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Biomesh
Biomesh (or biologic mesh) is a type of surgical mesh made from an organic biomaterial (such as porcine dermis, porcine Submucosa#Small intestinal submucosa, small intestine submucosa, bovine dermis or pericardium, and the dermis or fascia lata of a cadaveric human). Biologic mesh is primarily indicated for several types of hernia repair, including Inguinal hernia, inguinal and Incisional hernia, ventral hernias, hernia prophylaxis, and contaminated hernia repairs. However, it has also been used in pelvic floor dysfunction, parotidectomy, and Plastic surgery, reconstructive plastic surgery. The development of biologic mesh largely has derived from the need of a Biocompatibility, biocompatible material that addresses "the problems associated with a permanent synthetic mesh, including chronic inflammation, foreign body reaction, fibrosis, and mesh infection." , however, the efficacy and optimal use of biological mesh products remains in question. Development, benefits, and drawbacks ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surgical Mesh
Surgical mesh (also called hernia mash) is a medical implant made of loosely woven mesh, which is used in surgery as either a permanent or temporary structural support for organs and other tissues. Surgical mesh can be made from both inorganic and biological materials and is used in a variety of surgeries, although hernia repair is the most common application. It can also be used for reconstructive work, such as in pelvic organ prolapse or to repair physical defects (mainly of body cavity walls) created by extensive resections or traumatic tissue loss. Permanent meshes remain in the body, whereas temporary ones dissolve over time. One temporary mesh was shown in 2012 to fully dissolve after three years in a scientific trial on sheep. Some types of mesh combine permanent and temporary meshes which includes both resorbable vicryl, made from polyglycolic acid, and prolene, a non-resorbable polypropylene. Data of mechanical and biological behaviors of mesh ''in vivo'' may no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inguinal Hernia
An inguinal hernia or groin hernia is a hernia (protrusion) of abdominal cavity contents through the inguinal canal. Symptoms, which may include pain or discomfort especially with or following coughing, exercise, or bowel movements, are absent in about a third of patients. Symptoms often get worse throughout the day and improve when lying down. A bulging area may occur that becomes larger when bearing down. Inguinal hernias occur more often on the right than the left side. The main concern is strangulation, where the blood supply to part of the intestine is blocked. This usually produces severe pain and tenderness of the area. Risk factors for the development of a hernia include: smoking, chronic obstructive pulmonary disease, obesity, pregnancy, peritoneal dialysis, collagen vascular disease, and previous open appendectomy, among others. Predisposition to hernias is genetic and they occur more often in certain families. Deleterious mutations causing predisposition to he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Submucosa
The submucosa (or tela submucosa) is a thin layer of tissue in various organs of the gastrointestinal, respiratory, and genitourinary tracts. It is the layer of dense irregular connective tissue that supports the mucosa (mucous membrane) and joins it to the muscular layer, the bulk of overlying smooth muscle (fibers running circularly within layer of longitudinal muscle). The submucosa ('' sub-'' + ''mucosa'') is to a mucous membrane what the subserosa ('' sub-'' + ''serosa'') is to a serous membrane. Structure Blood vessels, lymphatic vessels, and nerves (all supplying the mucosa) will run through here. In the intestinal wall, tiny parasympathetic ganglia are scattered around forming the submucous plexus (or "Meissner's plexus") where preganglionic parasympathetic neurons synapse with postganglionic nerve fibers that supply the muscularis mucosae. Histologically, the wall of the alimentary canal shows four distinct layers (from the lumen moving out): mucosa, submuc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Random Clinical Trial
In common usage, randomness is the apparent or actual lack of definite pattern or predictability in information. A random sequence of events, symbols or steps often has no order and does not follow an intelligible pattern or combination. Individual random events are, by definition, unpredictable, but if there is a known probability distribution, the frequency of different outcomes over repeated events (or "trials") is predictable.Strictly speaking, the frequency of an outcome will converge almost surely to a predictable value as the number of trials becomes arbitrarily large. Non-convergence or convergence to a different value is possible, but has probability zero. Consistent non-convergence is thus evidence of the lack of a fixed probability distribution, as in many evolutionary processes. For example, when throwing two dice, the outcome of any particular roll is unpredictable, but a sum of 7 will tend to occur twice as often as 4. In this view, randomness is not haphazardne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadian Agency For Drugs And Technologies In Health
