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Antabuse Effect
Disulfiram-alcohol reaction (DAR) is the effect of the interaction in the human body of alcohol drunk with disulfiram or some types of mushrooms. The DAR is key to disulfiram therapy that is widely used for alcohol-aversive treatment and management of other addictions (e.g. cocaine use). Once disulfiram-treated patients take Alcoholic beverage, alcohol, even in small doses, they experience strong unpleasant sensations (alcohol flush reaction, flush, nausea, lightheadedness, headache, sweating, vomiting, and vertigo). Disulfiram has been used to treat alcoholism since 1948 after its accidental discovery in Denmark. Pharmacology DAR symptoms usually begin within 5–15 minutes of the ingestion of alcohol by a patient who has taken disulfiram 3–12 hours before. Increased acetaldehyde content in blood is considered to be the cause of the toxic effect. Disulfiram inhibits several human aldehyde dehydrogenases (ALDH), most importantly the version coded for by gene ALDH2 which met ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicology
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia. The word ''toxicology'' () ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ALDH2
Aldehyde dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ''ALDH2'' gene located on chromosome 12. ALDH2 belongs to the aldehyde dehydrogenase family of enzymes. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2 has a low Km for acetaldehyde, and is localized in mitochondrial matrix. The other liver isozyme, ALDH1, localizes to the cytosol. Most White people have both major isozymes, while approximately 36% of East Asians have the cytosolic isozyme but not a functional mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Whites could be related to this absence of a catalytically active form of ALDH2. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. Gene The ''ALDH2'' gene is about 44 kbp in length and contains at least 13 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mushroom Poisoning
Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxicity, toxic substances. Signs and symptoms, Symptoms can vary from slight Gastrointestinal tract, gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by the fungus. Mushroom poisoning is usually the result of ingestion of wild mushrooms after misidentification of a Mycotoxin, toxic mushroom as an edible species. The most common reason for this misidentification is a close resemblance in terms of color and general Morphology (biology), morphology of the toxic mushrooms species with edible species. To prevent mushroom poisoning, mushroom gatherers familiarize themselves with the mushrooms they intend to collect, as well as with any similar-looking toxic species. The safety of eating wild mushrooms may depend on methods of preparation for cooking. Some toxins, such as amatoxins, are Thermostability, thermostable and mushrooms containing such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disulfiram-like Drug
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others. These effects are caused by accumulation of acetaldehyde, a major but toxic metabolite of alcohol formed by the enzyme alcohol dehydrogenase. The reaction has been variously termed a ''disulfiram-like reaction'', ''alcohol intolerance'', and ''acetaldehyde syndrome''.Mutalik, M., & Sanghavi, D. (2014). ''Review of Drug Interactions: A Comprehensive Update''. The prototypical drug of this group is disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor, preventing the metabolism of acetaldehyde into acetic acid, and is used in the treatment of alcoholism. A variety of other drugs cause disulfiram-like reactions upon consumption of alcohol as unintended drug interactions and side effects. Many disulfiram-like drugs act as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcohol Intolerance
Alcohol intolerance is due to a Gene polymorphism, genetic polymorphism of the aldehyde dehydrogenase enzyme, which is responsible for the metabolism of acetaldehyde (produced from the metabolism of alcohol (drug), alcohol by alcohol dehydrogenase). This polymorphism is most often reported in patients of East Asian descent. Alcohol intolerance may also be an associated side effect of certain drugs such as disulfiram, metronidazole, or nilutamide. Skin flushing and nasal congestion are the most common symptoms of intolerance after Drinking alcohol, alcohol ingestion. It may also be characterized as Drug intolerance, intolerance causing Hangover#Acetaldehyde, hangover symptoms similar to the "disulfiram-like reaction" of Aldehyde dehydrogenase#Pathology (aldehyde dehydrogenase deficiency), aldehyde dehydrogenase deficiency or chronic fatigue syndrome. Severe pain after drinking alcohol may indicate a more serious underlying condition. Drinking alcohol in addition to consuming calcium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
