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Bio E COVID-19
Corbevax is a protein subunit COVID-19 vaccine developed by Texas Children's Hospital Center for Vaccine Development and Baylor College of Medicine in Houston, Texas and Dynavax technologies based in Emeryville, California. It is licensed to Indian biopharmaceutical firm Biological E. Limited (BioE) for development and production. Technology The vaccine consists of a version of the receptor binding domain (RBD) of the SARS‑CoV‑2 spike protein, together with the adjuvants aluminium hydroxide gel and CpG 1018. The protein is produced by the yeast ''Pichia pastoris''; the process is similar to that of existing Hepatitis B vaccines. Manufacturing In April 2021, the U.S. International Development Finance Corporation (DFC) announced that it would fund the expansion of Biological E's manufacturing capabilities, so that it could produce at least 1 billion doses by the end of 2022. History Clinical trials A phase I clinical trial was carried out to evaluate the safety and i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a provisional name, 2019 novel coronavirus (2019-nCoV), and has also been called the human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization declared the outbreak a public health emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is contagious in humans. SARS‑CoV‑2 is a virus of the species '' severe acute respiratory syndrome–related coronavirus'' (SARSr-CoV), related to the SARS-CoV-1 virus that caused the 2002–2004 SARS outbreak. Despite its close relation to SARS-CoV-1, its closest known relatives, with which it forms a sister group, are the derived ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CpG Oligodeoxynucleotide
CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) backbone instead. When these CpG motifs are unmethylated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns ( PAMPs) due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor ( PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher primates. History Since 1893, it has been recognized that Coley's toxin, a mixture of bacterial cell lysate, has immunostimulatory properties that could reduce the progression of some carcino ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science And Technology In India
After independence, Jawaharlal Nehru, the first prime minister of India, initiated reforms to promote higher education and science and technology in India. The Indian Institute of Technology (IIT)—conceived by a 22-member committee of scholars and entrepreneurs in order to promote technical education—was inaugurated on 18 August 1951 at Kharagpur in West Bengal by the minister of education Maulana Abul Kalam Azad. More IITs were soon opened in Bombay, Madras, Kanpur and Delhi as well in the late 1950s and early 1960s along with the regional RECs (now National Institutes of Technology (NIT). Beginning in the 1960s, close ties with the Soviet Union enabled the Indian Space Research Organisation to rapidly develop the Indian space program and advance nuclear power in India even after the first nuclear test explosion by India on 18 May 1974 at Pokhran. India accounts for about 10% of all expenditure on research and development in Asia and the number of scientific publicat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indian COVID-19 Vaccines
Indian or Indians may refer to: Peoples South Asia * Indian people, people of Indian nationality, or people who have an Indian ancestor ** Non-resident Indian, a citizen of India who has temporarily emigrated to another country * South Asian ethnic groups, referring to people of the Indian subcontinent, as well as the greater South Asia region prior to the 1947 partition of India * Anglo-Indians, people with mixed Indian and British ancestry, or people of British descent born or living in the Indian subcontinent * East Indians, a Christian community in India Europe * British Indians, British people of Indian origin The Americas * Indo-Canadians, Canadian people of Indian origin * Indian Americans, American people of Indian origin * Indigenous peoples of the Americas, the pre-Columbian inhabitants of the Americas and their descendants ** Plains Indians, the common name for the Native Americans who lived on the Great Plains of North America ** Native Americans in the Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trials
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Outlook (Indian Magazine)
''Outlook'' is a weekly general interest English and Hindi news magazine published in India. History and profile ''Outlook'' was first issued in October 1995 with Vinod Mehta as the editor in chief. It is owned by the Rajan Raheja Group. The publisher is Outlook Publishing (India) Pvt. Ltd. It features contents from politics, sports, cinema, and stories of broad interests. By December 2018, ''Outlook'' magazine's Facebook following had grown to over 12 lakh A lakh (; abbreviated L; sometimes written lac) is a unit in the Indian numbering system equal to one hundred thousand (100,000; scientific notation: 105). In the Indian 2,2,3 convention of digit grouping, it is written as 1,00,000. For ex ... (1.2 million). Staff Editor *Chinki Sinha Editors-in-chief * Vinod Mehta (1995 - 2012) * Krishna Prasad (2012–2016) *Rajesh Ramachandran (2016-2018) Managing editors * Tarun Tejpal (1995 - March 2000) [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVAX
COVID-19 Vaccines Global Access, abbreviated as COVAX, is a worldwide initiative aimed at equitable access to COVID-19 vaccines directed by the GAVI vaccine alliance, the Coalition for Epidemic Preparedness Innovations (CEPI), and the World Health Organization (WHO), alongside key delivery partner UNICEF. It is one of the four pillars of the Access to COVID-19 Tools Accelerator, an initiative begun in April 2020 by the WHO, the European Commission, and the government of France as a response to the COVID-19 pandemic. COVAX coordinates international resources to enable low-to-middle-income countries equitable access to COVID-19 tests, therapies, and vaccines. UNICEF is the key delivery partner, leveraging its experience as the largest single vaccine buyer in the world and working on the procurement of COVID-19 vaccine doses, as well as logistics, country readiness and in-country delivery. By 19 October 2020, 184 countries had joined COVAX. COVAX began distributing vaccines i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ministry Of Health And Family Welfare
The Ministry of Health and Family Welfare is an Indian government ministry charged with health policy in India. It is also responsible for all government programs relating to family planning in India. The Minister of Health and Family Welfare holds cabinet rank as a member of the Council of Ministers. The current minister is Mansukh L. Mandaviya, while the current Minister of State for health (MOS: assistant to Minister i.e. currently assistant to Mansukh L. Mandaviya) is Dr Bharati Pawar . Since 1955 the Ministry regularly publishes the Indian Pharmacopoeia through the Indian Pharmacopoeia Commission (IPC), an autonomous body for setting standards for drugs, pharmaceuticals and healthcare devices and technologies in India. Organisation The ministry is composed of two departments: Department of Health and Family Welfare and the Department of Health Research. Department of Health The Department of Health deals with health care, including awareness campaigns, immunisa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tito's Vodka
Tito's Handmade Vodka is a vodka brand made by Fifth Generation, founded by Tito Beveridge in 1997 in Austin, Texas – specializing in vodka made from yellow corn, rather than potatoes or wheat. It is distilled 6 times and unaged. Marketing its brand as ''Tito's Handmade Vodka'', the company originally craft-distilled its products in copper pot stills at Texas' first legal distillery. By 2001, the brand was no longer a micro-distillery, having surpassed the industry standard of 40,000 cases for a craft distillery as defined by the Distilled Spirits Council of the United States (DISCUS). Now made in a facility with ten-floor-to-ceiling stills and equipment bottling 500 cases an hour, the brand recorded a sales volume of approximately 3.8 million 9-liter cases in the United States as of 2016 and a market share of 7.1% of the United States Vodka market as of 2017. Founder Bert Butler "Tito" Beveridge II is a native of San Antonio, Texas. He received the diminutive nickna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drugs Controller General Of India
Drugs Controller General of India (DCGI) is the head of department of the Central Drugs Standard Control Organization of the Government of India responsible for approval of licences of specified categories of drugs such as blood and blood products, IV fluids, vaccines, and sera in India. Drugs Controller General of India, comes under the Ministry of Health & Family Welfare. DCGI also sets standards for manufacturing, sales, import, and distribution of drugs in India. Function DCGI lays down the standard and quality of manufacturing, selling, import and distribution of drugs in India. * Preparation and maintenance of national reference standard. * To bring about the uniformity in the enforcement of the Drugs and Cosmetics Act. * Training of Drug Analysts deputed by State Drug Control Laboratories and other Institutions * Analysis of Cosmetics received as survey samples from CDSCO (central drug standard control organisation) With the notification of Medical Device Rules ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis B Vaccine
Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either two or three more doses given after that. This includes those with poor immune function such as from HIV/AIDS and those born premature. It is also recommended that health-care workers be vaccinated. In healthy people routine immunization results in more than 95% of people being protected. Blood testing to verify that the vaccine has worked is recommended in those at high risk. Additional doses may be needed in people with poor immune function but are not necessary for most people. In those who have been exposed to the hepatitis B virus (HBV) but not immunized, hepatitis B immune globulin should be given in addition to the vaccine. The vaccine is given by injection into a muscle. Serious side effects from the hepatitis B vaccine are very uncommon. Pain may occur at the site of injection. It is safe for use during pregnancy or while breastfeedin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pichia Pastoris
''Pichia pastoris'' is a species of methylotrophic yeast. It was found in the 1960s, with its feature of using methanol as a source of carbon and energy. After years of study, ''P. pastoris'' was widely used in biochemistry, biochemical research and biotechnology, biotech industries. With strong potential for being an Gene expression, expression system for protein production, as well as being a model organism for genetic study, ''P. pastoris'' has become important for biological research and biotech applications. In the last decade, some reports reassigned ''P. pastoris'' to the genus ''Komagataella'' with Phylogenetics, phylogenetic analysis, by DNA sequencing, genome sequencing of ''P. pastoris''. The genus was split into ''K. phaffii'', ''K. pastoris'', and ''K. pseudopastoris''. ''P. pastoris'' in nature Natural habitat In nature, ''P. pastoris'' is found on trees, such as Chestnut , chestnut trees. They are heterotrophs and they can use several carbon sources for living, li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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