Canada's Drug Agency (CDA; ) is a pan-Canadian health organization responsible for coordinating and aligning drug policy across provinces and territories. The CDA provides Canada's various healthcare organizations with evidence-based advice, allowing them to make informed choices about drug, health technology, and health system policies, in collaboration with international partners. Its role differs from that of Health Canada in that it can provide data on the comparative effectiveness of drugs and make recommendations that factor in metrics beyond safety and quality, including cost effectiveness. History In Canada, healthcare falls under the jurisdiction of provinces and territories. As such, historically each province has managed their own pharmaceutical system, from formularies to public prescription drug programs, in different ways. This meant that health technology assessments were performed independently by a patchwork of organizations, with some provinces, like Quebec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biocompatibility
Biocompatibility is related to the behavior of biomaterials in various contexts. The term refers to the ability of a material to perform with an appropriate host response in a specific situation. The ambiguity of the term reflects the ongoing development of insights into how biomaterials interact with the human body and eventually how those interactions determine the clinical success of a medical device (such as pacemaker, hip replacement or stent). Modern medical devices and prostheses are often made of more than one material so it might not always be sufficient to talk about the biocompatibility of a specific material. Since the immune response and repair functions in the body are so complicated it is not adequate to describe the biocompatibility of a single material in relation to a single cell type or tissue. Sometimes one hears of biocompatibility testing that is a large battery of in vitro test that is used in accordance with ISO 10993 (or other similar standards) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parotidectomy
A parotidectomy is the surgical excision (removal) of the parotid gland, the major and largest of the salivary glands. The procedure is most typically performed due to neoplasms (tumors), which are growths of rapidly and abnormally dividing cells. Neoplasms can be benign (non-cancerous) or malignant (cancerous). The majority of parotid gland tumors are benign, however 20% of parotid tumors are found to be malignant. Parotidectomy is performed mostly by oral and maxillofacial surgeon and ENT surgeon. Anatomy There are two parotid glands in the human body. Each parotid gland is located high in the neck just below the ears. A salivary duct by which saliva is secreted (produced and released), runs through the inside of each cheek from each gland. Furthermore, the extratemporal (outside temporal bone) facial nerve and its subsidiaries run through the parotid gland and innervate (supply nerves to) the face. This nerve articulates the muscles for facial expression as well as mor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pelvic Floor Dysfunction
Pelvic floor dysfunction is a term used for a variety of disorders that occur when pelvic floor muscles and ligaments are impaired. The condition affects up to 50 percent of women who have given birth. Although this condition predominantly affects women, up to 16 percent of men are affected as well. Symptoms can include pelvic pain, pressure, pain during sex, urinary incontinence (UI), overactive bladder, bowel incontinence, incomplete emptying of feces, constipation, myofascial pelvic pain and pelvic organ prolapse. When pelvic organ prolapse occurs, there may be visible organ protrusion or a lump felt in the vagina or anus. Research carried out in the UK has shown that symptoms can restrict everyday life for women. However, many people found it difficult to talk about it and to seek care, as they experienced embarrassment and stigma. Common treatments for pelvic floor dysfunction are surgery, medication, physical therapy and lifestyle modifications. The term "pelvic floor dys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hernia
A hernia (: hernias or herniae, from Latin, meaning 'rupture') is the abnormal exit of tissue or an organ (anatomy), organ, such as the bowel, through the wall of the cavity in which it normally resides. The term is also used for the normal Development of the digestive system, development of the intestinal tract, referring to the retraction of the intestine from the extra-embryonal navel coelom into the abdomen in the healthy embryo at about 7 weeks. Various types of hernias can occur, most commonly involving the abdomen, and specifically the groin. Groin hernias are most commonly inguinal hernia, inguinal hernias but may also be femoral hernias. Other types of hernias include Hiatal hernia, hiatus, incisional hernia, incisional, and umbilical hernias. Symptoms are present in about 66% of people with groin hernias. This may include pain or discomfort in the lower abdomen, especially with coughing, exercise, or Urination, urinating or Defecation, defecating. Often, it gets worse th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Incisional Hernia
An incisional hernia is a type of hernia caused by an incompletely-healed surgical wound. Since median incisions in the abdomen are frequent for abdominal exploratory surgery, ventral incisional hernias are often also classified as ventral hernias due to their location. Not all ventral hernias are from incisions, as some may be caused by other trauma or congenital problems. Signs and symptoms Clinically, incisional hernias present as a bulge or protrusion at or near the area of a surgical incision. Virtually any prior abdominal operation can develop an incisional hernia at the scar area (provided adequate healing does not occur due to infection), including large abdominal procedures such as intestinal or vascular surgery, and small incisions, such as appendix removal or abdominal exploratory surgery. While incisional hernias can occur at any incision, they tend to occur more commonly along a straight line from the xiphoid process of the sternum straight down to the pubis, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
