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Barbara Mawer
Elizabeth Barbara Mawer (née Entwistle, 6 March 1936 – 7 March 2006) was a British biochemist and medical researcher. She was regarded as a "highly influential figure in the calcium homoeostasis field". Early life and education Barbara Entwistle was born on 6 March 1939 in Blackburn to Thomas Entwistle, a teacher, and Gladys Mary Entwistle (née Cornall). She attended Blackburn High School and Queen Mary School in Lytham St Annes. She received a BSc in biochemistry from the University of Edinburgh in 1957. She stayed there to conduct research, supervised by Guy Marrian, and in 1961 received a PhD for her thesis entitled ''The metabolism of cholesterol in the animal body''. From 1958 to 1963 she also worked as an assistant lecturer at Edinburgh. Scientific career After taking a break from working in order to look after her young children, in 1967 Mawer became a research associate at the University of Manchester, studying vitamin D and metabolic bone disease with Willi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blackburn
Blackburn () is an industrial town and the administrative centre of the Blackburn with Darwen borough in Lancashire, England. The town is north of the West Pennine Moors on the southern edge of the River Ribble, Ribble Valley, east of Preston, Lancashire, Preston and north-northwest of Manchester. Blackburn is at the centre of the wider unitary authority area along with the town of Darwen. It is the second largest town (after Blackpool) in Lancashire. At the United Kingdom Census 2011, 2011 census, Blackburn had a population of List of urban areas in England by population, 117,963, whilst the wider borough of Blackburn with Darwen had a population of List of English districts by population, 150,030. Blackburn had a population of 117,963 in 2011, with 30.8% being people of ethnic backgrounds other than white British. A former mill town, Blackburn has been the site of textile production since the mid-13th century, when wool was woven in people's houses in the domestic sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcium
Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to its heavier homologues strontium and barium. It is the fifth most abundant element in Earth's crust, and the third most abundant metal, after iron and aluminium. The most common calcium compound on Earth is calcium carbonate, found in limestone and the fossils of early sea life; gypsum, anhydrite, fluorite, and apatite are also sources of calcium. The name comes from Latin ''calx'' " lime", which was obtained from heating limestone. Some calcium compounds were known to the ancients, though their chemistry was unknown until the seventeenth century. Pure calcium was isolated in 1808 via electrolysis of its oxide by Humphry Davy, who named the element. Calcium compounds are widely used in many industries: in foods and pharmaceuticals for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver Cancer
Liver cancer, also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy, is cancer that starts in the liver. Liver cancer can be primary in which the cancer starts in the liver, or it can be liver metastasis, or secondary, in which the cancer spreads from elsewhere in the body to the liver. Liver metastasis is the more common of the two liver cancers. Instances of liver cancer are increasing globally. Primary liver cancer is globally the sixth-most frequent cancer and the fourth-leading cause of death from cancer. In 2018, it occurred in 841,000 people and resulted in 782,000 deaths globally. Higher rates of liver cancer occur where hepatitis B and C are common, including Asia and sub-Saharan Africa. Males are more often affected with hepatocellular carcinoma (HCC) than females. Diagnosis is most frequent among those 55 to 65 years old. The leading cause of liver cancer is cirrhosis due to hepatitis B, hepatitis C, or alcohol. Other causes include af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christie Hospital
The Christie, formerly known as Christie Hospital and The Christie Hospital and Holt Radium Institute, is a specialist National Health Service, National Health Service (NHS) single site cancer centre in Manchester, United Kingdom. The hospital is managed by The Christie NHS Foundation Trust, which had a turnover of £472 million and around 3,500 staff. Its work is supported by The Christie Charity. The hospital was established in 1890 by Richard Copley Christie, after whom, along with his wife Mary, it is named. Initially situated off Oxford Road, Manchester, Oxford Road in Manchester, the centre moved to a purpose-built facility in Withington in 1932 and became part of the National Health Service, NHS in 1948. Treatments and facilities The Christie is the largest single site cancer centre in Europe, and during the 2023–24 period provided 102,000 fractions of radiotherapy and treated more than 60,000 patients. It is the largest radiotherapy provider in the NHS, and similarly c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, functions, sources, synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug. In broad terms, pharmacod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
North West Regional Assembly
The North West Regional Assembly (NWRA) was the regional chamber for the North West England region of the England. It was based at Wigan, in Greater Manchester. It was abolished in July 2008. Creation and functions The assembly was created by the Regional Development Agencies Act 1998. The first meeting was held in 1999. In July 2003 the assembly was reconstituted to combine its existing functions with those of the regional arm of the Local Government Association and of the Regional Employers Organisation. The NWRA acted as the representative voice of the region and worked to promote the economic, environmental and social well-being of the North West of England. The key functions of the assembly were: *Co-ordinate the public expenditure of local authorities *Act as regional planning body *Scrutinise the work of the Northwest Regional Development Agency Abolition Following criticism of the regional assemblies, it was proposed in July 2007 that they will be axed, losing th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liberal Democrats (UK)
