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Balanitis Circinata
Balanitis circinata (also known as circinate balanitis) is a skin condition comprising a serpiginous ring-shaped dermatitis of the glans penis. While circinate balanitis is one of the most common cutaneous manifestations of reactive arthritis, it can also occur independently. Topical corticosteroid therapy is the most commonly used treatment, and topical calcineurin inhibitors have also been used successfully. Signs and symptoms At the first stages of the condition, patients show pinhead-sized lesions covered by white plaque, which grow into a flat, red region with a white margin. Despite the visible symptoms, patients rarely suffer from burning or itching, and the lesions rarely smell strange. Due to its visual appearance, balanitis circinata is often misdiagnosed as a fungal infection, especially in those that have no other symptoms of reactive arthritis. Cause Reactive arthritis is characterized by nongonococcal urethritis, conjunctivitis, and arthritis. Reactive arthrit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatology
Dermatology is the branch of medicine dealing with the Human skin, skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A List of dermatologists, dermatologist is a specialist medical doctor who manages diseases related to skin. Etymology Attested in English in 1819, the word "dermatology" derives from the Ancient Greek, Greek δέρματος (''dermatos''), genitive of δέρμα (''derma''), "skin" (itself from δέρω ''dero'', "to flay") and -λογία ''wikt:-logia, -logia''. Neo-Latin ''dermatologia'' was coined in 1630, an anatomical term with various French and German uses attested from the 1730s. History In 1708, the first great school of dermatology became a reality at the famous Hôpital Saint-Louis in Paris, and the first textbooks (Willan's, 1798–1808) and atlases (Jean-Louis-Marc Alibert, Alibert's, 1806–1816) appeared in print around the same time.Freedber ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthritis
Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of the affected joints. In certain types of arthritis, other organs such as the skin are also affected. Onset can be gradual or sudden. There are several types of arthritis. The most common forms are osteoarthritis (most commonly seen in weightbearing joints) and rheumatoid arthritis. Osteoarthritis usually occurs as an individual ages and often affects the hips, knees, shoulders, and fingers. Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. Other types of arthritis include gout, lupus, and septic arthritis. These are inflammatory based types of rheumatic disease. Early treatment for arthritis commonly includes resting the affected joint and conservative measures such as heating or icing. Weight Weight ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urological Conditions
Urologic diseases or conditions include urinary tract infections, kidney stones, bladder control problems, and prostate problems, among others. Some urologic conditions do not affect a person for that long and some are lifetime conditions. Kidney diseases are normally investigated and treated by nephrologists, while the specialty of urology deals with problems in the other organs. Gynecologists may deal with problems of incontinence in women. Diseases of other bodily systems also have a direct effect on urogenital function. For instance, it has been shown that protein released by the kidneys in diabetes mellitus sensitizes the kidney to the damaging effects of hypertension. Diabetes also can have a direct effect on urination due to peripheral neuropathies, which occur in some individuals with poorly controlled diabetics. Kidney disease Kidney disease, or renal disease, also known as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JAMA Dermatology
''JAMA Dermatology'' is a monthly peer-reviewed medical journal published by the American Medical Association. It covers the effectiveness of diagnosis and treatment in medical and surgical dermatology, pediatric and geriatric dermatology, and oncologic and aesthetic dermatologic surgery. The journal was established in the ''Archives of Dermatology and Syphilology'' (1920–1950), continuing as the ''A.M.A. Archives of Dermatology and Syphilology'' (1950–1954), then ''A.M.A. Archives of Dermatology'' (1955–1960), then ''Archives of Dermatology'' (1960–2012), obtaining its current name in January 2013. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 11.816, ranking it 2nd out of 69 journals in the category "Dermatology". The editor-in-chief is Kanade Shinkai (University of California, San Francisco). Abstracting and indexing The journal is abstracted and indexed in Index Medicus/MEDLINE/PubMed. See also *List of American Medical Associati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tacrolimus
Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After Allotransplantation, allogenic organ transplant, the risk of organ Transplant rejection, rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T cell-mediated diseases such as atopic dermatitis, eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat Dry eye syndrome#Other, dry eye syndrome in cats and dogs. Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and cell proliferation, proliferation of T cells, as part of the body's learned (or adaptive immune response, adaptive) immune response. Chemically, it is a macrolide lactone that was first discovered in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pimecrolimus
