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CankerMelts
CankerMelts is a non-prescription over-the-counter medication produced by Orahealth Corporation, located in Bellevue, Washington. CankerMelts are used to treat canker sores (aphthous ulcer) and other trauma-based mouth ailments. The product's active ingredient is ''Glycyrrhiza'' extract (GX), which comes from the root of the licorice plant. GX is thought to have pain relieving, anti-inflammatory, and anti-bacterial properties. CankerMelts are time-released dissolving discs that adhere in the mouth in order to deliver a GX-collagen mix directly to the affected area. The disc dissolves in the mouth, slowly releasing the GX and collagen over two to six hours. Research shows that this mix may reduce the healing time of the canker sores from one to two weeks to three to five days. Testing and research The results of a 2006 National Institutes of Health – National Institute of Dental and Craniofacial Research funded study at the University of Washington The University of Washing ...
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Aphthous Ulcer
Aphthous stomatitis, or recurrent aphthous stomatitis (RAS), commonly referred to as a canker sore or salt blister, is a common condition characterized by the repeated formation of benignity, benign and non-contagious disease, contagious mouth ulcers (aphthae) in otherwise healthy individuals. The cause is not completely understood but involves a T cell-mediated immune response triggered by a variety of factors which may include nutritional deficiencies, local Physical trauma, trauma, Stress (biology), stress, hormonal influences, allergies, genetic predisposition, certain foods, dehydration, some food additives, or some hygienic chemical additives like Sodium dodecyl sulfate#Mouth ulceration, SDS (common in toothpaste). These ulcers occur periodically and heal completely between attacks. In the majority of cases, the individual ulcers last about 7–10 days, and ulceration episodes occur 3–6 times per year. Most appear on the Stratified squamous epithelium#Non-keratinized, n ...
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Bellevue, Washington
Bellevue ( ) is a city in the Eastside (King County, Washington), Eastside region of King County, Washington, United States, located across Lake Washington from Seattle. It is the third-largest city in the Seattle metropolitan area, and the fifth-largest city in Washington (state), Washington. It has variously been characterized as a satellite city, a suburb, a boomburb, or an edge city. The population was 151,854 at the 2020 United States census, 2020 census. The city's name is derived from the French term ("beautiful view"). Bellevue is home to some of the world's largest technology companies. Before and after the 2008 recession, its downtown area has been undergoing rapid change with many high-rise projects being constructed. Downtown Bellevue is currently the second-largest city center in Washington state, with 1,300 businesses, 45,000 employees, and 10,200 residents. In a 2018 estimate, the city's median household income was among the top five cities in the state of Wash ...
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Glycyrrhiza
''Glycyrrhiza'' is a genus of about 20 accepted species in the legume family (Fabaceae), with a subcosmopolitan distribution in Asia, Australia, Europe, and the Americas. The genus is best known for liquorice (British English; licorice in American English), ''G. glabra'', a species native to Eurasia and North Africa, from which most confectionery liquorice is produced. Species 17 species are accepted: *'' Glycyrrhiza acanthocarpa'' *'' Glycyrrhiza aspera'' *'' Glycyrrhiza astragalina'' *'' Glycyrrhiza asymmetrica'' *'' Glycyrrhiza bucharica'' *''Glycyrrhiza echinata'' *'' Glycyrrhiza foetida'' *''Glycyrrhiza glabra Liquorice (Commonwealth English) or licorice (American English; see spelling differences; ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is ...'' – liquorice, licorice *'' Glycyrrhiza gontscharovii'' *'' Glycyrrhiza inflata'' *'' Glycyrrhiza lepi ...
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Licorice
Liquorice (Commonwealth English) or licorice (American English; see spelling differences; ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is extracted. The liquorice plant is an herbaceous perennial legume native to West Asia, North Africa, and Southern Europe. Liquorice is used as a flavouring in confectionery, tobacco, beverages, and pharmaceuticals, and is marketed as a dietary supplement. Liquorice extracts have been used in herbalism and traditional medicine. Excessive consumption of liquorice (more than per day of pure glycyrrhizinic acid, a key component of liquorice) can lead to undesirable consequences. Clinically, it is suspected that overindulgence in liquorice may manifest as unexplained hypertension, low blood potassium levels ( hypokalemia), and muscle weakness in individuals. Consuming liquorice should be avoided during pregnancy. Etymology The word ''liquo ...
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Collagen
Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in cartilage, bones, tendons, ligaments, and skin. Vitamin C is vital for collagen synthesis. Depending on the degree of biomineralization, mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the Gut (anatomy), gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. The fibroblast is the most common cell creating collagen in animals. Gelatin, which is used in food and industry, is collagen t ...
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National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ...
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National Institute Of Dental And Craniofacial Research
The National Institute of Dental and Craniofacial Research (NIDCR) is a branch of the U.S. National Institutes of Health. The institute aims to improve the oral, dental, and craniofacial health through research and the distribution of important health information to the American people. History In 1931, the United States Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services which manages public health, containing nine out of the department's twelve operating divisions. The assistant s ... established a Dental Hygiene Unit at the National Institutes of Health. Designated as the first dental research worker, Dr. H. Trendley Dean studied the communities affected by the oral disease known as mottled enamel. Following the implementation of a water fluoridation trial in Grand Rapids, Michigan, the National Institute of Dental Research (NIDR), was established by President Harry S ...
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University Of Washington
The University of Washington (UW and informally U-Dub or U Dub) is a public research university in Seattle, Washington, United States. Founded in 1861, the University of Washington is one of the oldest universities on the West Coast of the United States. The university has a main campus located in the city's University District. It also has satellite campuses in nearby cities of Tacoma and Bothell. Overall, UW encompasses more than 500 buildings and over 20 million gross square footage of space, including one of the largest library systems in the world with more than 26 university libraries, art centers, museums, laboratories, lecture halls, and stadiums. Washington is the flagship institution of the six public universities in Washington State. It is known for its medical, engineering, and scientific research. Washington is a member of the Association of American Universities. According to the National Science Foundation, UW spent $1.73 billion on research and develo ...
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Oral Hygiene
Oral hygiene is the practice of keeping one's oral cavity clean and free of disease and other problems (e.g. bad breath) by regular brushing of the teeth (dental hygiene) and adopting good hygiene habits. It is important that oral hygiene be carried out on a regular basis to enable prevention of dental disease and bad breath. The most common types of dental disease are tooth decay (''cavities'', ''dental caries'') and gum diseases, including gingivitis, and periodontitis. General guidelines for adults suggest brushing at least twice a day with a fluoridated toothpaste: brushing before going to sleep at night and after breakfast in the morning. Cleaning between the teeth is called interdental cleaning and is as important as tooth brushing. This is because a toothbrush cannot reach between the teeth and therefore only removes about 50% of plaque from the surface of the teeth. There are many tools available for interdental cleaning which include Dental floss, floss, tape and interden ...
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