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Albrecht Kossel
Ludwig Karl Martin Leonhard Albrecht Kossel (; 16 September 1853 – 5 July 1927) was a biochemist and pioneer in the study of genetics. He was awarded the Nobel Prize for Physiology or Medicine in 1910 for his work in determining the chemical composition of nucleic acids, the genetic substance of biological cells. Kossel isolated and described the five organic compounds that are present in nucleic acid: adenine, cytosine, guanine, thymine, and uracil. These compounds were later shown to be nucleobases, and are key in the formation of DNA and RNA, the genetic material found in all living cells. Kossel was an important influence on and collaborator with other important researchers in biochemistry, including Henry Drysdale Dakin, Friedrich Miescher, Edwin B. Hart, and his professor and mentor, Felix Hoppe-Seyler. Kossel was editor of the Zeitschrift für Physiologische Chemie (Journal of Physiological Chemistry) from 1895 until his death. Kossel also conducted important ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Rostock
The University of Rostock () is a public university located in Rostock, Mecklenburg-Vorpommern, Germany. Founded in 1419, it is the third-oldest university in Germany. It is the oldest university in continental northern Europe and the Baltic Sea area, and 8th oldest in Central Europe. It was the 5th university established in the Holy Roman Empire. The university has been associated with three Nobel laureates: Albrecht Kossel, Karl von Frisch and Otto Stern. It is a member of the European University Association. According to a ranking published by ''Times Higher Education'' in 2018, it is the most beautiful university in Germany and the fourth most beautiful university in all of Europe. The language of instruction is usually German, and English for some postgraduate studies. History 1419–1919 The university was founded in 1419 by confirmation of Pope Martin V and thus is one of the oldest universities in Northern Europe. In Germany, there are only five universities that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rostock
Rostock (; Polabian language, Polabian: ''Roztoc''), officially the Hanseatic and University City of Rostock (), is the largest city in the German States of Germany, state of Mecklenburg-Vorpommern and lies in the Mecklenburgian part of the state, close to the border with Pomerania. With around 210,000 inhabitants, it is the third-largest city on the German Baltic Sea, Baltic coast after Kiel and Lübeck, the eighth-largest city in the area of former East Germany, as well as the List of cities in Germany by population, 39th-largest city of Germany. Rostock was the largest coastal and most important port city in East Germany. Rostock stands on the estuary of the Warnow, River Warnow into the Bay of Mecklenburg of the Baltic Sea. The city stretches for about along the river. The river flows into the sea in the very north of the city, between the boroughs of Warnemünde and Hohe Düne. The city center lies further upstream, in the very south of the city. Most of Rostock's inhabita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (biology)
The cell is the basic structural and functional unit of all life, forms of life. Every cell consists of cytoplasm enclosed within a Cell membrane, membrane; many cells contain organelles, each with a specific function. The term comes from the Latin word meaning 'small room'. Most cells are only visible under a light microscope, microscope. Cells Abiogenesis, emerged on Earth about 4 billion years ago. All cells are capable of Self-replication, replication, protein synthesis, and cell motility, motility. Cells are broadly categorized into two types: eukaryotic cells, which possess a Cell nucleus, nucleus, and prokaryotic, prokaryotic cells, which lack a nucleus but have a nucleoid region. Prokaryotes are single-celled organisms such as bacteria, whereas eukaryotes can be either single-celled, such as amoebae, or multicellular organism, multicellular, such as some algae, plants, animals, and fungi. Eukaryotic cells contain organelles including Mitochondrion, mitochondria, which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albrecht Kossel Institute For Neuroregeneration
The Albrecht Kossel Institute for Neuroregeneration is a medical research hospital located in Rostock, Germany. It was formed from the neurobiological laboratory of the hospital for neurology at the University of Rostock, and it operates under the auspices of The University Clinic of Rostock. The institute conducts research into rare congenital metabolic illnesses such as Fabry's disease and Gaucher's disease. It enjoys worldwide recognition as a diagnostic and treatment center for rare illnesses. Its stated area of research is ''neuroregeneration'', the regrowth or repair of nervous tissues and cells. The institute is named for Albrecht Kossel, noted German biochemist, 1910 Nobel laureate in Physiology or Medicine, and graduate of the university. Sifap In 2007, the Institute initiated Sifap, a Pan-European study dedicated to investigating the correlation of juvenile stroke and a genetic disorder known as Fabry's disease. The institute will engage in professional cooperation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polypeptide
Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. Peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic peptides have an N-terminal (amine group) and C-terminal (ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Chemistry (journal)
