|
Biogerontology
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal '' Biogerontology'' in 2000. It involves interdisciplinary research on the causes, effects, and mechanisms of biological aging. Biogerontologist Leonard Hayflick has said that the natural average lifespan for a human is around 92 years and, if humans do not invent new approaches to treat aging, they will be stuck with this lifespan. James Vaupel has predicted that life expectancy in industrialized countries will reach 100 for children born after the year 2000. Many surveyed biogerontologists have predicted life expectancies of more than three centuries for people born after the year 2100. Other scientists, more controversially, suggest the possibility of unlimited lifespans for those currently living. For examp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suresh Rattan
Suresh Rattan (full name: ''Suresh Inder Singh Rattan''; born in 1955 in Amritsar, India) is a Biogerontologist#Biogerontology, biogerontologist – a researcher in the field of biology of ageing, biogerontology. In addition to his professional research work on the biology of ageing, he is also very much interested and involved in the public communication of science and he likes to undertake explorations in the Indian classical music and semi-classical music by playing Tabla – the North Indian drums, as evident from music CDs "State of the Art: Small Town People" by Harry Jokumsen and other artists (2008), and "The Fall and the Rise of a Woman" by Pearl (2014) in which he plays Tabla under his artistic name Shashi Maharaj. Academic background Suresh Rattan has been heading, since its inception in 1984, the Laboratory of Cellular Ageing at the Department of Molecular Biology and Genetics at the Aarhus University in Denmark, where he has become Emeritus since 2020. He was intro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biogerontology (journal)
''Biogerontology'' is a bimonthly peer-reviewed scientific journal published by Springer Science+Business Media. It covers research on the biological mechanisms of ageing. The founding editor-in-chief is Suresh Rattan. In 2023, its impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... was 4.4. External links *{{Official website, https://www.springer.com/journal/10522 Gerontology journals Springer Science+Business Media academic journals Academic journals established in 2000 English-language journals Bimonthly journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Gerontology
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several researchers in the area, along with "life extensionists", " immortalists", or " longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists. The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerontology
Gerontology ( ) is the study of the social, culture, cultural, psychology, psychological, cognitive, and biology, biological aspects of aging. The word was coined by Ilya Ilyich Mechnikov in 1903, from the Ancient Greek, Greek ('), meaning "old man", and ('), meaning "study of". The field is distinguished from geriatrics, which is the branch of medicine that specializes in the treatment of existing disease in older adults. Gerontologists include researchers and practitioners in the fields of biology, nursing, medicine, criminology, dentistry, social work, physical and occupational therapy, psychology, psychiatry, sociology, economics, political science, architecture, geography, pharmacy, public health, housing, and anthropology. The multidisciplinarity, multidisciplinary nature of gerontology means that there are a number of sub-fields which overlap with gerontology. There are policy issues, for example, involved in government planning and the operation of nursing homes, inve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ending Aging
''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime'' is a 2007 book written by biogerontologist Aubrey de Grey, with his research assistant Michael Rae. ''Ending Aging'' describes de Grey's proposal for eliminating aging as a cause of debilitation and death in humans, and restoring the body to an indefinitely youthful state, a project that he calls the "strategies for engineered negligible senescence" ("SENS"). De Grey argues that defeating aging is feasible, possibly within a few decades, and he outlines steps that can be taken to hasten the development of regenerative medicine treatments for each side of aging. Editions * St. Martin's Press, 1st edition ''(hardcover, 389 pages)'', released September 4, 2007: * St. Martin's Griffin, 1st reprint edition with new afterword ''(paperback, 448 pages)'', released October 14, 2008: Translations * German: Niemals alt!: So lässt sich das Altern umkehren. Fortschritte der Verjüngungsfors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senescence
Senescence () or biological aging is the gradual deterioration of Function (biology), functional characteristics in living organisms. Whole organism senescence involves an increase in mortality rate, death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's biological life cycle, life cycle. However, the resulting effects of senescence can be delayed. The 1934 discovery that calorie restriction can Life extension, extend lifespans by 50% in rats, the existence of species having negligible senescence, and the existence of potentially immortal organisms such as members of the genus ''Hydra (genus), Hydra'' have motivated research into Life extension, delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases. Environmental Gerontogens, factors may affect aging – for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body may age at different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maximum Life Span
