Caroxazone Synthesis
Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of major depressive disorder, depression but is now no longer marketed. It acts as a Enzyme inhibitor#Reversible inhibitors, reversible monoamine oxidase inhibitor (Reversible inhibitor of monoamine oxidase A, RIMA) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter. Synthesis Synthesis starts by reductive amination of salicylaldehyde and glycinamide to give 3. The synthesis is completed by reaction with phosgene and NaHCO3, NaHCO3. See also * Paraxazone, an isomer of Caroxazone References

{{Monoamine metabolism modulators Benzoxazines Carbamates ...
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Diário Oficial Da União
The ''Diário Oficial da União'' (literally ''Official Diary of the Union''), abbreviated DOU, is the government gazette, official gazette of the Federal Government of Brazil, Federal Government of Brazil. It is published since 1 October 1862 and was created via the Imperial Decree 1,177 of its 9 September as the ''Official Journal of the Empire of Brazil''. Its current name was adopted after Brazil became a federal republic, and the "Union" came into being as the legal personality of the new federal government. The official journal is published by the Imprensa Nacional, Brazilian National Press. Though the journal has been published since 1862, it had many predecessors, as follows: # Gazeta do Rio de Janeiro (10/9/1808 – 29.12.1821) # Gazeta do Rio (1/1/1822 – 31/12/1822) # Diário do Governo (2/1/1823 – 28/6/1833) # Diário Fluminense (21/5/1824 – 24/4/1831) # Correio Oficial (1/7/1833 – 30/6/1836) e (2/1/1830 – 30/12/1840) # Without proper journal (31/12/1840 – ...
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