Pimecrolimus is an immunosuppressant drug of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema). It is available as a topical cream. It was developed and formerly marketed by Novartis under the trade name Elidel. Medical uses It has been proven to be effective in various inflammatory skin diseases, e.g., seborrheic dermatitis, cutaneous lupus erythematosus, oral lichen planus, vitiligo, and psoriasis. Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants. Atopic dermatitis If topical corticosteroids and moisturisers fail in the treatment of atopic dermatitis, short-term treatment with topical calcineurin inhibitors such as tacrolimus or pimecrolimus may be tried. Both tacrolimus and pimecrolimus are effective and safe to use in AD. Side effects In January 2006, the United States Food and Drug Administration (FDA) announced that Elidel packaging would be required to carry a black box warning reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunomodulator
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherapies that reduce or suppress are classified as '' suppression immunotherapies''. Immunotherapy is under preliminary research for its potential to treat various forms of cancer. Cell-based immunotherapies are effective for some cancers. Immune effector cells such as lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes work together to defend the body against cancer by targeting abnormal antigens expressed on the surface of tumor cells. Vaccine-induced immunity to COVID-19 relies mostly on an immunomodulatory T-cell response. Therapies such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and cellular membrane fractions from bacteria are licensed for medical use. Others inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Off-label Use
Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration. Both prescription drugs and over-the-counter drugs (OTCs) can be used in off-label ways, although most studies of off-label use focus on prescription drugs. Off-label use is very common and generally legal unless it violates ethical guidelines or safety regulations. The ability to prescribe drugs for uses beyond the officially approved indications is commonly used to good effect by healthcare providers. For example, methotrexate is commonly used off-label because its immunomodulatory effects relieve various disorders. However, off-label use can entail health risks and differences in legal liability. Marketing of pharmaceuticals for off-label use is usually prohibited. Indications and labeling laws An '' indication'' is when a drug is medically appropriate for a given condition; an approved indication is when a government drug regula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Balanitis Circinata During Pimecrolimus Treatment
Balanitis is inflammation of the glans penis. Balanoposthitis is the proper term when the foreskin is also affected. Balanitis on boys in diapers must be distinguished from redness caused by ammoniacal dermatitis. Etymology The word ''balanitis'' is from the Greek βάλανος'' '', literally meaning 'acorn' because of the similarity in shape to the glans penis. ''-Itis'' is a suffix from the Greek for 'inflammation'. ''Posthe'' is the Greek word meaning 'foreskin'. Signs and symptoms * Small red erosions on the glans (first sign) * Redness of the foreskin * Redness of the penis * Other rashes on the head of the penis * Foul-smelling discharge * Painful foreskin and penis Complications Recurrent bouts of balanitis may cause scarring of the preputial orifice; the reduced elasticity may lead to pathologic phimosis. Further complications may include: * Stricture of urinary meatus * Paraphimosis Causes Inflammation has many possible causes, including irritation by environmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlamydia Trachomatis
''Chlamydia trachomatis'' () is a Gram-negative, Anaerobic organism, anaerobic bacterium responsible for Chlamydia infection, chlamydia and trachoma. ''C. trachomatis'' exists in two forms, an extracellular infectious elementary body (EB) and an intracellular non-infectious reticulate body (RB). The EB attaches to host cells and enter the cell using Effector (biology), effector proteins, where it transforms into the metabolically active RB. Inside the cell, RBs rapidly replicate before transitioning back to EBs, which are then released to infect new host cells. The earliest description of ''C. trachomatis'' was in 1907 by Stanislaus von Prowazek and Ludwig Halberstädter as a protozoan. It was later thought to be a virus due to its small size and inability to grow in laboratories. It was not until 1966 when it was discovered as a bacterium by Electron microscope, electron microscopy after its internal structures were visually observed. There are currently 18 Serotype, serovars of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