The Liberal Democrats, colloquially known as the Lib Dems, are a Liberalism, liberal political party in the United Kingdom, founded in 1988. They are based at Liberal Democrat Headquarters (UK), Liberal Democrat Headquarters, in Westminster, and the leader is Ed Davey. They are the third-largest political party in the United Kingdom, party in the United Kingdom, with 72 Member of Parliament (United Kingdom), members of Parliament (MPs) in the House of Commons of the United Kingdom, House of Commons. They have members of the House of Lords, 5 in the Scottish Parliament, 1 in the Welsh Senedd, and more than 3,000 local council seats. The party holds a twice yearly Liberal Democrat Conference, at which policy is formulated. In contrast to its main opponents, the Lib Dems Liberal Democrat Conference#All-member Conference voting system, grant all members attending Conference the right to vote on policy, under a one member, one vote#United Kingdom, one member, one vote system. The p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warrington Borough Council
Warrington Borough Council is the local authority of the Borough of Warrington, a local government district in the ceremonial county of Cheshire, England. Warrington has had a borough council since 1847, which has been reformed on several occasions. Since 1998 the council has been a unitary authority, being a district council which also performs the functions of a county council. The council has been under Labour majority control since 2011. It meets at Warrington Town Hall and has its main offices at 1 Time Square. History The town of Warrington was made a municipal borough in 1847, governed by a body formally called the "mayor, aldermen and burgesses of the borough of Warrington", generally known as the corporation, town council or borough council. This first incarnation of the borough council replaced an earlier body of improvement commissioners which had governed the town since 1813. From its creation in 1847 the borough straddled Lancashire and Cheshire, with the county b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warrington
Warrington () is an industrial town in the Borough of Warrington, borough of the same name in Cheshire, England. The town sits on the banks of the River Mersey and was Historic counties of England, historically part of Lancashire. It is east of Liverpool and the same distance west of Manchester. The population in 2021 was recorded as 174,970 for the built-up area and 210,900 for the wider borough, the latter being more than double that of 1968 when it became a New towns in the United Kingdom, new town. Warrington is the largest town in the ceremonial county of Cheshire. Warrington was founded by the Roman Britain, Romans at an important crossing place on the River Mersey. A new settlement was established by the Saxons, Saxon Wærings. By the Middle Ages, Warrington had emerged as a market town at the lowest bridging point of the river. A local tradition of textile and tool production dates from this time. The expansion and urbanisation of Warrington coincided with the Industr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thelwall
Thelwall is a suburban village in the civil parish of Grappenhall and Thelwall, in the Warrington district, in the ceremonial county of Cheshire, England. It is close to the Lymm junction of the M6 motorway. History A fortified village was established at Thelwall in 923, in the reign of King Edward the Elder, which is mentioned in two very early sources, including the ''Anglo-Saxon Chronicle'': "Kynge Edwarde made a cite at Thelewall in h northe parte of h Marches, nye the water of Mersee, where he put certeyne knyghtes."—Higden's Polychronicon "A.D. 923. This year went King Edward with an army, late in the harvest, to Thelwall; and ordered the borough to be repaired, and inhabited, and manned. And he ordered another army also from the population of Mercia, the while he sat there to go to Manchester in Northumbria, to repair and to man it. This year died Archbishop Plegmund; and King Reynold won York."—''Anglo-Saxon Chronicle'' An inscription on the Pickering Arms rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bone Research Society
A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions. Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue. It has a honeycomb-like matrix internally, which helps to give the bone rigidity. Bone tissue is made up of different types of bone cells. Osteoblasts and osteocytes are involved in the formation and mineralisation of bone; osteoclasts are involved in the resorption of bone tissue. Modified (flattened) osteoblasts become the lining cells that form a protective layer on the bone surface. The mineralised matrix ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assay Sensitivity
Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions. Importance Lack of assay sensitivity has different implications for trials intended to show a difference greater than zero between interventions (superiority trials) and trials intended to show non-inferiority. Non-inferiority trials attempt to rule out some margin of inferiority between a test and control intervention i.e. rule out that the test intervention is no worse than the control intervention by a chosen amount. If a trial intended to demonstrate efficacy by showing superiority of a test intervention to control lacks assay sensitivity, it will fail to show that the test intervention is superior and will fail to lead to a conclusion of efficacy. In contrast, if a trial i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
