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Albrecht Fleckenstein
Albrecht Fleckenstein (3 March 1917 – 4 April 1992) was a German pharmacologist and physiologist best known for his discovery of calcium channel blockers. Life and career Albrecht Fleckenstein was born on 3 March 1917 in Aschaffenburg, Germany. He received his medical training in Würzburg and Vienna. In 1964, Fleckenstein reported on the inhibitory actions of prenylamine and verapamil on the physiological process of excitation–contraction coupling. This contributed to his discovery of calcium antagonists. Awards In 1986, Fleckenstein received the Ernst Jung Prize, awarded annually for excellence in biomedical sciences Biomedical sciences are a set of sciences applying portions of natural science or formal science, or both, to develop knowledge, interventions, or technology that are of use in healthcare or public health. Such disciplines as medical microbio .... In 1991, he also received the Albert Einstein World Award of Science. References {{DEFAUL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcium Antagonist
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension. CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients. Calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. N-type, L-type, and T-type voltage-dependent calcium channels are present in the zona glomerulosa of the human adrenal gland, and CCBs can directly influence the biosynthesis of aldosterone in adrenocortical cells, with consequent impact on the clinical treatment of hypertension with these agents. CCBs have been sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1992 Deaths
Year 199 ( CXCIX) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was sometimes known as year 952 ''Ab urbe condita''. The denomination 199 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Mesopotamia is partitioned into two Roman provinces divided by the Euphrates, Mesopotamia and Osroene. * Emperor Septimius Severus lays siege to the city-state Hatra in Central-Mesopotamia, but fails to capture the city despite breaching the walls. * Two new legions, I Parthica and III Parthica, are formed as a permanent garrison. China * Battle of Yijing: Chinese warlord Yuan Shao defeats Gongsun Zan. Korea * Geodeung succeeds Suro of Geumgwan Gaya, as king of the Korean kingdom of Gaya (traditional date). By topic Religion * Pope Zephyrinus succeeds Pope Vic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1917 Births
Events Below, the events of World War I have the "WWI" prefix. January * January 9 – WWI – Battle of Rafa: The last substantial Ottoman Army garrison on the Sinai Peninsula is captured by the Egyptian Expeditionary Force's Desert Column. * January 10 – Imperial Trans-Antarctic Expedition: Seven survivors of the Ross Sea party were rescued after being stranded for several months. * January 11 – Unknown saboteurs set off the Kingsland Explosion at Kingsland (modern-day Lyndhurst, New Jersey), one of the events leading to United States involvement in WWI. * January 16 – The Virgin Islands, Danish West Indies is sold to the United States for $25 million. * January 22 – WWI: United States President Woodrow Wilson calls for "peace without victory" in Germany. * January 25 ** WWI: British armed merchantman is sunk by mines off Lough Swilly (Ireland), with the loss of 354 of the 475 aboard. ** An anti-prostitution drive in Prostitution in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Physiologists
German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Germanic peoples (Roman times) * German language **any of the Germanic languages * German cuisine, traditional foods of Germany People * German (given name) * German (surname) * Germán, a Spanish name Places * German (parish), Isle of Man * German, Albania, or Gërmej * German, Bulgaria * German, Iran * German, North Macedonia * German, New York, U.S. * Agios Germanos, Greece Other uses * German (mythology), a South Slavic mythological being * Germans (band), a Canadian rock band * "German" (song), a 2019 song by No Money Enterprise * ''The German'', a 2008 short film * "The Germans", an episode of ''Fawlty Towers'' * ''The German'', a nickname for Congolese rebel André Kisase Ngandu See also * Germanic (other) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Einstein World Award Of Science
The Albert Einstein World Award for Science is an annual award given by the World Cultural Council "as a means of recognition and encouragement for scientific and technological research and development", with special consideration for researches which "have brought true benefit and well being to mankind". Named for physicist and theoretician Albert Einstein (1879–1955); the award includes a diploma, a commemorative medal, and US$10,000. The recipient of the award is evaluated and elected by an Interdisciplinary Committee, which is composed of world-renowned scientists, among them 25 Nobel laureates. Award recipients See also * Leonardo da Vinci World Award of Arts * José Vasconcelos World Award of Education * Albert Einstein Medal * Albert Einstein Award * Prizes named after people * List of things named after Albert Einstein * List of physics awards * List of general science and technology awards This list of general science and technology awards is an index to a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedical Sciences
Biomedical sciences are a set of sciences applying portions of natural science or formal science, or both, to develop knowledge, interventions, or technology that are of use in healthcare or public health. Such disciplines as medical microbiology, clinical virology, clinical epidemiology, genetic epidemiology, and biomedical engineering are medical sciences. In explaining physiological mechanisms operating in pathological processes, however, pathophysiology can be regarded as basic science. Biomedical Sciences, as defined by the UK Quality Assurance Agency for Higher Education Benchmark Statement in 2015, includes those science disciplines whose primary focus is the biology of human health and disease and ranges from the generic study of biomedical sciences and human biology to more specialised subject areas such as pharmacology, human physiology and human nutrition. It is underpinned by relevant basic sciences including anatomy and physiology, cell biology, biochemi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Jung Prize
The Ernst Jung Prize is a prize awarded annually for excellence in biomedical sciences. The Ernst Jung Foundation, funded by Hamburg merchant Ernst Jung in 1967, has awarded the Ernst Jung Prize in Medicine, now €300,000, since 1976, and the lifetime achievement Ernst Jung Gold Medal for Medicine since 1990. Ernst Jung Prize for Medicine SourceJung Foundation *1976: Donald Henderson and Lorenz Zimmerman *1977: and John B. West *1979: Karl Lennert and *1980: , Alan Parks and *1981: David E. Kuhl *1982: Hartmut Wekerle and Rolf M. Zinkernagel *1983: and Richard Lower *1984: , Werner Franke and Klaus Weber *1985: Hendrik Coenraad Hemker, Rudolf Pichlmayr and Peter K. Vogt *1986: Albrecht Fleckenstein *1987: Peter Richardson and *1988: Helmut Sies and Charles Weissmann *1989: and Jon van Rood *1990: Gerhard Giebisch and *1991: David Ho and *1992: Roy Yorke Calne and *1993: Charles A. Dinarello and Robert Machemer *1994: and Wolf Singer *1995: Anthony Fauci and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Excitation–contraction Coupling
Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding something heavy in the same position. The termination of muscle contraction is followed by muscle relaxation, which is a return of the muscle fibers to their low tension-generating state. For the contractions to happen, the muscle cells must rely on the interaction of two types of filaments which are the thin and thick filaments. Thin filaments are two strands of actin coiled around each, and thick filaments consist of mostly elongated proteins called myosin. Together, these two filaments form myofibrils which are important organelles in the skeletal muscle system. Muscle contraction can also be described based on two variables: length and tension. A muscle contraction is described as isometric if the muscle tension changes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Verapamil
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be used for the prevention of migraines and cluster headaches. It is given by mouth or by injection into a vein. Common side effects include headache, low blood pressure, nausea, and constipation. Other side effects include allergic reactions and muscle pains. It is not recommended in people with a slow heart rate or heart failure. It is believed to cause problems for the fetus if used during pregnancy. It is in the non–dihydropyridine calcium channel blocker family of medications. Verapamil was approved for medical use in the United States in 1981. It is on the World Health Organization's List of Essential Medicines. Verapamil is available as a generic medication. Long acting formulations exist. In 2020, it was the 151st most ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