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity. Most living species have an upper limit on the number of times somatic cells not expressing telomerase can divide. This is called the Hayflick limit, although this number of cell divisions does not strictly control lifespan. Definition In animal studies, maximum span is often taken to be the mean life span of the most long-lived 10% of a given cohort. By another definition, however, maximum life span corresponds to the age at which the oldest known member of a species or experimental group has died. Calculation of the maximum life span in the latter sense depends upon the init ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strategies For Engineered Negligible Senescence
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease.de Grey, Aubrey; Rae, Michael (September 2007). ''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime''. New York, NY: St. Martin's Press, 416 pp. . SENS was first defined by British biogerontologist Aubrey de Grey. Many mainstream scientists believe that it is a fringe theory. De Grey later highlighted similarities and differences of SENS to subsequent categorization systems of the biology of aging, such as the highly influential ''Hallmarks of Aging'' published in 2013. While some biogerontologists support the SENS program, others contend that the ultimate goals of de Grey's programme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aging-associated Diseases
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age ( with rare exceptions) but not all adult animals experience all age-associated diseases. The term does not refer to age-specific diseases, such as the childhood diseases chicken pox and measles, only diseases of the elderly. They are also not accelerated aging diseases, all of which are genetic disorders. Examples of aging-associated diseases are atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease. The incidence of all of these diseases increases exponentially with age. Of the roughly 150,000 people who die each day across the globe, about two thirds—100,000 per day—die of age-related causes. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Hayflick
Leonard Hayflick (May 20, 1928 – August 1, 2024) was an American anatomist who was Professor of Anatomy at the UCSF School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine. He was also past president of the Gerontological Society of America and was a founding member of the council of the National Institute on Aging (NIA). The recipient of a number of research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, he studied the senescence, ageing process for more than fifty years. He is known for discovering that normal human Cell (biology), cells divide for a limited number of times ''in vitro'' (refuting the contention by Alexis Carrel that normal body cells are biological immortality, immortal). This is known as the Hayflick limit. His discoveries overturned a 60-year old dogma that all cultured cells are immortal. Hayflick demonstrated that normal cells have a memory and can remember what doubling le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aubrey De Grey
Aubrey David Nicholas Jasper de Grey (; born 20 April 1963) is an English biomedical gerontologist. He is the author of ''The Mitochondrial Free Radical Theory of Aging'' (1999) and co-author of '' Ending Aging'' (2007). De Grey is known for his view that medical technology may enable human beings alive today not to die from age-related causes. As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in geometric graph theory, making the first progress on the problem in over 60 years. De Grey is an international adjunct professor of the Moscow Institute of Physics and Technology. In August 2021, he was removed as the Chief Science Officer of the SENS Research Foundation after he had allegedly attempted to interfere in a probe investigating sexual harassment allegations against him. In September 2021, an independent investigation concluded that he had made offensive remarks to two women. Early life and education De Grey was born on 20 Apr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
August Weismann
August Friedrich Leopold Weismann (; 17 January 18345 November 1914) was a German evolutionary biology, evolutionary biologist. Fellow German Ernst Mayr ranked him as the second most notable evolutionary theorist of the 19th century, after Charles Darwin. Weismann became the Director of the Zoological Institute and the first Professor of Zoology at University of Freiburg, Freiburg. His main contribution involved germ plasm theory, at one time also known as Weismannism,Romanes, George John. ''An examination of Weismannism''. The Open court publishing company in Chicago 189/ref> according to which inheritance (in a multicellular animal) only takes place by means of the germ cells—the gametes such as egg cells and sperm cells. Other cells of the body—somatic cells—do not function as agents of heredity. The effect is one-way: germ cells produce somatic cells and are not affected by anything the somatic cells learn or therefore any ability an individual acquires during its life. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
