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Axel Schumacher
Axel Schumacher (born June 14, 1969), is a German epigenetics researcher. He invented the first microarray technologies for epigenetic biomarker discovery, developed the '' epigenetic theory of aging'' with his research leading to the worldwide first proof of whole genome epigenetic abnormalities in Alzheimer's disease. Alongside his work as a scientist he is a published author, a futurologist and as of July 2017, CEO and co-founder of the HLTH.network. Early life and education Schumacher was born in Kreuztal, Germany in 1969. Schumacher was awarded with a PhD in biology from University of Cologne under the supervision of laureate in 2002. Career Epigenetics Schumacher started his career in epigenetics as a visiting researcher at the laboratory of Wolf Reik at the Babraham Institute near Cambridge, England working on DNA methylation and genomic imprinting. During his career he made several breakthrough discoveries including, how genomic imprinting is regulated by DNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kreuztal
Kreuztal is a town in the Siegen-Wittgenstein district, in North Rhine-Westphalia, Germany. Geography Location Kreuztal is a town in the low mountains of the northern Siegerland and lies at the western edge of the Rothaargebirge about 10 km north of Siegen. Across the municipal area from the east flows the Ferndorfbach, swinging to the south in the inner town and leaving the municipal area through the constituent community of Buschhütten. In the northern municipal area rises the Littfe, which then runs through the constituent communities of Burgholdinghausen, Littfeld, Krombach, Eichen and Fellinghausen before emptying into the Ferndorfbach in the inner town. Further tributary brooks to the Littfe are the Langebach, the Heimkäuser Bach, the Breitenbach, the Krombach, the Stendenbach and the Bockenbach. In the town's west end rises the Heesbach, which then runs through the constituent communities of Oberhees, Mittelhees, Junkernhees and Fellinghausen, emptying into the Li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heavy Metal (magazine)
''Heavy Metal'' is an American science fantasy comics magazine, first published in 1977. The magazine is known primarily for its blend of dark fantasy, science fiction, erotica, and steampunk comics. Following a brief hiatus in 2023, it plans to relaunch in 2024 with new owners and a new editorial team consisting of Dave Kelly, Frank Forte, and Chris Thompson. Unlike the traditional American comic books of that time bound by the restrictive Comics Code Authority, the magazine-format ''Heavy Metal'' featured explicit nudity, sexual situations, and graphic violence. The magazine started out primarily as a licensed translation of the French science-fantasy magazine ''Métal hurlant'', marking for many Americans their first introduction to the work of European cartoonists like Enki Bilal, Caza, Philippe Caza, Guido Crepax, Philippe Druillet, Jean-Claude Forest, Jean Giraud (a.k.a. Moebius), Chantal Montellier, and Milo Manara. Publication history National Lampoon After a 1975 Eur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1969 Births
1969 (Roman numerals, MCMLXIX) was a common year starting on Wednesday of the Gregorian calendar, the 1969th year of the Common Era (CE) and ''Anno Domini'' (AD) designations, the 969th year of the 2nd millennium, the 69th year of the 20th century, and the 10th and last year of the 1960s decade. Events January * January 4 – The Government of Spain hands over Ifni to Morocco. * January 5 – Ariana Afghan Airlines Flight 701 crashes into a house on its approach to London's Gatwick Airport, killing 50 of the 62 people on board and two of the home's occupants. * January 14 – USS Enterprise fire, An explosion aboard the aircraft carrier USS Enterprise (CVN-65), USS ''Enterprise'' near Hawaii kills 28 and injures 314. * January 16 – First successful docking of two crewed spacecraft in orbit and the first transfer of crew from one space vehicle to another (by a space walk) between Soviet craft Soyuz 5 and Soyuz 4. * January 18 – Failure of Soyuz 5's service module to separ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Comics Writers
