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CVac
CVac (short for Cancer Vaccine), is an immunotherapeutic agent that was first developed in Australia. CVac was developed by the biotechnology company Prima BioMed (Nasdaq: PBMD) through to Phase II clinical studies between 2001 and 2015. After inconclusive clinical data in ovarian cancer 2013 and 2014, Prima announced in February 2015 that it had ceased recruiting into CVAc clinical studies and was seeking commercial partners for the product. Treatment method CVac is an '' ex vivo'' dendritic cell priming technology involving MFP, or mannan fusion protein, where a fusion protein of MUC1 and Glutathione S-transferase is coupled to oxidized polymannose. The dendritic cells are the orchestrators of the immune system. 'Priming' dendritic cells involves exposing those cells to disease antigens in order to get the immune system to properly recognise the antigen and mount an appropriate response. With CVac this takes place outside the body of the patient (''ex vivo''), with dendritic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prima BioMed
Immutep Ltd (formerly Prima Biomed) is a biotechnology company working primarily in the field of cancer immunotherapy using the LAG3 immune control mechanism. The company was originally built on CVac, a therapeutic cancer vaccine. In late 2014 the privately held French immunotherapy company Immutep SA was purchased by Prima Biotech. Prima currently has three main products in its pipeline, all acquired with Immutep: Eftilagimod alpha, (lab name: IMP321) which is recombinant soluble LAG-3, used as an activator of antigen presenting cells. This product has completed a Phase IIa clinical study, where it doubled the expected response rate in HER2-negative metastatic breast cancer. IMP731, a depleting monoclonal antibody for autoimmune diseases, targeting LAG-3+ activated T cells. This antibody has been licensed to GlaxoSmithKline. IMP701, an antagonist monoclonal antibody to LAG3 for use in cancer. This product has been licensed to Novartis History Immutep (formerly Prima B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunotherapy
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherapies that reduce or suppress are classified as '' suppression immunotherapies''. Immunotherapy is under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. Vaccine-induced immunity to COVID-19 relies mostly on an immunomodulatory T cell response. Therapies such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and cellular membrane fractions from bacteria are licensed for medical use. Others incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Austin Hospital, Melbourne
The Austin Hospital is a public teaching hospital in Melbourne's north-eastern suburb of Heidelberg, and is administered by Austin Health, along with the Heidelberg Repatriation Hospital and the Royal Talbot Rehabilitation Centre. History The Austin Hospital was founded in 1882 as a charitable institution for incurables by Elizabeth Austin, the widow of Thomas Austin. It had several name changes before becoming the Austin Hospital.History Austin Hospital, retrieved 2009-03-03. War and post-war During World War II, two s were located at the site - the 115th Australian General Hospital, operated by the |
Leipzig
Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as well as the second most populous city in the area of the former East Germany after ( East) Berlin. Together with Halle (Saale), the city forms the polycentric Leipzig-Halle Conurbation. Between the two cities (in Schkeuditz) lies Leipzig/Halle Airport. Leipzig is located about southwest of Berlin, in the southernmost part of the North German Plain (known as Leipzig Bay), at the confluence of the White Elster River (progression: ) and two of its tributaries: the Pleiße and the Parthe. The name of the city and those of many of its boroughs are of Slavic origin. Leipzig has been a trade city since at least the time of the Holy Roman Empire. The city sits at the intersection of the Via Regia and the Via Imperii, two important medie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fraunhofer Society
The Fraunhofer Society (german: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., lit=Fraunhofer Society for the Advancement of Applied Research) is a German research organization with 76institutes spread throughout Germany, each focusing on different fields of applied science (as opposed to the Max Planck Society, which works primarily on basic science). With some 29,000 employees, mainly scientists and engineers, and with an annual research budget of about €2.8billion, it is the biggest organization for applied research and development services in Europe. Some basic funding for the Fraunhofer Society is provided by the state (the German public, through the federal government together with the states or ''Länder'', "owns" the Fraunhofer Society), but more than 70% of the funding is earned through contract work, either for government-sponsored projects or from industry. It is named after Joseph von Fraunhofer who, as a scientist, an engineer, and an e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany, officially the Federal Republic of Germany (FRG),, is a country in Central Europe. It is the most populous member state of the European Union. Germany lies between the Baltic and North Sea to the north and the Alps to the south. Its 16 constituent states have a total population of over 84 million in an area of . It borders Denmark to the north, Poland and Czechia to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its main financial centre is Frankfurt; the largest urban area is the Ruhr. Settlement in what is now Germany began in the Lower Paleolithic, with various tribes inhabiting it from the Neolithic onward, chiefly the Celts. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dubai Health Authority
