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Brain Aminopeptidase A Inhibitor
Aminopeptidase A inhibitors are a class of antihypertensive drugs that work by inhibiting the conversion of angiotensin II to angiotensin III by the aminopeptidase A enzyme. The first medication in this class is firibastat Firibastat is a prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a .... It is hypothesized that the drugs may be more effective in overweight people and those of African descent. References Antihypertensive agents {{antihypertensive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiotensin II
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys. An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named "angiotonin" or "hypertensin", later renamed "angiotensin" as a consensus by the 2 groups that independently discovered it) and subsequently characterized and synthesized by groups at the Cleveland Clinic and Ciba laboratories. Precursor and types Angiotensinogen Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as having many other roles not related to angiotensin peptides. It is a me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiotensin III
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys. An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named "angiotonin" or "hypertensin", later renamed "angiotensin" as a consensus by the 2 groups that independently discovered it) and subsequently characterized and synthesized by groups at the Cleveland Clinic and Ciba laboratories. Precursor and types Angiotensinogen Angiotensinogen is an α-2-globulin synthesized in the liver and is a precursor for angiotensin, but has also been indicated as having many other roles not related to angiotensin peptides. It is a member ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopeptidase A
Glutamyl aminopeptidase (, ''aminopeptidase A'', ''aspartate aminopeptidase'', ''angiotensinase A'', ''glutamyl peptidase'', ''Ca2+-activated glutamate aminopeptidase'', ''membrane aminopeptidase II'', ''antigen BP-1/6C3 of mouse B lymphocytes'', ''L-aspartate aminopeptidase'', ''angiotensinase A2'') is an enzyme encoded by the gene. Glutamyl aminopeptidase has also recently been designated CD249 (cluster of differentiation 249). Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure. References External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Firibastat
Firibastat is a prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ... of two brain aminopeptidase A inhibitors, developed to treat resistant hypertension. It failed to show efficacy in a Phase III trial. References {{reflist Prodrugs Antihypertensive agents Sulfonic acids Diamines Organic disulfides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
