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Brunfelsamidine
Brunfelsamidine is a poisonous pyrrolidine occurring in several species belonging to the Solanaceae, Solanaceous (nightshade family) genus ''Brunfelsia'', which has convulsant and neurotoxic effects. It is a fairly common cause of poisoning among domestic animals such as cows and dogs that eat the plant. Symptoms are similar to poisoning from strychnine and can last from a few hours up to several days. It is also a weak tryptase (type of serine protease) inhibitor and found in Leptonychia pubescens References Convulsants Plant toxins Alkaloids found in Solanaceae Amidines Pyrroles {{heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brunfelsia
''Brunfelsia'' is a genus of flowering plants belonging to subfamily Petunioideae of the nightshade family Solanaceae. The 50 or so species have been grouped into the three sections: ''Brunfelsia'' (circa 22 species), ''Franciscea'' (circa 18 species) and ''Guianenses'' (circa 6 species), which differ significantly in both distribution and characteristics, although molecular data have revealed that only two sections are natural (monophyletic), namely the Caribbean section ''Brunfelsia'' and a common section for all South American species.Filipowicz, N. and S. S. Renner. 2012''Brunfelsia'' (Solanaceae): A genus evenly divided between South America and radiations on Cuba and other Antillean Islands.''Molecular Phylogenetics and Evolution'' 64 1-11. Carl Linnaeus, Linnaeus named the genus for the early German herbalist Otto Brunfels (1488–1534). Common names for the genus include raintree, yesterday-today-tomorrow and lady of the night. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrrolidine
Pyrrolidine, also known as tetrahydropyrrole, is an organic compound with the molecular formula (CH2)4NH. It is a cyclic secondary amine, also classified as a saturated heterocycle. It is a colourless liquid that is miscible with water and most organic solvents. It has a characteristic odor that has been described as "ammoniacal, fishy, shellfish-like". In addition to pyrrolidine itself, many substituted pyrrolidines are known. Production and synthesis Industrial production Pyrrolidine is prepared industrially by the reaction of 1,4-butanediol and ammonia at a temperature of 165–200 °C and a pressure of 17–21 MPa in the presence of a cobalt- and nickel oxide catalyst, which is supported on alumina. : The reaction is carried out in the liquid phase in a continuous tube- or tube bundle reactor, which is operated in the cycle gas method. The catalyst is arranged as a fixed-bed and the conversion is carried out in the downflow mode. The product is obtained after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solanaceae
The Solanaceae , or nightshades, are a family of flowering plants that ranges from annual and perennial herbs to vines, lianas, epiphytes, shrubs, and trees, and includes a number of agricultural crops, medicinal plants, spices, weeds, and ornamentals. Many members of the family contain potent alkaloids, and some are highly toxic, but many—including tomatoes, potatoes, eggplant, bell and chili peppers—are used as food. The family belongs to the order Solanales, in the asterid group and class Magnoliopsida ( dicotyledons). The Solanaceae consists of about 98 genera and some 2,700 species, with a great diversity of habitats, morphology and ecology. The name Solanaceae derives from the genus '' Solanum''. The etymology of the Latin word is unclear. The name may come from a perceived resemblance of certain solanaceous flowers to the sun and its rays. At least one species of ''Solanum'' is known as the "sunberry". Alternatively, the name could originate from the Latin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convulsant
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent excitotoxicity. Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions as a side effect at high doses (e.g. bupropion, tramadol, pethidine, dextropropoxyphene, clomipramine) but only drugs whose primary action is to cause convulsions are known as convulsants. Nerve agents such as sarin, which were developed as chemical weapons, produce convulsions as a major part of their toxidrome, but also produce a number of other effects in the body and are usually classified separately. Dieldrin which was developed as an insecticide blocks chloride influx into the neurons causing hyperexcitability of the CNS and convulsions. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxic
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. This can eventually disrupt or even kill neurons, which are cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from organ transplants, radiation treatment, certain drug therapies, recreational drug use, and exposure to heavy metals, bites from certain species of venomous snakes, pesticides, certain industrial cleaning solvents, fuels and certain naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness, loss of memory, vision, and/o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahedron Letters
''Tetrahedron Letters'' is a weekly international journal for rapid publication of full original research papers in the field of organic chemistry. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 2.415. Indexing ''Tetrahedron Letters'' is indexed in: References See also *''Tetrahedron In geometry, a tetrahedron (plural: tetrahedra or tetrahedrons), also known as a triangular pyramid, is a polyhedron composed of four triangular faces, six straight edges, and four vertex corners. The tetrahedron is the simplest of all the ...'' *'' Tetrahedron: Asymmetry'' Chemistry journals Weekly journals Publications established in 1959 Elsevier academic journals {{chem-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia. While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant and performance-enhancing drug. The most common source is from the seeds of the '' Strychnos nux-vomica'' tree. Biosynthesis Strychnine is a terpene indole alkaloid belonging to the '' Strychnos'' family of ''Corynanthe'' alkaloids, and it is derived from tryptamine and secologanin. The biosynthesis of strychine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by a Pictet-Spengler reaction to form strict ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leptonychia Pubescens
''Leptonychia'' is a genus of flowering plants belonging to the family Malvaceae. Its native range is Tropical Africa, Indo-China to New Guinea. Species: *''Leptonychia adolfi-friederici'' *'' Leptonychia bampsii'' *''Leptonychia banahaensis'' *''Leptonychia batangensis'' *''Leptonychia brieyi'' *'' Leptonychia caudata'' *'' Leptonychia chrysocarpa'' *''Leptonychia densivenia'' *'' Leptonychia devillei'' *'' Leptonychia dewildei'' *''Leptonychia echinocarpa'' *'' Leptonychia kamerunensis'' *'' Leptonychia lanceolata'' *''Leptonychia lasiogyne'' *''Leptonychia ledermannii'' *''Leptonychia lokundjensis'' *''Leptonychia longicuspidata'' *''Leptonychia macrantha'' *''Leptonychia mayumbensis'' *''Leptonychia melanocarpa'' *''Leptonychia mildbraedii'' *''Leptonychia molundensis'' *''Leptonychia moyesiae'' *''Leptonychia multiflora'' *''Leptonychia occidentalis'' *''Leptonychia pallida'' *'' Leptonychia pallidiflora'' *''Leptonychia parviflora'' *'' Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Planta Medica
''Planta Medica'' is a peer-reviewed journal published by Thieme Medical Publishers and covers medicinal plants and bioactive natural products of natural origin. ''Planta Medica'' is the official journal of the Society for Medicinal Plant and Natural Product Research (GA). According to the ''Journal Citation Reports'', the journal's 2016 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... is 2.342. Planta Medica is a Q1 journal in integrative and complementary medicine, and a Q2 journal in plant sciences. Oliver Kayser, from the TU Dortmund University, and Robert Fuerst, Wolfgang-von-Goethe University Frankfurt are the editors-in-chief. In the 18 issues published per year, Planta Medica covers the following areas of medicinal plants and natural product research: * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convulsants
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent excitotoxicity. Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions as a side effect at high doses (e.g. bupropion, tramadol, pethidine, dextropropoxyphene, clomipramine) but only drugs whose primary action is to cause convulsions are known as convulsants. Nerve agents such as sarin, which were developed as chemical weapons, produce convulsions as a major part of their toxidrome, but also produce a number of other effects in the body and are usually classified separately. Dieldrin which was developed as an insecticide blocks chloride influx into the neurons causing hyperexcitability of the CNS and convulsi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Toxins
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Less ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids Found In Solanaceae
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , |
