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Bryan L. Roth
Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine. He is recognized for his discoveries and inventions in the general areas of molecular pharmacology, GPCR structure, and function and synthetic neurobiology. He is a member of the American Academy of Arts and Sciences (AAAS) and the National Academy of Medicine (NAM). Education Roth earned his B.A. in biology from Carroll College in 1977 and his M.D. and Ph.D. in biochemistry from Saint Louis University in 1983. After postdoctoral training at the National Institute of Mental Health (NIMH), he completed a psychiatry residency and fellowship at Stanford University in 1991. The same year, he was appointed Assistant Professor in the Department of Psychiatry at Case Western Reserve University. In 2003 he became a Professor of Biochemistry at Case Western Reserve University School of Medicine with secondary appointments in Psychiatry, Oncology, and Ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CREDENTIAL
A credential is a piece of any document that details a qualification, competence, or authority issued to an individual by a third party with a relevant or ''de facto'' authority or assumed competence to do so. Examples of credentials include academic diplomas, academic degrees, Professional certification, certifications, security clearances, Identity document, identification documents, badges, passwords, user names, key (lock), keys, power of attorney, powers of attorney, and so on. Sometimes publications, such as scientific papers or books, may be viewed as similar to credentials by some people, especially if the publication was peer reviewed or made in a well-known Academic journal, journal or reputable publisher. Types and documentation of credentials A person holding a credential is usually given documentation or secret knowledge (''e.g.,'' a password or key) as proof of the credential. Sometimes this proof (or a copy of it) is held by a third, trusted party. While in some c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Activated Solely By A Synthetic Ligand
A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially engineered protein receptors used in the field of chemogenetics which are selectively activated by certain ligands. They are used in biomedical research, in particular in neuroscience to manipulate the activity of neurons. Originally differentiated by the approach used to engineer them, RASSLs and DREADDs are often used interchangeably now to represent an engineered receptor-ligand system. These systems typically utilize G protein-coupled receptors ( GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), and not to endogenous ligands. Several types of these receptors exists, derived from muscarinic or κ-opioid receptors. Types of RASSLs / DREADDs One of the first DREADDs was based on the human M3 muscarinic receptor (hM3). Only two point mutations of hM3 were required to achieve a m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of North Carolina Faculty
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the Midd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carroll College (Montana) Alumni
Carroll College is a private Catholic college in Helena, Montana. The college has 21 buildings on a 63-acre campus, has over 35 academic majors, participates in 15 NAIA athletic sports, and is home to All Saints Chapel. The college motto, in Latin, is ''“Non scholae, sed vitae.”'' The college translates this into English as “Not for school, but for life.” Carroll's colors are purple and gold and the school's athletics teams are known as the Fighting Saints. History In 1883, the first bishop of Helena, John Baptist Brondel, proposed a Catholic college in Montana to help produce future priests for the soon-to-be diocese of Helena. He died before his plans could be realized. Pope Pius X selected John Patrick Carroll, a young priest from Dubuque, Iowa, as Brondel's successor. Bishop John Patrick Carroll, second Bishop of the Diocese of Helena, was able to carve out the funding needed to launch the college while at the same time raising money to construct the Cathedral of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saint Louis University Alumni
In Christian belief, a saint is a person who is recognized as having an exceptional degree of holiness, likeness, or closeness to God. However, the use of the term ''saint'' depends on the context and denomination. In Anglican, Oriental Orthodox, and Lutheran doctrine, all of their faithful deceased in Heaven are considered to be saints, but a selected few are considered worthy of greater honor or emulation. Official ecclesiastical recognition, and veneration, is conferred on some denominational saints through the process of canonization in the Catholic Church or glorification in the Eastern Orthodox Church after their approval. In many Protestant denominations, and following from Pauline usage, ''saint'' refers broadly to any holy Christian, without special recognition or selection. While the English word ''saint'' (deriving from the Latin ) originated in Christianity, historians of religion tend to use the appellation "in a more general way to refer to the state of special ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Year Of Birth Missing (living People)
