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Bulbocapnine
Bulbocapnine is an alkaloid found in ''Corydalis'' (notably the European species C. cava) and '' Dicentra'', genera of the plant family Fumariaceae which have caused (notably the American species '' Corydalis caseana'') the fatal poisoning of sheep and cattle. It has been shown to act as an acetylcholinesterase inhibitor, and inhibits biosynthesis of dopamine via inhibition of the enzyme tyrosine hydroxylase. Like apomorphine, it is reported to be an inhibitor of amyloid beta protein (Aβ) fiber formation, whose presence is a hallmark of Alzheimer's disease (AD). Bulbocapnine is thus a potential therapeutic under the amyloid hypothesis. According to the ''Dorlands Medical Dictionary'', it "inhibits the reflex and motor activities of striated muscle. It has been used in the treatment of muscular tremors and vestibular nystagmus". A psychiatrist at Tulane University named Robert Heath carried out experiments on prisoners at the Louisiana State Penitentiary using bulbocapnine t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nantenine
Nantenine is an alkaloid found in the plant ''Nandina domestica'' as well as some ''Corydalis'' species. It is an antagonist of both the α1-adrenergic receptor and the serotonin 5-HT2A receptor, and blocks both the behavioral and physiological effects of MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ... in animals. See also References 5-HT2A antagonists Alpha-1 blockers Antidotes Aporphine alkaloids Phenol ethers {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glaucine
Glaucine is an aporphine alkaloid found in several different plant species in the family Papaveraceae such as ''Glaucium flavum'', '' Glaucium oxylobum'' and '' Corydalis yanhusuo'', and in other plants like ''Croton lechleri'' in the family Euphorbiaceae. It has bronchodilator, neuroleptic and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. TLRs plays role in its anti inflammatory effects. Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterised by colourful visual images, and has been detected as a novel psychoactive drug. In a 2019 publication,Heng, HL, Chee, CF, Thy, CK, et al. In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5‐HT2 and α1 receptors. Chem Biol Drug Des. 2019; 93: 132– 138. https://doi.org/10.1111/cbdd.13390 the isomer (R)-glaucine is reported to be a positive allosteric modulator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydalis Cava
''Corydalis cava'' is a species of flowering plant in the family Papaveraceae, native to moist, shady, woodland habitats throughout most of mainland Europe, although commonest in central and southeast Europe. Its range extends from Spain in the west to Ukraine, Belarus and the Caucasus in the east and as far north as Sweden. It is absent from (though may sometimes be found in a naturalised state in) Iceland, the UK, the Netherlands, Norway, Finland, Russia and Greece. Description ''Corydalis cava'' grows to tall. It is a spring ephemeral—foliage that grows in the spring dies down to its tuberous rootstock in summer. It has long-spurred flowers which appear in spring. The flowers may be mauve, purple, red, or white. The seeds contain an elaiosome that attracts ants, which transport the seeds into their ant colony. This seed transportation is called myrmecochory. Toxicity Many of the species in ''Corydalis'' contain alkaloids such as canadine and corydaline, which blocks ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tulane University
Tulane University, officially the Tulane University of Louisiana, is a private research university in New Orleans, Louisiana. Founded as the Medical College of Louisiana in 1834 by seven young medical doctors, it turned into a comprehensive public university as the University of Louisiana by the state legislature in 1847. The institution became private under the endowments of Paul Tulane and Josephine Louise Newcomb in 1884 and 1887. Tulane is the 9th oldest private university in the Association of American Universities. The Tulane University Law School and Tulane University Medical School are, respectively, the 12th oldest law school and 15th oldest medical school in the United States. Tulane has been a member of the Association of American Universities since 1958 and is classified among "R1: Doctoral Universities – Very high research activity". Tulane has an overall acceptance rate of 8.4%. Alumni include twelve governors of Louisiana; one Chief Justice of the United ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apomorphine
Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non- selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. It also acts as an antagonist of 5-HT2 and α-adrenergic receptors with high affinity. The compound is historically a morphine decomposition product made by boiling morphine with concentrated acid, hence the ''-morphine'' suffix. Contrary to its name, apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. The ''apo-'' prefix relates to it being a morphine derivative (" omesfrom morphine"). Historically, apomorphine has been tried for a variety of uses, including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals, and more recently in treating erectile dysfunction. Currently, apomorphine is used in the treatment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boss (TV Series)
''Boss'' is an American political drama television serial created by Farhad Safinia. The series stars Kelsey Grammer as Tom Kane, the mayor of Chicago, who has recently been diagnosed with Lewy body dementia, a degenerative neurological disorder. The series was broadcast in the United States on the premium television service Starz and was produced by Category 5 Entertainment, Grammnet Productions and Lionsgate Television. On September 27, 2011, before the series premiered, Starz announced that ''Boss'' had been renewed for a second season of ten episodes. The first season premiered on October 21, 2011 and the second season premiered on August 17, 2012. On November 20, 2012, it was announced that Starz had cancelled the show. A film was discussed to finish the show's storylines, but those plans were cancelled after series creator Farhad Safinia declined to move forward with the project. Overview As the series commences we follow Tom Kane, the Mayor of Chicago, who has been d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naked Lunch
