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Artificial Ligament
Artificial ligaments are devices used to replace damaged ligaments. Today, the most common use of artificial ligaments is in anterior cruciate ligament reconstruction. Although autotransplantation remains the most common method of ligament reconstruction, numerous materials and structures were developed to optimize the artificial ligament since its creation in the World War I era. Many modern artificial ligaments are made of synthetic polymers, such as polyethylene terephthalate. Various coatings have been added to improve the biocompatibility of the synthetic polymers. Early artificial ligaments developed in the 1980s were ineffective due to material deterioration. Currently, the Ligament Advanced Reinforcement System (LARS) artificial ligament has been utilized extensively in clinical applications. Tissue engineering is a growing area of research which aims to regenerate and restore ligament function. History Artificial ligament research began in the World War I era. In the fir ...
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Ligament
A ligament is a type of fibrous connective tissue in the body that connects bones to other bones. It also connects flight feathers to bones, in dinosaurs and birds. All 30,000 species of amniotes (land animals with internal bones) have ligaments. It is also known as ''articular ligament'', ''articular larua'', ''fibrous ligament'', or ''true ligament''. Comparative anatomy Ligaments are similar to tendons and fasciae as they are all made of connective tissue. The differences among them are in the connections that they make: ligaments connect one bone to another bone, tendons connect muscle to bone, and fasciae connect muscles to other muscles. These are all found in the skeletal system of the human body. Ligaments cannot usually be regenerated naturally; however, there are periodontal ligament stem cells located near the periodontal ligament which are involved in the adult regeneration of periodontist ligament. The study of ligaments is known as . Humans Other ligame ...
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Inflammation
Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', ''dolor'', ''rubor'', ''tumor'', and ''functio laesa''). Inflammation is a generic response, and therefore is considered a mechanism of innate immunity, whereas adaptive immunity is specific to each pathogen. Inflammation is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out damaged cells and tissues, and initiate tissue repair. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. However inflammation can also have negative effects. Too much inflammation, in the form of chronic inflammation, is associated with variou ...
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Polytetrafluoroethylene
Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer of tetrafluoroethylene, and has numerous applications because it is chemically inert. The commonly known brand name of PTFE-based composition is Teflon by Chemours, a corporate spin-off, spin-off from DuPont (1802–2017), DuPont, which originally invented the compound in 1938. Polytetrafluoroethylene is a fluorocarbon solid, as it is a high-molecular-weight polymer consisting wholly of carbon and fluorine. PTFE is hydrophobic: neither water nor water-containing substances Wetting, wet PTFE, as fluorocarbons exhibit only small London dispersion forces due to the low polarizability, electric polarizability of fluorine. PTFE has one of the lowest Friction#Coefficient of friction, coefficients of friction of any solid. Polytetrafluoroethylene is used as a non-stick coating for Cookware and bakeware, pans and other Cookware and bakeware, cookware. It is Chemically inert, non-reactive, partly because of the strength of car ...
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Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament reconstruction (ACL reconstruction) is a surgical tissue graft replacement of the anterior cruciate ligament, located in the knee, to restore its function after an injury. The torn ligament can either be removed from the knee (most common), or preserved (where the graft is passed inside the preserved ruptured native ligament) before reconstruction through an arthroscopic procedure. Background The Anterior Cruciate Ligament is the ligament that keeps the knee stable. Anterior Cruciate Ligament damage is a very common injury, especially among athletes. Anterior Cruciate Ligament Reconstruction (ACL) surgery is a common intervention. 1 in every 3,000 American ruptures their ACL and between 100,000 and 300,000 reconstruction surgeries will be performed each year in the United States. Around $500 million health care dollar will come from ACL injuries. ACL injuries can be categorized into groups- contact and non-contact based on the nature of the injury Co ...
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Poly(sodium Styrene Sulfonate)
Polystyrene sulfonates are a group of medications used to treat high blood potassium. Effects generally take hours to days. They are also used to remove potassium, calcium, and sodium from solutions in technical applications. Common side effects include loss of appetite, gastrointestinal upset, constipation, and low blood calcium. These polymers are derived from polystyrene by the addition of sulfonate functional groups. Sodium polystyrene sulfonate was approved for medical use in the United States in 1958. A polystyrene sulfonate was developed in the 2000s to treat '' Clostridioides difficile'' associated diarrhea under the name Tolevamer, but it was never marketed. Medical uses Polystyrene sulfonate is usually supplied in either the sodium or calcium form. It is used as a potassium binder in acute and chronic kidney disease for people with hyperkalemia (an abnormally high blood serum potassium level). However, it is unclear if it is beneficial and there is concern abou ...
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Chitosan
Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and ''N''-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, such as sodium hydroxide. Chitosan has a number of commercial and possible biomedical uses. It can be used in agriculture as a seed treatment and biopesticide, helping plants to fight off fungal infections. In winemaking, it can be used as a fining agent, also helping to prevent spoilage. In industry, it can be used in a self-healing polyurethane paint coating. In medicine, it is useful in bandages to reduce bleeding and as an antibacterial agent; it can also be used to help deliver drugs through the skin. History In 1799, British chemist Charles Hatchett experimented with decalcifying the shells of various crustaceans, finding that a soft, yellow and cartilage-like substance was left behind that ...