A year is a unit of time based on how long it takes the Earth to orbit the Sun. In scientific use, the tropical year (approximately 365 solar days, 5 hours, 48 minutes, 45 seconds) and the sidereal year (about 20 minutes longer) are more exact. The modern calendar year, as reckoned according to the Gregorian calendar, approximates the tropical year by using a system of leap years. The term 'year' is also used to indicate other periods of roughly similar duration, such as the lunar year (a roughly 354-day cycle of twelve of the Moon's phasessee lunar calendar), as well as periods loosely associated with the calendar or astronomical year, such as the seasonal year, the fiscal year, the academic year, etc. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by changes in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ultra-large-scale Docking
Ultra-large-scale docking, sometimes abbreviated as Ultra-LSD, is an ultra-large-scale approach to protein–ligand docking and virtual screening. It employs molecular docking campaigns against libraries of millions or billions of chemical compounds to discover new drugs. The virtual screening phase identifies potential high-affinity ligands and then selected promising compounds are synthesized and further evaluated in the laboratory, including in terms of properties like functional activity and selectivity. The purpose of Ultra-LSD is to discover novel chemical scaffolds for ligands of molecular targets. Ultra-LSD was developed by Brian Shoichet and John Irwin at the University of California, San Francisco, Bryan L. Roth at University of North Carolina at Chapel Hill, and other colleagues, and was first described in 2019. The researchers have conducted Ultra-LSD campaigns against a variety of targets, including the serotonin 5-HT2A receptor, the melatonin receptors, the dopami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society For Pharmacology And Experimental Therapeutics
The American Society for Pharmacology and Experimental Therapeutics (ASPET) is a scientific society founded in late 1908 by John Jacob Abel of Johns Hopkins University (also the founder of the American Society for Biochemistry and Molecular Biology), with the aim of promoting the growth of pharmacological research. Many society members are researchers in basic and clinical pharmacology who help develop disease-fighting medications and therapeutics. ASPET is one of the constituent societies of the Federation of American Societies for Experimental Biology (FASEB). The society's headquarters are in Rockville, MD. The current president is Michael F. Jarvis. Publications The society publishes three research journals and a review journal: the '' Journal of Pharmacology and Experimental Therapeutics'', '' Drug Metabolism and Disposition'', '' Molecular Pharmacology'', and ''Pharmacological Reviews'' Starting in 2012 these publications are only offered online. The society copublishes a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wired (magazine)
''Wired'' is a bi-monthly American magazine that focuses on how emerging technologies affect culture, the economy, and politics. It is published in both print and Online magazine, online editions by Condé Nast. The magazine has been in publication since its launch in January 1993. Its editorial office is based in San Francisco, California, with its business headquarters located in New York City. ''Wired'' quickly became recognized as the voice of the emerging digital economy and culture and a pace setter in print design and web design. From 1998 until 2006, the magazine and its website, ''Wired.com'', experienced separate ownership before being fully consolidated under Condé Nast in 2006. It has won multiple National Magazine Awards and has been credited with shaping discourse around the digital revolution. The magazine also coined the term Crowdsourcing, ''crowdsourcing'', as well as its annual tradition of handing out Vaporware Awards. ''Wired'' has launched several in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Chemical Biology
''Nature Chemical Biology'' is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was established in June 2005 by founding Chief Editor Terry L. Sheppard as part of Nature Publishing Group. Sheppard was the Chief Editor of the journal 2004–2022. The current editor-in-chief is Russell Johnson. Aims and scope The publishing focus of ''Nature Chemical Biology'' is a forum for original research and commentary in chemical biology. Published topics encompass concepts and research methods in chemistry, biology, and related disciplines with the result of controlling biological systems at the molecular level. Authors (contributors) are chemical biologists, also chemists involved in interdisciplinary research between chemistry and biology, along with biologists who produce research results in understanding and controlling biological processes at the molecular level. Interdisciplinary research in chemistry and biology is emphasized. The journal's main focus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Signaling
''Science Signaling'' is a peer-reviewed scientific journal that is focused on mechanisms of cell communication. It is published online weekly by the American Association for the Advancement of Science (AAAS). The editor-in-chief is John F. Foley, the Chief Scientific Advisor is Michael B. Yaffe (Massachusetts Institute of Technology), and the journal is part of thScience Family of Journalsof which Holden Thorp is the Editor-in-Chief. Scope The journal covers research on cell signaling and the processes of cellular regulation. In addition, the journal covers signaling networks, synthetic biology, systems biology, drug discovery, and computation and modeling of regulatory pathways. Besides full length articles, it also publishes reviews, focus articles, and editor-written highlights of select research papers. History The journal was established in 1999 as ''Science's STKE''. On January 8, 2008, it obtained its current name and volume numbering restarted at 1. As ''Science's S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
