Biflavonoid
Biflavonoids are a type of flavonoids with the general formula scheme (C6-C3-C6)2. Examples * Amentoflavone (bis-apigenin coupled at 8 and 3' positions) * Lophirone L and lophirone M found in ''Lophira alata'' * Sulcatone A, a naturally occurring biflavonoid isolated from ''Ouratea sulcata''. Extracts of the leaves of this plant, used with and with other plant's extracts, are used in many African countries to treat some infections such as upper tract respiratory infections, dysenteria, diarrhoea and toothache. Positive antimicrobial activity has been shown in-vitro against ''Staphylococcus aureus'' and ''Bacillus subtilis''. ''Escherichia coli'' showed to be resistant in the same study. * Hinokiflavone, a cytotoxic biflavonoid from '' Toxicodendron succedaneum'', ''Juniperus sp.'', or ''Chamaecyparis obtusa'' (hinoki). * Leaflets of '' Cycas circinalis'' and '' C. revoluta'' contain biflavonoids such as (2''S'', 2′′''S'')-2,3,2′′,3′′-tetrahydro-4′,4′′′-di-'' ...
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Ochnaflavone
Ochnaflavone, a secondary plant secondary metabolite of the Biflavonoid family, has been widely investigated in past decades due to its unique ability to mediate biological activities, such as inhibition of phospholipase A2 and lymphocyte proliferation. It was first isolated from '' Ochna squarrosa'' Linn, a member of Ochnaceae family, in 1973. Synthesis The first total synthesis of ochnaflavone derivatives was achieved by Kawano group in 1973, followed by the Heerden group for the first time reporting the total synthesis the ochnaflavone by constructing a diaryl ether intermediate and assemble the two flavone nuclei through ring cyclization. To date, the field of biochemistry of biflavonoids is still wide open. Little is known about Ochnaflavone of its natural occurrence and biosyn