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Hyaluronic Acid
Hyaluronic acid (; abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about per molecule, or about 20,000 disaccharide monomers, while other sources mention . Medically, hyaluronic acid is used to treat osteoarthritis of the knee and dry eye, for wound repair, and as a cosmetic filler. The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one third of which is turned over (i.e., degraded and synthesized) per day. As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and is involved in the progression of many malignant tumors. Hyaluronic acid is also a ...
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Hydroxyapatite
Hydroxyapatite (International Mineralogical Association, IMA name: hydroxylapatite) (Hap, HAp, or HA) is a naturally occurring mineral form of calcium apatite with the Chemical formula, formula , often written to denote that the Crystal structure, crystal unit cell comprises two entities. It is the Hydroxy group, hydroxyl endmember of the complex apatite, apatite group. The ion can be replaced by fluorine, fluoride or chlorine, chloride, producing fluorapatite or chlorapatite. It crystallizes in the hexagonal (crystal system), hexagonal crystal system. Pure hydroxyapatite powder is white. Naturally occurring apatites can, however, also have brown, yellow, or green colorations, comparable to the discolorations of dental fluorosis. Up to 50% by volume and 70% by weight of human bone is a modified form of hydroxyapatite, known as bone mineral. Carbonated calcium-deficient hydroxyapatite is the main mineral of which dental enamel and dentin are composed. Hydroxyapatite crystals a ...
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PET Hyaluronic Acid Tissue
A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive/cute appearances, intelligence, and relatable personalities, but some pets may be taken in on an altruistic basis (such as a stray animal) and accepted by the owner regardless of these characteristics. Two of the most popular pets are dogs and cats. Other animals commonly kept include rabbits; ferrets; pigs; rodents such as gerbils, hamsters, chinchillas, rats, mice, and guinea pigs; birds such as parrots, passerines, and fowls; reptiles such as turtles, lizards, snakes, and iguanas; aquatic pets such as fish, freshwater snails, and saltwater snails; amphibians such as frogs and salamanders; and arthropod pets such as tarantulas and hermit crabs. Smaller pets include rodents, while the equine and bovine group include the largest companion animals. Pets provide ...
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Tensile Strength
Ultimate tensile strength (also called UTS, tensile strength, TS, ultimate strength or F_\text in notation) is the maximum stress that a material can withstand while being stretched or pulled before breaking. In brittle materials, the ultimate tensile strength is close to the yield point, whereas in ductile materials, the ultimate tensile strength can be higher. The ultimate tensile strength is usually found by performing a tensile test and recording the engineering stress versus strain. The highest point of the stress–strain curve is the ultimate tensile strength and has units of stress. The equivalent point for the case of compression, instead of tension, is called the compressive strength. Tensile strengths are rarely of any consequence in the design of ductile members, but they are important with brittle members. They are tabulated for common materials such as alloys, composite materials, ceramics, plastics, and wood. Definition The ultimate tensile strength ...
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LARS Artificial Ligament
Lars is a common male name in Scandinavian countries. Origin ''Lars'' means "from the city of Laurentum". Lars is derived from the Latin name Laurentius, which means "from Laurentum" or "crowned with laurel", and is therefore related to the name Laurence and Lauren. A homonymous Etruscan name was borne by several Etruscan kings, and later used as a last name by the Roman Lartia family. The etymology of the Etruscan name is unknown. Notable people *, bishop of Linköping (1236–1258) *, bishop of Linköping (1292–1307) *Lars (archbishop of Uppsala) (1255–1267) *Lars Kristian Abrahamsen (1855–1921), Norwegian politician *Lars Ahlfors (1907–1996), Finnish Fields Medal recipient *Lars Amble (1939–2015), Swedish actor and director *Lars Herminius Aquilinus, ancient Roman consul *Lars Bak (born 1980), Danish road bicycle racer *Lars Bak (computer programmer) (born 1965), Danish computer programmer *Lars Beckman (born 1967), Swedish politician *Lars Bender (born 1989), Germ ...
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Polypropylene
Polypropylene (PP), also known as polypropene, is a thermoplastic polymer used in a wide variety of applications. It is produced via chain-growth polymerization from the monomer Propene, propylene. Polypropylene belongs to the group of polyolefins and is Crystallization of polymers#Degree of crystallinity, partially crystalline and Chemical polarity#Nonpolar molecules, non-polar. Its properties are similar to polyethylene, but it is slightly harder and more heat-resistant. It is a white, mechanically rugged material and has a high chemical resistance. Polypropylene is the second-most widely produced Commodity plastics, commodity plastic (after polyethylene). History Phillips Petroleum chemists J. Paul Hogan and Robert Banks (chemist), Robert Banks first demonstrated the polymerization of propylene in 1951. The stereoselective polymerization to the isotactic was discovered by Giulio Natta and Karl Rehn in March 1954. This pioneering discovery led to large-scale commercial producti ...
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