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Bifidobacterium Longum
''Bifidobacterium longum'' is a Gram-positive, catalase-negative, rod-shaped bacterium present in the human gastrointestinal tract and one of the 32 species that belong to the genus ''Bifidobacterium''. It is a microaerotolerant anaerobe and considered to be one of the earliest colonizers of the gastrointestinal tract of infants. When grown on general anaerobic medium, ''B. longum'' forms white, glossy colonies with a convex shape. ''B. longum'' is one of the most common bifidobacteria present in the gastrointestinal tracts of both children and adults. ''B. longum'' is non-pathogenic, is often added to food products, and its production of lactic acid is believed to prevent growth of pathogenic organisms. Classification In 2002, three previously distinct species of ''Bifidobacterium'', ''B. infantis'', ''B. longum'', and ''B. suis'', were unified into a single species named ''B. longum'' with the biotypes ''infantis, longum,'' and ''suis'', respectively. This occurred as the thr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Reuter
Gerhard is Gerard, a name of Germanic origin and may refer to: Given name * Gerhard (bishop of Passau) (fl. 932–946), German prelate * Gerhard III, Count of Holstein-Rendsburg (1292–1340), German prince, regent of Denmark * Gerhard Barkhorn (1919–1983), German World War II flying ace * Gerhard Berger (born 1959), Austrian racing driver * Gerhard Boldt (1918–1981), German soldier and writer * Gerhard de Beer (born 1994), South African football player * Gerhard Diephuis (1817–1892), Dutch jurist * Gerhard Domagk (1895–1964), German pathologist and bacteriologist and Nobel Laureate * Gerhard Dorn (c.1530–1584), Flemish philosopher, translator, alchemist, physician and bibliophile * Gerhard Ertl (born 1936), German physicist and Nobel Laureate * Gerhard Fieseler (1896–1987), German World War I flying ace * Gerhard Flesch (1909–1948), German Nazi Gestapo and SS officer executed for war crimes * Gerhard Gentzen (1909–1945), German mathematician and logician * Gerhard Ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endothelial Cells
The endothelium (: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells in direct contact with blood are called vascular endothelial cells whereas those in direct contact with lymph are known as lymphatic endothelial cells. Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. These cells have unique functions that include fluid filtration, such as in the glomerulus of the kidney, blood vessel tone, hemostasis, neutrophil recruitment, and hormone trafficking. Endothelium of the interior surfaces of the heart chambers is called endocardium. An impaired function can lead to serious health issues throughout the body. Structure The endothelium is a thin layer of single flat (squamous) cells that line the interior s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumors
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, which may be called a tumour or tumor.'' ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, such as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word neoplasm is from Ancient Greek 'new' and 'formation, creation'. Types A neoplas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VSL(3)
The De Simone Formulation is a probiotic formula and manufacturing method developed by Claudio De Simone. The De Simone Formulation has been clinically studied for a variety of health conditions since the 1990s but it has been researched the most for its efficacy in the medical management of chronic intestinal conditions including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Lawsuits The De Simone Formulation has been the subject of lawsuits. In the United States, the 4th U.S. Circuit Court of Appeals upheld a false advertising verdict against the makers of the VSL#3 probiotic in February 2021 stating there was enough evidence to support a jury's November 2018 finding that the makers of VSL#3 had quote "reverse-engineered an imperfect copy" of De Simone's signature probiotic formulation that was sold under the brand name VSL#3 through May 2016 after he withdrew from their joint venture, VSL Pharmaceuticals Inc. According to the lawsuit, his departure wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Milk Oligosaccharide
Human milk oligosaccharides (HMOs), also known as human milk glycans, are short polymers of Monosaccharide, simple sugars that can be found in high concentrations in Breast milk, human breast milk. Human milk oligosaccharides promote the development of the immune system, can reduce the risk of pathogen infections and improve brain development and cognition. The HMO profile of human breast milk shapes the gut microbiota of the infant by selectively stimulating Bifidobacterium, bifidobacteria and other bacteria. Functions In contrast to the other components of breast milk that are absorbed by the infant through breastfeeding, HMOs are Digestion, indigestible for the nursing child. However, they have a Prebiotic (nutrition), prebiotic effect and serve as food for intestinal bacteria, especially Bifidobacterium, bifidobacteria. The dominance of these intestinal bacteria in the gut reduces the colonization with Pathogen#Pathogenicity, pathogenic bacteria (probiosis) and thereby pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bile Salt Hydrolase
