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Carlos F. Barbas III
Carlos F. Barbas III (5 November 1964 – 24 June 2014) was chair professor of the Janet and Keith Kellogg II and a chemist at the Scripps Research Institute. Barbas developed new therapies that can target HIV-1 and some kinds of cancer which went into clinical trials. Early years and education Barbas was born on 5 November 1964 and he was raised up in St. Petersburg, Florida. After a few years, Barbas cultivated interests in physics and chemistry subjects and graduated from Eckerd College with honors. In 1989, he finished his PhD in Organic Chemistry under Chi-Huey Wong at the Texas A&M University. Career From 1981 to 1991, Barbas started postdoctoral studies with Stephen J. Benkovic at the Pennsylvania State University, and began doing research with Richard Lerner at The Scripps Research Institute. From 1991 to 1995, he was assistant professor in the department of molecular biology at Scripps, where his studies emphasized on the developing new therapies against human dise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acid Sequence
A nucleic acid sequence is a succession of Nucleobase, bases within the nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule. This succession is denoted by a series of a set of five different letters that indicate the order of the nucleotides. By convention, sequences are usually presented from the Directionality (molecular biology), 5' end to the 3' end. For DNA, with its double helix, there are two possible directions for the notated sequence; of these two, the Sense (molecular biology), sense strand is used. Because nucleic acids are normally linear (unbranched) polymers, specifying the sequence is equivalent to defining the covalent structure of the entire molecule. For this reason, the nucleic acid sequence is also termed the Biomolecular structure#Primary structure, primary structure. The sequence represents genetic information. Biological deoxyribonucleic acid represents the information which directs the functions of an organism. Nucleic acids also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For The Advancement Of Science
The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education, scientific education and science outreach for the betterment of all humanity. AAAS was the first permanent organization established to promote science and engineering nationally and to represent the interests of American researchers from across all scientific fields. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal ''Science (journal), Science''. History Creation The American Association for the Advancement of Science was created on September 20, 1848, at the Academy of Natural Sciences in Philadelphia, Pennsylvania. It was a reformation of the Association of American Geologists and Naturalists with the broaden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c) organization, 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 80 Scientific journal, scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur C
Arthur is a masculine given name of uncertain etymology. Its popularity derives from it being the name of the legendary hero King Arthur. A common spelling variant used in many Slavic, Romance, and Germanic languages is Artur. In Spanish and Italian it is Arturo. Etymology The earliest attestation of the name Arthur is in the early 9th century Welsh-Latin text '' Historia Brittonum'', where it refers to a circa 5th century Romano-British general who fought against the invading Saxons, and who later gave rise to the famous King Arthur of medieval legend and literature. A possible earlier mention of the same man is to be found in the epic Welsh poem '' Y Gododdin'' by Aneirin, which some scholars assign to the late 6th century, though this is still a matter of debate and the poem only survives in a late 13th century manuscript entitled the Book of Aneirin. A 9th-century Breton landowner named Arthur witnessed several charters collected in the '' Cartulary of Redon''. The Irish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Research Institute
The Cancer Research Institute (CRI) is a US non-profit organization funding cancer research and based in New York City. They were founded in 1953 to develop immunologically-based treatments for cancer, and despite their name are a funding body for research rather than a research institute themselves, working with other institutes and organizations. It was founded by Helen Coley Nauts and Oliver R. Grace with a $2,000 grant from Nelson Rockefeller. CRI was created in honor of Nauts' father, William Coley (1862–1936), an American orthopedic surgeon and a pioneer of cancer immunotherapy. Grounded in Dr. Coley’s pioneering work, the Cancer Research Institute focuses on immunological treatments for cancer, both as a single treatment approach as well as a complement and enhancer to traditional treatments, such as chemotherapy and surgery Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma, di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AmfAR
amfAR, the Foundation for AIDS Research, known until 2005 as the American Foundation for AIDS Research, is an international nonprofit organization dedicated to the support of AIDS research, HIV prevention, treatment education, and the advocacy of AIDS-related public policy. amfAR is a tax-exempt corporation under Internal Revenue Code section 501(c)(3) and operates as an independent nonprofit with worldwide initiatives. amfAR was formed in September 1985 by actress Elizabeth Taylor, Michael Gottleib, Mathilde Krim, physician Joseph Sonnabend, and activist Michael Callen. The organization was created when Taylor and Gottleib’s California-based National AIDS Research Foundation, which sought to actively engage in HIV-related drug development, merged with Krim’s New York-based AIDS Medical Foundation (AMF), which sought to lessen the stigma surrounding HIV/AIDS diagnoses, as well as to increase funding to the cause. What resulted was a foundation that prioritized both research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scopus
Scopus is a scientific abstract and citation database, launched by the academic publisher Elsevier as a competitor to older Web of Science in 2004. The ensuing competition between the two databases has been characterized as "intense" and is considered to significantly benefit their users in terms of continuous improvement in coverage, search/analysis capabilities, but not in price. Free database The Lens completes the triad of main universal academic research databases. Journals in Scopus are reviewed for sufficient quality each year according to four numerical measures: ''h''-Index, CiteScore, SJR ( SCImago Journal Rank) and SNIP ( source normalized impact per paper). For this reason, the journals listed in Scopus are considered to meet the requirement for peer review quality established by several research grant agencies for their grant recipients and by degree-accreditation boards in a number of countries. Scopus also allows patent searches from a dedicated patent dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Google Scholar
Google Scholar is a freely accessible web search engine that indexes the full text or metadata of Academic publishing, scholarly literature across an array of publishing formats and disciplines. Released in Beta release, beta in November 2004, the Google Scholar index includes peer-reviewed online academic journals and books, conference papers, theses and dissertations, preprints, Abstract (summary), abstracts, technical reports, and other scholarly literature, including Legal opinion, court opinions and patents. Google Scholar uses a web crawler, or web robot, to identify files for inclusion in the search results. For content to be indexed in Google Scholar, it must meet certain specified criteria. An earlier statistical estimate published in PLOS One using a mark and recapture method estimated approximately 79–90% coverage of all articles published in English with an estimate of 100 million.'' Trend Watch'' (2014) Nature (journal), Nature 509(7501), 405 – discussing Madian K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H-index
The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with success indicators such as winning the Nobel Prize, being accepted for research fellowships and holding positions at top universities. The index is based on the set of the scientist's most cited papers and the number of citations that they have received in other publications. The index has more recently been applied to the productivity and impact of a scholarly journal as well as a group of scientists, such as a department or university or country. The index was suggested in 2005 by Jorge E. Hirsch, a physicist at UC San Diego, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number. Hirsch intended the ''h''-index to address the main disadvantages of other bibliometric indicators. The total number of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Triphosphates
A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose), with three phosphate groups bound to the sugar. They are the molecular precursors of both DNA and RNA, which are chains of nucleotides made through the processes of DNA replication and transcription. Nucleoside triphosphates also serve as a source of energy for cellular reactions and are involved in signalling pathways. Nucleoside triphosphates cannot easily cross the cell membrane, so they are typically synthesized within the cell. Synthesis pathways differ depending on the specific nucleoside triphosphate being made, but given the many important roles of nucleoside triphosphates, synthesis is tightly regulated in all cases. Nucleoside analogues may also be used to treat viral infections. For example, azidothymidine (AZT) is a nucleoside analogue used to prevent and treat HIV/AIDS. Naming The term nucleoside refers to a nitrogenous base linked to a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