''Naked Lunch'' (sometimes ''The Naked Lunch'') is a 1959 novel by American writer William S. Burroughs. The book is structured as a series of loosely connected vignettes, intended by Burroughs to be read in any order. The reader follows the narration of junkie William Lee, who takes on various aliases, from the U.S. to Mexico, eventually to Tangier and the dreamlike Interzone. The vignettes (which Burroughs called "routines") are drawn from Burroughs' own experiences in these places and his addiction to drugs: heroin, morphine and, while in Tangier, majoun (a strong hashish confection), as well as a German opioid with the brand name Eukodol (oxycodone), of which he wrote frequently. The novel was included in ''Times "100 Best English-language Novels from 1923 to 2005". In 1991, David Cronenberg directed a film of the same name based on the novel and other Burroughs writings. Title origin The book was originally published with the title ''The Naked Lunch'' in Paris in Ju ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William S
William is a masculine given name of Norman French origin.Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 276. It became very popular in the English language after the Norman conquest of England in 1066,All Things William"Meaning & Origin of the Name"/ref> and remained so throughout the Middle Ages and into the modern era. It is sometimes abbreviated "Wm." Shortened familiar versions in English include Will, Wills, Willy, Willie, Liam, Bill, and Billy. A common Irish form is Liam. Scottish diminutives include Wull, Willie or Wullie (as in Oor Wullie or the play ''Douglas''). Female forms are Willa, Willemina, Wilma and Wilhelmina. Etymology William is related to the German given name ''Wilhelm''. Both ultimately descend from Proto-Germanic ''*Wiljahelmaz'', with a direct cognate also in the Old Norse name ''Vilhjalmr'' and a West Germanic borrowing into Medieval Latin ''Willelmus''. The Proto-Germ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Akinetic Mutism
Akinetic mutism is a medical term describing patients tending neither to move ( akinesia) nor speak (mutism). Akinetic mutism was first described in 1941 as a mental state where patients lack the ability to move or speak. However, their eyes may follow their observer or be diverted by sound. Patients lack most motor functions such as speech, facial expressions, and gestures, but demonstrate apparent alertness. They exhibit reduced activity and slowness, and can speak in whispered monosyllables. Patients often show visual fixation on their examiner, move their eyes in response to an auditory stimulus, or move after often repeated commands. Patients with akinetic mutism are not paralyzed, but lack the will to move. Many patients describe that as soon as they "will" or attempt a movement, a "counter-will" or "resistance" rises up to meet them. Types Akinetic mutism varies across all patients. Its form, intensity, and clinical features correspond more closely to its functiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waxy Flexibility
Waxy flexibility is a psychomotor symptom of catatonia as associated with schizophrenia, bipolar disorder, or other mental disorders which leads to a decreased response to stimuli and a tendency to remain in an immobile posture. Attempts to reposition the patient are met by "slight, even resistance", and after being repositioned, the patient will typically remain in the new position. Waxy flexibility rarely occurs in cases of delirium. The presence of waxy flexibility along with at least two other catatonic symptoms such as stupor or negativism are enough to warrant a diagnosis of catatonia. If one were to move the arm of someone with waxy flexibility, the patient would keep that arm where it had been positioned until moved again, as if positioning malleable wax. Further alteration of an individual's posture is similar to bending a candle. Although waxy flexibility has historically been linked to schizophrenia, there are also other disorders which it may be associated with, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catalepsy
Catalepsy (from Ancient Greek , , "seizing, grasping") is a nervous condition characterized by muscle, muscular rigidity and fixity of human position, posture regardless of external stimuli, as well as decreased sensitivity to pain. Signs and symptoms Symptoms include a rigid body, rigid limbs, limbs staying in same position when moved (waxy flexibility), no response, loss of muscle control, and slowing down of bodily functions, such as breathing. Causes Catalepsy is a symptom of certain nervous disorders or conditions such as Parkinson's disease and epilepsy. It is also a characteristic symptom of cocaine withdrawal, as well as one of the features of catatonia. It can be caused by schizophrenia treatment with anti-psychotics, such as haloperidol, and by the anesthetic ketamine. Protein kinase A has been suggested as a mediator of cataleptic behavior. Unsuggested waxy catalepsy, sometimes accompanied by spontaneous anesthesia, is seen as an indicator of hypnotic trance. Su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Project MKUltra
Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weaken individuals and force confessions through brainwashing and psychological torture. It began in 1953 and was halted in 1973. MKUltra used numerous methods to manipulate its subjects' mental states and brain functions, such as the covert administration of high doses of psychoactive drugs (especially LSD) and other chemicals, electroshocks,National Public Radio (NPR), 9 Sept. 2019"The CIA's Secret Quest For Mind Control: Torture, LSD And A 'Poisoner In Chief'"(On-air interview with journalist Stephen Kinzer) hypnosis, sensory deprivation, isolation, and verbal and sexual abuse, in addition to other forms of torture. MKUltra was preceded by two drug-related experiments, Project Bluebird and Project Artichoke. It was organized through ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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