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Alan P. Kozikowski
Alan P. Kozikowski is an American medicinal chemist, drug designer, and pharmaceutical entrepreneur, best known for his research on 5-HT receptors, and GSK-3 inhibitors. He is an author of a book ''Drug Design for Neuroscience''. He has over 100 patents, over 550 publications. Education and Postdoctoral research Kozikowski received a PhD in organic chemistry at the University of California, Berkeley. During his post-doctoral at Harvard University, he worked on organic synthesis under the supervision of Nobel laureate E.J. Corey. Research career Kozikowski began his career as an organic chemist at the University of Pittsburgh. Later, following his interest in the applications of chemistry to biological problems, he joined the Mayo Clinic, and drug discovery program at the Georgetown University Medical Center. During this period his team was the first to synthesize the naturally occurring alkaloid Huperzine A, an AChE inhibitor that has memory-enhancing properties, and may be us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicinal Chemist
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GSK3B
Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the ''GSK3B'' gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder. Function Glycogen synthase kinase-3 ( GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. It might be a new therapeutic target for ischemic stroke. Disease relevance Homozygous disruption of the Gsk3b locus in mice results in embryonic lethality during mid-gestation. This lethality phenotype could be rescued by inhibition of tumor necrosis factor. Two SNPs at this gene, rs334558 (-50T/C) and rs3755557 (-1727A/T), are ass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Illinois Faculty
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the Middl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georgetown University Medical Center Faculty
Georgetown or George Town may refer to: Places Africa *George, South Africa, formerly known as Georgetown * Janjanbureh, Gambia, formerly known as Georgetown *Georgetown, Ascension Island, main settlement of the British territory of Ascension Island Asia * Georgetown, Prayagraj, India * George Town, Chennai, India *George Town, Penang, capital city of the Malaysian state of Penang Europe * Georgetown, Blaenau Gwent, now part of the town of Tredegar in Wales * Georgetown, Dumfries and Galloway, a location in Dumfries and Galloway, Scotland * Es Castell in Minorca, Spain, originally called Georgetown North and Central America Canada * Georgetown, Alberta * Georgetown, Newfoundland and Labrador *Georgetown, Ontario * Georgetown, Prince Edward Island Caribbean * George Town, Bahamas, a village in Exuma District, Bahamas * George Town, Belize, a village in Stann Creek District, Belize *George Town, Cayman Islands, the capital city on Grand Cayman * Georgetown, Saint Vincent and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Berkeley Alumni
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Michigan Alumni
A university () is an educational institution, institution of tertiary education and research which awards academic degrees in several Discipline (academia), academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate education, undergraduate and postgraduate education, postgraduate programs. The first universities in Europe were established by Catholic Church, Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bright Minds Biosciences
Bright may refer to: Common meanings *Bright, an adjective meaning giving off or reflecting illumination; see Brightness *Bright, an adjective meaning someone with intelligence People * Bright (surname) * Bright (given name) *Bright, the stage name of Thai actor, musician, model, host and entrepreneur Vachirawit Chivaaree Places Australia * Bright, Victoria, a town * Electoral district of Bright in South Australia Canada * Bright Parish, New Brunswick Northern Ireland * Bright, County Down, a village and parish in County Down United States *Bright, Indiana, a census-designated place * Bright, West Virginia, an unincorporated community * Bright, Wisconsin, an unincorporated community Arts and entertainment Music * Bright (American band), an experimental pop group from Brooklyn, New York ** ''Bright'' (Bright (American band) album), 1996 album *Bright (Japanese band), a dance vocal band from Japan ** ''Bright'' (Bright (Japanese band) album), 2012 album * "Bright" (song), a so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HDAC6
Histone deacetylase 6 is an enzyme that in humans is encoded by the ''HDAC6'' gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit as a therapeutic strategy to combat several types of cancer and neurodegenerative disorders. Function Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. It retracts the cilium of the cell, which is necessary prior to mitosis. * HDAC encourages cell motility and catalyzes α-tubulin deacetylation. As a result the enzyme encourages cancer cell metastasis. HDAC6 affects transcription and tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