Bile salt hydrolases (BSH) are microbial enzymes that deconjugate primary bile acids. They catalyze the first step of bile acid metabolism and maintain the bile acid pool for further modification by the microbiota. BSH enzymes play a role in a range of host and microbe functions including host physiology, immunity, and protection from pathogens. Structure Bile salt hydrolases are members of the N-terminal nucleophilic hydrolase family, characterized by autocatalytic activation by an N-terminal nucleophile and subsequent amide bond cleavage. The majority of BSH enzymes are composed of homotetramers, although they have been known to assume other forms including homodimers and heterotrimers. All BSHs contain a catalytic Cys2 nucleophile residue, which is located at the N-terminus of the enzyme. While BSH structure may vary, other amino acids have been shown to be conserved across BSH-carrying bacteria. These include Arg18, Asp21, Asn82, and Arg228. Bile acid metabolism Deconj ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acids
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the Proteinogenic amino acid, 22 α-amino acids incorporated into proteins. Only these 22 appear in the genetic code of life. Amino acids can be classified according to the locations of the core structural functional groups (Alpha and beta carbon, alpha- , beta- , gamma- (γ-) amino acids, etc.); other categories relate to Chemical polarity, polarity, ionization, and side-chain group type (aliphatic, Open-chain compound, acyclic, aromatic, Chemical polarity, polar, etc.). In the form of proteins, amino-acid ''Residue (chemistry)#Biochemistry, residues'' form the second-largest component (water being the largest) of human muscles and other tissue (biology), tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Horizontal Gene Transfer
Horizontal gene transfer (HGT) or lateral gene transfer (LGT) is the movement of genetic material between organisms other than by the ("vertical") transmission of DNA from parent to offspring (reproduction). HGT is an important factor in the evolution of many organisms. HGT is influencing scientific understanding of higher-order evolution while more significantly shifting perspectives on bacterial evolution. Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria, and plays an important role in the evolution of bacteria that can degrade novel compounds such as human-created Bactericide, pesticides and in the evolution, maintenance, and transmission of virulence. It often involves Temperateness (virology), temperate bacteriophages and plasmids. Genes responsible for antibiotic resistance in one species of bacteria can be transferred to another species of bacteria through various mechanisms of HGT such as Transformation (genetics), tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene. Gene duplications can arise as products of several types of errors in DNA replication and repair machinery as well as through fortuitous capture by selfish genetic elements. Common sources of gene duplications include ectopic recombination, retrotransposition event, aneuploidy, polyploidy, and replication slippage. Mechanisms of duplication Ectopic recombination Duplications arise from an event termed unequal crossing-over that occurs during meiosis between misaligned homologous chromosomes. The chance of it happening is a function of the degree of sharing of repetitive elements between two chromosomes. The products of this recombination are a duplication at the site of the exchange and a reciprocal deletion. Ectopic recombina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Gum
Natural gums are polysaccharides of natural origin, capable of causing a large increase in a solution's viscosity, even at small concentrations. They are mostly gum (botany), botanical gums, found in the woody elements of plants or in seed coatings. Human uses Gums are used in the food industry as thickening agents, gelling agents, Emulsion, emulsifying agents, and Food additive#Categories , stabilizers, and in other industrial adhesives, Excipient#Types, binding agents, crystal inhibitors, Brewing#Ingredients, clarifying agents, encapsulating agents, Flocculation , flocculating agents, swelling agents, foam stabilizers, etc. When consumed by humans, many of these gums are fermented by the microbes that inhabit the lower gastrointestinal tract (microbiome) and may influence the ecology and functions of these microscopic communities. Commercial significance Humans have used natural gums for various purposes, including chewing gum , chewing and the manufacturing of a wide rang ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrolases
In biochemistry, hydrolases constitute a class of enzymes that commonly function as biochemical catalysts that use water to break a chemical bond: :\ce \quad \xrightarrowtext\quad \ce This typically results in dividing a larger molecule into smaller molecules. Some common examples of hydrolase enzymes are esterases including lipases, phosphatases, glycosidases, peptidases, and nucleosidases. Esterases cleave ester bonds in lipids and phosphatases cleave phosphate groups off molecules. An example of crucial esterase is acetylcholine esterase, which assists in transforming the neuron impulse into the acetate group after the hydrolase breaks the acetylcholine into choline and acetic acid. Acetic acid is an important metabolite in the body and a critical intermediate for other reactions such as glycolysis. Lipases hydrolyze glycerides. Glycosidases cleave sugar molecules off carbohydrates and peptidases hydrolyze peptide bonds. Nucleosidases hydrolyze the bonds of nucleoti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATP-binding Cassette
The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters belong to translocases. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate. Most of the uptake systems also have an extracytoplasmic receptor, a solute binding protein. Some homologous ATPases function in non-transport-related processes such as translation of RNA and DNA repair. ABC transporters are considered to be an ABC superfamily based on the similarities of the sequence and organiz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
