligate interactions with nutritional endosymbionts, including ''Francisella'' endosymbionts. Their experimental elimination typically results in decreased tick survival, molting, fecundity and egg viability, as well as in physical abnormalities, which all are fully restored with an oral supplement of B vitamins. The genome sequencing of ''Francisella'' endosymbionts confirmed that they consi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
