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Brockham Park
Brockham is a village and civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, with the River Mole flowing west through the village. At the time of the 2021 census, it had a population of 2,198 .Key Statistics; Quick Statistics: Population Density '''' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mole Valley
Mole Valley is a local government district in Surrey, England. Its council is based in Dorking, and the district's other town is Leatherhead. The largest villages are Ashtead, Fetcham and Great Bookham, in the northern third of the district. Most of the district is on the escarpments of or adjoins the Surrey Hills, a designated Area of Outstanding Natural Beauty, which cover parts of the North Downs and Greensand Ridge, including locally Leith Hill, Polesden Lacey and Box Hill. Denbies Wine Estate, the largest vineyard in the country, is on the hills north-west of Dorking. The Pilgrims' Way footpath runs along the North Downs. There are stations on the London–Worthing and Reading–Gatwick Airport railways, and in the northern third, a commuter stopping-service pattern line, London–Guildford (via Epsom) line. The A24 road and the M25 motorway are the main thoroughfares and relative to London the incidence of car ownership is high. Between 2011 and its final iteratio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chancellor Of The Exchequer
The chancellor of the exchequer, often abbreviated to chancellor, is a senior minister of the Crown within the Government of the United Kingdom, and the head of HM Treasury, His Majesty's Treasury. As one of the four Great Offices of State, the chancellor is a high-ranking member of the British Cabinet. Responsible for all economic and financial matters, the role is equivalent to that of a finance minister in other countries. The chancellor is now always second lord of the Treasury as one of at least six Lords Commissioners of the Treasury, lords commissioners of the Treasury, responsible for executing the office of the Treasurer of the Exchequer the others are the prime minister and Commons government whips. In the 18th and early 19th centuries, it was common for the prime minister also to serve as Chancellor of the Exchequer if he sat in the Commons; the last Chancellor who was simultaneously prime minister and Chancellor of the Exchequer was Stanley Baldwin in 1923. Formerl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surrey County Council
Surrey County Council is the county council for the non-metropolitan county of Surrey, England. The council is composed of 81 elected councillors, and in all but one election since 1974 the Conservative Party has held the majority. The leader of the council is Tim Oliver. History Elected county councils were created in 1889 under the Local Government Act 1888, taking over many administrative functions which had been performed by unelected magistrates at the quarter sessions. In Surrey's case, most such functions in the north-east of the county had already passed to the Metropolitan Board of Works, which had been established in 1856 to administer the urban area of London. Under the 1888 Act, the Metropolitan Board of Works' area became the new County of London. The then borough of Croydon lay outside the County of London, but was considered large enough to run county-level services and so it was made a county borough. Surrey County Council was elected by and provided services t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRSA
Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is a group of gram-positive bacteria that are genetically distinct from other strains of ''Staphylococcus aureus''. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths worldwide attributable to antimicrobial resistance in 2019. MRSA is any strain of ''S. aureus'' that has developed (through mutation) or acquired (through horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some penams (penicillin derivatives such as methicillin and oxacillin) and cephems such as the cephalosporins. Strains unable to resist these antibiotics are classified as methicillin-susceptible ''S. aureus'', or MSSA. MRSA infection is common in hospitals, prisons, and nursing homes, where people with open wounds, invasive devices such as catheters, and weakened immune systems are at greate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methicillin
Methicillin ( USAN), also known as meticillin ( INN), is a narrow-spectrum β-lactam antibiotic of the penicillin class. Methicillin was discovered in 1960. Medical uses Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, selection of methicillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for any more. It also served a purpose in the laboratory to determine the antibiotic sensitivity of ''Staphylococcus aureus'' to other penicillins facing β-lactam resistance; this role has now been passed on to other penicillins, namely '' cloxacillin'', as well as genetic testing for the presence of '' mecA'' gene by '' PCR''. Spectrum of activity At one time, methicillin was u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. rubens''. Most penicillins in clinical use are synthesised by ''Penicillium chrysogenum, P. chrysogenum'' using industrial fermentation, deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: benzylpenicillin, penicillin G (intramuscular injection, intramuscular or Intravenous therapy, intravenous use) and phenoxymethylpenicillin, penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococcus, staphylococci and streptococcus, streptococci. They are still widely used today for various bacterial infections, though many types of bacteria have developed antibiotic res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
