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Amixetrine
Amixetrine (INN; brand name Somagest; developmental code CERM-898) is a drug that was formerly marketed in France but is now no longer sold. According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of serotonin and serotonergic drugs at serotonin (5-HT) receptors. Types 5-HT2A antagonists Antagonists of the 5-HT2A receptor are sometimes used ..., but its definitive indications and pharmacology are unclear. The drug was first synthesized in 1969 and was introduced in France in 1972. Synthesis The treatment of isoamyl alcohol (1) with styrene (2) at -10 °C with dropwise addition of ''tert''-butyl hypobromite gives (2-bromo-1-(isopentyloxy)ethyl)benzene (3). Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4). References {{refli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amixetrine Synthesis
Amixetrine (International Nonproprietary Name, INN; brand name Somagest; developmental code CERM-898) is a drug that was formerly marketed in France but is now no longer sold. According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear. The drug was first synthesized in 1969 and was introduced in France in 1972. Synthesis The treatment of isoamyl alcohol (1) with styrene (2) at -10 °C with dropwise addition of ''tert''-butyl hypobromite gives (2-bromo-1-(isopentyloxy)ethyl)benzene (3). Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4). References {{reflist Abandoned drugs Anti-inflammatory agents Antidepressants Antispasmodics Drugs with unknown mechanisms of action Phenylethanolamine ethers 1-Pyrrolidinyl compounds Isopentyl compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