''Biological Chemistry'' is a Peer review, peer-reviewed scientific journal focusing on biological chemistry. The journal is published by Walter de Gruyter and the current editor-in-chief is Bernhard Brüne. History The journal was established by Felix Hoppe-Seyler in 1877, under the name ''Zeitschrift für Physiologische Chemie'' (English: ''Journal of Physiological Chemistry''), and was edited by him until his death in 1895. The journal was subsequently renamed '' Hoppe-Seyler's Zeitschrift für Physiologische Chemie'' in 1896. Following Hoppe-Seyler, the journal was edited by his student and collaborator, the German biochemist and Nobel Prize in Physiology or Medicine, Nobel laureate Albrecht Kossel, until his death in 1927. In 1985 the journal was renamed as ''Biological Chemistry Hoppe-Seyler'', before obtaining its current title in 1996. Abstracting and indexing ''Biological Chemistry'' is abstracted and indexed in: According to the ''Journal Citation Reports'', the jou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Felix Hoppe-Seyler
Ernst Felix Immanuel Hoppe-Seyler (''né'' Felix Hoppe; 26 December 1825 – 10 August 1895) was a German physiologist and chemist, and the principal founder of the disciplines of biochemistry and molecular biology. He had discovered Yeast nucleic acid which is now called RNA in his attempts to follow up and confirm Miescher's results by repeating parts of Miescher's experiments. He took the name Hoppe-Seyler family, Seyler when he was adopted by his brother-in-law, a grandson of the famous theatre principal Abel Seyler. Biography Hoppe-Seyler was born in Freyburg, Germany, Freyburg an der Unstrut in the Province of Saxony. He originally trained to be a physician in University of Halle-Wittenberg, Halle and University of Leipzig, Leipzig, and received his medical doctorate from Humboldt University of Berlin, Berlin in 1851. Afterwards, he was an assistant to Rudolf Virchow at the pathology, Pathological Institute in Berlin. Hoppe-Seyler preferred scientific research to medicine, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Friedrich Miescher
Johannes Friedrich Miescher (13 August 1844 – 26 August 1895) was a Swiss physician and biologist. He was the first scientist to isolate nucleic acid in 1869. Miescher also identified protamine and made several other discoveries. Miescher had isolated various phosphate-rich chemicals, which he called ''nuclein'' (now nucleic acids), from the nuclei of white blood cells in Felix Hoppe-Seyler's laboratory at the University of Tübingen, Germany, paving the way for the identification of DNA as the carrier of inheritance. The significance of the discovery, first published in 1871, was not at first apparent, and Albrecht Kossel made the initial inquiries into its chemical structure. Later, Miescher raised the idea that the nucleic acids could be involved in heredity and even posited that there might be something akin to an alphabet that might explain how variation is produced. Early life and education Friedrich Miescher came from a scientific family; his father and his uncle he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Henry Drysdale Dakin
Henry Drysdale Dakin Fellow of the Royal Society, FRS (12 March 188010 February 1952) was an England, English chemist. He was born in London as the youngest of 8 children to a family of steel merchants from Leeds. As a school boy, he conducted water analysis with the Leeds City Analyst. He was taught chemistry by Julius B. Cohen at the University of Leeds, and then he worked with Albrecht Kossel on arginase at the University of Heidelberg. He joined Columbia University in 1905, working in the lab of Christian Archibald Herter (physician), Christian Herter. During his work on amino acids he obtained his PhD from Leeds. In 1905, he was one of the first scientists to successfully synthesise adrenaline in the laboratory (see: History of catecholamine research). In 1914 he went back to England to offer his service with the war effort. Due to a request for a chemist by Alexis Carrel to the Rockefeller Institute, Dakin joined Carrel in 1916 at a temporary hospital in Compiègne. There ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uracil
Uracil () (nucleoside#List of nucleosides and corresponding nucleobases, symbol U or Ura) is one of the four nucleotide bases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine (T). Uracil is a demethylated form of thymine. Uracil is a common and naturally occurring pyrimidine derivative. The name "uracil" was coined in 1885 by the German chemist Robert Behrend, who was attempting to synthesize derivatives of uric acid. Originally discovered in 1900 by Alberto Ascoli, it was isolated by hydrolysis of yeast nuclein; it was also found in bovine thymus and spleen, herring sperm, and wheat Cereal germ, germ. It is a planar, unsaturated compound that has the ability to absorb light. Uracil that was formed extraterrestrially has been detected in the Murchison meteorite, in near-Earth asteroid 162173 Ryugu, Ryugu, and possibly on the surface of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thymine
Thymine () (symbol T or Thy) is one of the four nucleotide bases in the nucleic acid of DNA that are represented by the letters G–C–A–T. The others are adenine, guanine, and cytosine. Thymine is also known as 5-methyluracil, a pyrimidine nucleobase. In RNA, thymine is replaced by the nucleobase uracil. Thymine was first isolated in 1893 by Albrecht Kossel and Albert Neumann from calf thymus glands, hence its name. Derivation As its alternate name (5-methyluracil) suggests, thymine may be derived by methylation of uracil at the 5th carbon. In RNA, thymine is replaced with uracil in most cases. In DNA, thymine (T) binds to adenine (A) via two hydrogen bonds, thereby stabilizing the nucleic acid structures. Thymine combined with deoxyribose creates the nucleoside deoxythymidine, which is synonymous with the term thymidine. Thymidine can be phosphorylated with up to three phosphoric acid groups, producing dTMP (deoxythymidine monophosphate), dTDP, or dTTP (for the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
