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Bovine Respiratory Disease
Bovine respiratory disease (BRD) is the most common and economically devastating infectious disease affecting beef cattle in the world. It is a complex, bacterial or viral infection that causes pneumonia in calves which can be fatal. It also affects many other species of feedlot animals like sheep and pigs, but is most prominent in calves. The infection is usually a sum of three codependent factors: stress, an underlying viral infection, and a new bacterial infection. The diagnosis of the disease is complex since there are multiple possible causes and cattle are reluctant to display any indications of pain. The disease manifests itself most often in calves within four weeks of weaning, when calves are sorted into groups of roughly 10–15 in number, and sold to different feedlots via train, tractor trailer, and truck. Because of this, BRD is most commonly referred to as "shipping fever". It is not known whether the stress itself, co-mingling, or travel conditions are at most to b ...
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Infectious Disease
An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an Disease#Terminology, illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently pathogenic bacteria, bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an Innate immune system, innate response, often involving inflammation, followed by an Adaptive immune system, adaptive response. Treatment for infections depends on the type of pathogen involved. Common medications include: * Antibiotics for bacterial infections. * Antivirals for viral infections. * Antifungals for fungal infections. * Antiprotozoals for protozoan infections. * Antihelminthics for infections caused by parasi ...
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Beef Cattle
Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk (production)). The meat of mature or almost mature cattle is mostly known as beef. In beef production there are three main stages: cow-calf operations, backgrounding, and feedlot operations. The production cycle of the animals starts at cow-calf operations; this operation is designed specifically to breed cows for their offspring. From here the calves are backgrounded for a feedlot. Animals grown specifically for the feedlot are known as feeder cattle, the goal of these animals is fattening. Animals not grown for a feedlot are typically female and are commonly known as replacement Cattle, heifers. While the principal use of beef cattle is meat production, other uses include leather, and beef by-products used in candy, shampoo, cosmetics, and insulin. Calving and breeding Besides breeding to meet the demand for beef production, owners also use selective breeding to attain specific ...
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Bacterial
Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal an ...
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Viral Infection
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells. Examples include the common cold, gastroenteritis, COVID-19, the flu, and rabies. Structural characteristics Basic structural characteristics, such as genome type, virion shape and replication site, generally share the same features among virus species within the same family. * Double-stranded DNA families: three are non-enveloped (''Adenoviridae'', ''Papillomaviridae'' and ''Polyomaviridae'') and two are enveloped (''Herpesviridae'' and ''Poxviridae''). All of the non-enveloped families have icosahedral capsids. * Partly double-stranded DNA viruses: ''Hepadnaviridae''. These viruses are enveloped. * One family of single-stranded DNA viruses infects humans: ''Parvoviridae''. These viruses are non-enveloped. * Positive single-stranded RNA families: three non-enveloped (''Astroviridae'', ''Calicivirid ...
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Pneumonia
Pneumonia is an Inflammation, inflammatory condition of the lung primarily affecting the small air sacs known as Pulmonary alveolus, alveoli. Symptoms typically include some combination of Cough#Classification, productive or dry cough, chest pain, fever, and Shortness of breath, difficulty breathing. The severity of the condition is variable. Pneumonia is usually caused by infection with viruses or bacteria, and less commonly by other microorganisms. Identifying the responsible pathogen can be difficult. Diagnosis is often based on symptoms and physical examination. Chest X-rays, blood tests, and Microbiological culture, culture of the sputum may help confirm the diagnosis. The disease may be classified by where it was acquired, such as community- or hospital-acquired or healthcare-associated pneumonia. Risk factors for pneumonia include cystic fibrosis, chronic obstructive pulmonary disease (COPD), sickle cell disease, asthma, diabetes, heart failure, a history of smoking, ...
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Calf (animal)
A calf (: calves) is a young domestic cow or bull. Calves are reared to become adult cattle or are slaughtered for their meat, called veal, and their Calfskin, hide. Terminology "Calf" is the term used from birth to weaning, when it becomes known as a ''weaner'' or ''weaner calf'', though in some areas the term "calf" may be used until the animal is a wiktionary:yearling, yearling. The birth of a calf is known as ''calving''. A calf that has lost its mother is an orphan calf, also known as a ''poddy'' or ''poddy-calf'' in British. ''Bobby calves'' are young calves which are to be slaughtered for human consumption. A ''vealer'' is a calf weighing less than about which is at about eight to nine months of age. A young female calf from birth until she has had a calf of her own is called a ''heifer'' (). In the American Old West, a motherless or small, runty calf was sometimes referred to as a dodie. Early development Calves may be produced by natural means, or by artificial ...