6-APA
6-APA ((+)-6-aminopenicillanic acid) is an organic compound that is used in the synthesis of β–lactam antibiotics including amoxicillin, ampicillin, oxacillin, and carbenicillin. The major commercial source of 6-APA is natural penicillin G, which contains an N-phenylacetyl substituent. The semi-synthetic penicillins derived from 6-APA are also referred to as penicillins and are considered part of the penicillin family of antibiotics. History In 1958, Beecham scientists from Brockham Park, Surrey, found a way to obtain 6-APA from penicillin. Other β-lactam antibiotics could then be synthesized by attaching various side-chains to the nucleus.F.P. Doyle, J.H.C. Nayler, G.N. Rolinson ''US Patent 2,941,995'', filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid. The reason why this was achieved so many years after the commercial development of penicillin by Howard Florey and Ernst Chain lies in the fact that penicillin itself is very suscepti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brockham Park
Brockham is a village and civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, with the River Mole flowing west through the village. At the time of the 2021 census, it had a population of 2,198 .Key Statistics; Quick Statistics: Population Density '''' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GlaxoSmithKline
GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British Multinational corporation, multinational Pharmaceutics, pharmaceutical and biotechnology company with headquarters in London. It was established in 2000 by a Mergers and acquisitions, merger of Glaxo Wellcome and SmithKline Beecham, which was itself a merger of a number of pharmaceutical companies around the Smith, Kline & French firm. GSK is the tenth largest pharmaceutical company and No. 294 on the 2022 Fortune Global 500, ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm (company), Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck & Co., Merck Sharp & Dohme. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. As of February 2024, it had a Market capitalization, market capitalisation of £69 billion, the eighth largest on the London Stock Exchange. The company developed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beecham Group
The Beecham Group plc was a British pharmaceutical company. It was once a constituent of the FTSE 100 Index. Founded by Thomas Beecham who opened the first factory in St Helens, Lancashire in 1859, Beecham focused on marketing the business by advertising in newspapers and using a network of wholesale agents in northern England and in London, rapidly building up the business. In August 1859 he created the slogan for Beecham's Pills: "Worth a guinea a box", considered to be the world's first advertising slogan, which helped the business become a global brand. Beecham, after having merged with American pharmaceutical company SmithKline Beckman to become SmithKline Beecham, merged with Glaxo Wellcome to become GlaxoSmithKline (GSK). GSK (and later, Haleon) still uses the Beechams brand name in the UK for its over-the-counter cold and flu relief products. Early history Beecham began as the family business of Thomas Beecham (1820–1907). (Beecham would become the grandfathe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chalk
Chalk is a soft, white, porous, sedimentary carbonate rock. It is a form of limestone composed of the mineral calcite and originally formed deep under the sea by the compression of microscopic plankton that had settled to the sea floor. Chalk is common throughout Western Europe, where deposits underlie parts of France, and steep cliffs are often seen where they meet the sea in places such as the Dover cliffs on the Kent coast of the English Channel. Chalk is mined for use in industry, such as for quicklime, bricks and builder's putty, and in agriculture, for raising pH in soils with high acidity. It is also used for " blackboard chalk" for writing and drawing on various types of surfaces, although these can also be manufactured from other carbonate-based minerals, or gypsum. Description Chalk is a fine-textured, earthy type of limestone distinguished by its light colour, softness, and high porosity. It is composed mostly of tiny fragments of the calcite shells or sk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guy Fawkes Night
Guy Fawkes Night, also known as Guy Fawkes Day, Bonfire Night and Fireworks Night, is an annual commemoration list of minor secular observances#November, observed on 5 November, primarily in Great Britain, involving bonfires and fireworks displays. Its history begins with the events of 5 November 1605 Old Style and New Style dates, O.S., when Guy Fawkes, a member of the Gunpowder Plot, was arrested while guarding explosives the plotters had placed beneath the House of Lords. The Catholic Church in England and Wales, Catholic plotters had intended to assassinate English Reformation, Protestant king James VI and I, James I and his parliament. Celebrating that the king had survived, people lit bonfires around London. Months later, the Observance of 5th November Act 1605, Observance of 5th November Act mandated an annual public day of thanksgiving for the plot's failure. Within a few decades Gunpowder Treason Day, as it was known, became the predominant English state co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
