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Buehler Test
The Buehler test is an ''in vivo'' test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon Buehler in 1965 and further explained in 1980. It is a non-adjuvant test. In the test, guinea pigs are exposed to a high dose of the substance. They are then given a challenge dose, which is the highest dose that does not cause irritation.{{cite web , author=OECD , authorlink=Organisation for Economic Co-operation and Development , title=Test No. 406: Skin Sensitisation , work=OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals (OECD TG) are a set of internationally accepted specifications for the testing of chemicals decided on by the Organisation for Economic Co-operation and Development (OECD). They were first published in ..., Section 4 , doi=10.1787/9789264070660-en , publisher=OECD Publishing , date=1992-07-17 , url=http://www.oecd-ilibrary.org/environment/test-no-406-skin-sensit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vivo
Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism. Examples of investigations ''in vivo'' include: the pathogenesis of disease by comparing the effects of bacterial infection with the effects of purified bacterial toxins; the development of non-antibiotics, antiviral drugs, and new drugs generally; and new surgical procedures. Consequently, animal testing and clinical trials are major elements of ''in vivo'' research. ''In vivo'' testing is often employed over ''in vitro'' because it is better suited for observing the overall effects of an experiment on a living subject. In drug discovery, for example, verification of efficacy ''in vivo'' is crucial, because ''in vitro'' assays can sometimes yield misleading results with drug c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergens
An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response. In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. Most humans mount significant immunoglobulin E responses only as a defense against parasitic infections. However, some individuals may respond to many common environmental antigens. This hereditary predisposition is called atopy. In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity. Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals. Examples Allergens can be found in a variety of sources, such as dust mite excretion, pollen, pet dander, or even royal jelly. Food allergies are not as com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Archives Of Dermatology
''JAMA Dermatology'' is a monthly peer-reviewed medical journal published by the American Medical Association. It covers the effectiveness of diagnosis and treatment in medical and surgical dermatology, pediatric and geriatric dermatology, and oncologic and aesthetic dermatologic surgery. The journal was established in the ''Archives of Dermatology and Syphilology'' (1920–1950), continuing as the ''A.M.A. Archives of Dermatology and Syphilology'' (1950–1954), then ''A.M.A. Archives of Dermatology'' (1955–1960), then ''Archives of Dermatology'' (1960–2012), obtaining its current name in January 2013. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 11.816, ranking it 2nd out of 69 journals in the category "Dermatology". The editor-in-chief is Kanade Shinkai (University of California, San Francisco). Abstracting and indexing The journal is abstracted and indexed in Index Medicus/MEDLINE/PubMed. See also *List of American Medical Associati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adjuvant
In pharmacology, an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs. Specifically, the term can refer to: * Adjuvant therapy in cancer management * Analgesic adjuvant in pain management * Immunologic adjuvant In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word , meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to acce ... in vaccines {{sia Adjuvants ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OECD Guidelines For The Testing Of Chemicals
OECD Guidelines for the Testing of Chemicals (OECD TG) are a set of internationally accepted specifications for the testing of chemicals decided on by the Organisation for Economic Co-operation and Development (OECD). They were first published in 1981. They are split into five sections: * Section 1: Physical Chemical Properties * Section 2: Effects on Biotic Systems * Section 3: Environmental Fate and Behaviour * Section 4: Health Effects * Section 5: Other Test Guidelines Guidelines are numbered with three digit numbers, the section number being the first number. Sometimes guidelines are suffixed with a letter. Guidelines are under constant review, with guidelines being periodically updated, new guidelines being adopted, and guidelines being withdrawn. Previous guidelines are maintained on the website for reference purposes. Animal welfare concerns are dealt with by ensuring that animal tests are only permitted where necessary. An OECD Directive obligates a national regulator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