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Weaning
Weaning is the process of gradually introducing an infant human or other mammal to what will be its adult diet while withdrawing the supply of its mother's milk. In the United Kingdom, UK, weaning primarily refers to the introduction of solid foods at 6 months; in the United States, US, it primarily refers to stopping breastfeeding. The process takes place only in mammals, as only mammals produce milk. The infant is considered to be fully weaned once it is no longer breastfeeding, fed by any breast milk (or bottled Infant formula, substitute). Humans In some cultures, weaning progresses with the introduction of feeding the child food that has been prechewed by the parent along with continued breastfeeding, a practice known as premastication. The practice was important throughout human history in that it naturally gave a child a greatly improved protein source in addition to preventing iron deficiency. However, premasticated food from caregivers of lower socioeconomic status i ...
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Bovine Respiratory Syncytial Virus
Bovine respiratory syncytial virus (BRSV) is pneumovirus closely related to human respiratory syncytial virus (RSV) that is a common cause of respiratory disease in cattle, particularly calves. It is a negative-sense, single-stranded RNA virus that replicates in the cytoplasm of the cell. Similarly to other single-stranded RNA viruses, the genome of BRSV has a high mutation rate, which results in great antigenetic variation. Thus, BRSV can be split into four different subgroups based on antigen expression (A, B, AB, and intermediate). Causes In around 90% of cases, infection with BRSV results in secondary bacterial pneumonia due to interference with the host's immune system and enhancement of bacterial adherence and colonisation by the virus. ''Pasteurella multocida'', a common commensal of the nasopharynx of cattle, appears to be the main bacterial agent in BRSV-related bovine respiratory disease (BRD). Treatment Similarly to other viral infections, treatment of BRSV is ...
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Bovine Viral Diarrhea
Bovine viral diarrhea (BVD), bovine viral diarrhoea (UK English) or mucosal disease, previously referred to as bovine virus diarrhea (BVD), is an economically significant disease of cattle Cattle (''Bos taurus'') are large, domesticated, bovid ungulates widely kept as livestock. They are prominent modern members of the subfamily Bovinae and the most widespread species of the genus '' Bos''. Mature female cattle are calle ... that is found in the majority of countries throughout the world. Worldwide reviews of the economically assessed production losses and intervention programs (e.g. eradication programs, vaccination strategies and biosecurity measures) incurred by BVD infection have been published. The causative agent, bovine viral diarrhea virus (BVDV), is a member of the genus '' Pestivirus'' of the family Flaviviridae. BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects, as well as having a direct effect on respirato ...
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Infectious Bovine Rhinotracheitis
Bovine alphaherpesvirus 1 (BoHV-1) is a virus of the family ''Herpesviridae'' and the subfamily ''Alphaherpesvirinae'', known to cause several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. BoHV-1 is also a contributing factor in shipping fever, also known as bovine respiratory disease (BRD). It is spread horizontally through sexual contact, artificial insemination, and aerosol transmission and it may also be transmitted vertically across the placenta. BoHV-1 can cause both clinical and subclinical infections, depending on the virulence of the strain. Although these symptoms are mainly non-life-threatening it is an economically important disease as infection may cause a drop in production and affect trade restrictions. Like other herpesviruses, BoHV-1 causes a lifelong latent infection and sporadic shedding of the virus. The sciatic nerve and trigeminal nerve are the sites of latency. A reactivat ...
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Mannheimia Haemolytica
''Mannheimia haemolytica'' is a species of Gram-negative bacteria belonging to the family Pasteurellaceae. It is a facultatively anaerobic, non-spore-forming, and non-motile coccobacillus. ''M. haemolytica'' is a primary bacterial pathogen implicated in the bovine respiratory disease complex (BRDC), also commonly known as "shipping fever," particularly affecting cattle, sheep, and goats. History ''Mannheimia haemolytica'' was originally described as ''Pasteurella haemolytica'' by Newsom and Cross in 1932, based on bipolar organisms isolated from cases of pneumonia in sheep and cattle. For decades, it was classified within the genus ''Pasteurella''. However, advances in molecular taxonomy led to a reassessment of the '' asteurellahaemolytica'' complex. In 1999, Angen and colleagues conducted a comprehensive study using DNA–DNA hybridization and 16S rRNA gene sequencing, which demonstrated sufficient genetic divergence to warrant creation of a new genus, ''Mannheimia''. Pathogen ...
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Pasteurella Multocida
''Pasteurella multocida'' is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Strains of the species are currently classified into five serogroups (A, B, D, E, F) based on capsular composition and 16 somatic serovars (1–16). ''P. multocida'' is the cause of a range of diseases in mammals and birds, including fowl cholera in poultry, atrophic rhinitis in pigs, and bovine hemorrhagic septicemia in cattle and buffalo. It can also cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets. Many mammals (including domestic cats and dogs) and birds harbor it as part of their normal respiratory microbiota. History ''Pasteurella multocida'' was first found in 1878 in cholera-infected birds. However, it was not isolated until 1880, by Louis Pasteur, in whose honor ''Pasteurella'' is named. Disease :''See: Pasteurellosis'' ''P. multocida'' causes a range of diseases in wild and domesticated ...
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