Arbaclofen Placarbil
Arbaclofen placarbil ( , also known as XP19986) is a prodrug of ''R''- baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelinthe insulating covers of nerve cellsin the brain and spinal cord. As a demyelinating disease, MS disrupts the nervous system's ability to Action potential, transmit ...; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials. It is being developed as an addiction medicine to treat alcoholism. It is also studied as a potential therapeutic for some autistic subjects. See also * Gabapentin enacarbil * Lesogaberan References Abandoned drugs Calcium channel blockers 4-Chlorophenyl compoun ...
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