The Dubai Health Authority (DHA) is a government organization overseeing the health system of Dubai, United Arab Emirates. Background The Dubai Health Authority (DHA) was formed in 2007 under the directives of Sheikh Mohammed bin Rashid Al Maktoum, the Vice President, Prime Minister, and Ruler of Dubai. The program was launched in March 2008. Before the DHA was established, the body overseeing healthcare in the emirate was known as the Department of Health and Medical Services, which was established in 1973. Beyond general oversight of Dubai's healthcare sector the DHA provides healthcare services through hospitals and other facilities that fall under its direct jurisdiction. These include Latifa Hospital, Dubai Hospital, Rashid Hospital and Hatta Hospital, in addition to other specialty centres and DHA primary health centres throughout Dubai. Other aspects of the DHA's services are: *Creating and ensuring the execution of policies and strategies for healthcare in Dubai's p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse Takeover
A reverse takeover (RTO), reverse merger, or reverse IPO is the acquisition of a public company by a private company so that the private company can bypass the lengthy and complex process of going public. Sometimes, conversely, the public company is bought by the private company through an asset swap and share issue. The transaction typically requires reorganization of capitalization of the acquiring company. Process In a reverse takeover, shareholders of the private company purchase control of the public shell company/ SPAC and then merge it with the private company. The publicly traded corporation is called a "shell" since all that exists of the original company is its organizational structure. The private company shareholders receive a substantial majority of the shares of the public company and control of its board of directors. The transaction can be accomplished within weeks. The transaction involves the private and shell company exchanging information on each other, ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burnet Institute
The Burnet Institute is an Australian medical institute that combines medical research in the laboratory and the field, with public health action to address major health issues affecting disadvantaged communities in Australia, and internationally. As of 2011, the institute was home to more than 450 medical researchers, working across six main themes: infectious diseases; maternal and child health; sexual and reproductive health; alcohol and other drugs harm reduction; immunity, vaccines and immunisation; and the health of young people. With a head office located in Commercial Road, Prahran, Victoria, the institute delivers public health programs across four continents including Africa, Oceania, and Asia and is led by its director and chief executive officer, Professor Brendan Crabb , an immunologist. Current research Burnet Institute has particular expertise in infectious diseases (especially HIV, hepatitis viruses, influenza and malaria) and in understanding the immune ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leukapheresis
Leukapheresis () is a laboratory procedure in which white blood cells are separated from a sample of blood. It is a specific type of apheresis, the more general term for separating out one particular constituent of blood and returning the remainder to the circulation. Leukapheresis may be performed to decrease a very high white blood cell count, to obtain blood cells from a patient (autologous) or donor ( allogeneic) for later transplant into the patient, or to obtain cells for research purposes. In the case of hematological malignancies such as chronic leukemias, white blood cell counts may be high enough to cause leukostasis and "sludging" in the capillaries (acute leukemias have a more variable white cell count whereas chronic cases typically have higher white cell counts). This can affect retinal vasculature leading to vision changes, pulmonary vasculature leading to shortness of breath from decreased efficiency in oxygen exchange, as well as other organ systems such as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Australia
Australia, officially the Commonwealth of Australia, is a sovereign ''Sovereign'' is a title which can be applied to the highest leader in various categories. The word is borrowed from Old French , which is ultimately derived from the Latin , meaning 'above'. The roles of a sovereign vary from monarch, ruler or ... country comprising the mainland of the Australian continent, the island of Tasmania, and numerous smaller islands. With an area of , Australia is the largest country by area in Oceania and the world's sixth-largest country. Australia is the oldest, flattest, and driest inhabited continent, with the least fertile soils. It is a megadiverse country, and its size gives it a wide variety of landscapes and climates, with deserts in the centre, tropical Forests of Australia, rainforests in the north-east, and List of mountains in Australia, mountain ranges in the south-east. The ancestors of Aboriginal Australians began arriving from south east Asia approx ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutathione S-transferase
Glutathione ''S''-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions. GSTs can constitute up to 10% of cytosolic protein in some mammalian organs. GSTs catalyse the conjugation of GSH—via a sulfhydryl group—to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. This activity detoxifies endogenous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