German(s) may refer to: * Germany, the country of the Germans and German things **Germania (Roman era) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizenship in Germany, see also German nationality law **Germanic peoples (Roman era) *German diaspora * German language * German cuisine, traditional foods of Germany People * German (given name) * German (surname) * Germán, a Spanish name Places * German (parish), Isle of Man * German, Albania, or Gërmej * German, Bulgaria * German, Iran * German, North Macedonia * German, New York, U.S. * Agios Germanos, Greece Other uses * German (mythology), a South Slavic mythological being * Germans (band), a Canadian rock band * "German" (song), a 2019 song by No Money Enterprise * ''The German'', a 2008 short film * "The Germans", an episode of ''Fawlty Towers'' * ''The German'', a nickname for Congolese rebel André Kisase Ngandu See also * Germanic (disambiguati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cologne Alumni
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Kreuztal
The term "the people" refers to the public or common mass of people of a polity. As such it is a concept of human rights law, international law as well as constitutional law, particularly used for claims of popular sovereignty. In contrast, a people is any plurality of persons considered as a whole. Used in politics and law, the term "a people" refers to the collective or community of an ethnic group or nation. Concepts Legal Chapter One, Article One of the Charter of the United Nations states that "peoples" have the right to self-determination. Though the mere status as peoples and the right to self-determination, as for example in the case of Indigenous peoples (''peoples'', as in all groups of indigenous people, not merely all indigenous persons as in ''indigenous people''), does not automatically provide for independent sovereignty and therefore secession. Indeed, judge Ivor Jennings identified the inherent problems in the right of "peoples" to self-determination, as i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Geneticists
German(s) may refer to: * Germany, the country of the Germans and German things **Germania (Roman era) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizenship in Germany, see also German nationality law **Germanic peoples (Roman era) *German diaspora * German language * German cuisine, traditional foods of Germany People * German (given name) * German (surname) * Germán, a Spanish name Places * German (parish), Isle of Man * German, Albania, or Gërmej * German, Bulgaria * German, Iran * German, North Macedonia * German, New York, U.S. * Agios Germanos, Greece Other uses * German (mythology), a South Slavic mythological being * Germans (band), a Canadian rock band * "German" (song), a 2019 song by No Money Enterprise * ''The German'', a 2008 short film * "The Germans", an episode of ''Fawlty Towers'' * ''The German'', a nickname for Congolese rebel André Kisase Ngandu See also * Germanic (disambigu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetic Clock
An epigenetic clock is a Biomarkers of aging, biochemical test that can be used to measure age. The test is based on modifications that change over time and regulate how genes are expressed. Typically, the test examines DNA methylation levels, measuring the accumulation of methyl groups to one's DNA molecules, or more recently, based on the histone code. History The strong effects of age on DNA methylation levels have been known since the late 1960s. A vast literature describes sets of CpG site, CpGs whose DNA methylation levels correlate with age. The first robust demonstration that DNA methylation levels in saliva could generate age predictors with an average accuracy of 5.2 years was published by a UCLA team including Sven Bocklandt, Steve Horvath, and Eric Vilain in 2011 (Bocklandt et al. 2011). The laboratories of Trey Ideker and Kang Zhang at the University of California, San Diego published the Hannum epigenetic clock (Hannum 2013), which consisted of 71 markers that accurate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. Such effects on cellular and physiological traits may result from environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Further, non-coding RNA sequences have been shown to play a key role in the r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apolipoprotein E
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. It is encoded in humans by the gene ''APOE''. Apo-E belongs to a family of fat-binding proteins called apolipoproteins. In the circulation, it is present as part of several classes of lipoprotein particles, including chylomicron remnants, VLDL, IDL, and some HDL. Apo-E interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing (catabolism) of triglyceride-rich lipoproteins. In peripheral tissues, Apo-E is primarily produced by the liver and macrophages, and mediates cholesterol metabolism. In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons via Apo-E receptors, which are members of the low density lipoprotein receptor gene family. Apo-E is the principal cholesterol carrier in the brain. Apo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
