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Arecaidine
Arecaidine is a bio-active alkaloid in areca nuts. It is a competitive GABA reuptake inhibitor. Lime is said to hydrolyse arecoline to arecaidine References {{GABA metabolism and transport modulators Piperidine alkaloids Beta-Amino acids GABA reuptake inhibitors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arecoline
Arecoline is a cholinergic agent, stimulant, and natural product, naturally occurring alkaloid found in areca nut, areca (betel) nuts of the areca palm (''Areca catechu'') found in South Asia, South and Southeast Asia. Its effects, depending on the dose, include stimulation, alertness, increased concentration, nootropic, cognitive enhancement, mood lift, elation, euphoriant, euphoria, aphrodisiac, pro-sexual effects, mental relaxation, relaxation, anxiolytic, reduced anxiety, and sedation, as well as drug addiction, addiction and drug withdrawal, withdrawal symptoms upon drug discontinuation, discontinuation. Its effects are described as subtle and it has been likened to a strong cup of coffee. There are also active constituents of areca nuts, but arecoline is the key active component, with a percentage of ~0.3 to 0.6%. Areca nuts are drug administration, administered by chewing for 5 to 20minutes without swallowing. Side effects of arecoline include hypersalivation, hypotensio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GABA Reuptake Inhibitor
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. Gamma-aminobutyric acid (GABA) is an amino acid that functions as the predominant inhibitory neurotransmitter within the central nervous system, playing a crucial role in modulating neuronal activity in both the brain and spinal cord. While GABA predominantly exerts inhibitory actions in the adult brain, it has an excitatory role during developmental stages. When the neuron receives the action potential, GABA is released from the pre-synaptic cell to the synaptic cleft. After the action potential transmission, GABA is detected on the dendritic side, where specific receptors collectively contribute to the inhibitory outcome by facilitating GA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large variety of organisms including bacteria, fungus, fungi, Medicinal plant, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. Alkaloids have a wide range of pharmacology, pharmacological activities including antimalarial medication, antimalarial (e.g. quinine), asthma, antiasthma (e.g. ephedrine), chemotherapy, anticancer (e.g. omacetaxine mepesuccinate, homoharringtonine), cholinomimetic (e.g. galantamine), vasodilation, vasodilatory (e.g. vincamine), Antiarrhythmic agent, antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and anti-diabetic, antihyperglycemic activities (e.g. berb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Areca Nut
The areca nut ( or ) or betel nut () is the fruit of the areca palm (''Areca catechu''). The palm is originally native to the Philippines, but was carried widely through the tropics by the Austronesian migrations and trade since at least 1500 BCE due to its use in betel nut chewing. It is widespread in cultivation and is considered naturalized in much of the tropical Pacific (Melanesia and Micronesia), South Asia, Southeast Asia, and parts of east Africa. It is not to be confused with betel (''Piper betle'') leaves that are often used to wrap it. The practice of betel nut chewing, often together with other herbs as a stimulant drug, dates back thousands of years, and continues to the present day in many countries. Betel nut chewing is addictive due to the presence of the stimulant arecoline, and causes adverse health effects, mainly oral and esophageal cancers, and cardiovascular disease. When chewed with additional tobacco in its preparation (like in gutka), there is an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Piperidine Alkaloids
Piperidine alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from piperidine. Alkaloids with a piperidine building block are widespread and are usually further subdivided according to their occurrence and biogenetic origin. The most important representative of piperidine alkaloids is piperine, which is responsible for the pungent taste of pepper. The piperidine alkaloids also include the sedum alkaloids (e.g. sedamine), pelletierine, the lobelia alkaloids (e.g. lobeline), the conium alkaloids (such as coniine) and the pinus alkaloids. Piperin.svg, Piperine Lobeline Structural Formula V2.svg, Lobeline Lobeline is a piperidine alkaloid found in a variety of plants, particularly those in the genus '' Lobelia'', including Indian tobacco ('' Lobelia inflata''), Devil's tobacco ('' Lobelia tupa''), great lobelia ('' Lobelia siphilitica''), '' Lobe ... (S)-Coniine Structural Formula V.1.svg, (''S'')-Coniine (2R, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
