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Adolfo García-Sastre
Adolfo García-Sastre,(born in Burgos, 10 October 1964) is a Spaniards, Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City. His research into the biology of Orthomyxoviridae, influenza viruses has been at the forefront of medical advances in epidemiology. García-Sastre is the author of more than 700 publications. Biography Born in Burgos, Spain, García-Sastre earned his PhD at the University of Salamanca. His research interest has been focused on the molecular biology of influenza viruses and several other Sense (molecular biology), negative-strand RNA viruses. His contributions to his field have included the generation and evaluation of influenza virus vectors as potential vaccine candidates against infectious diseases, including malaria and AIDS, as well as the development (with Peter Palese) of the first reverse-genetic approaches for the productio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burgos
Burgos () is a city in Spain located in the autonomous community of Castile and León. It is the capital and most populous municipality of the province of Burgos. Burgos is situated in the north of the Iberian Peninsula, on the confluence of the Arlanzón (river), Arlanzón river tributaries and at the edge of the Meseta Central, central plateau. The municipality has a population of about 180,000 inhabitants. The Camino de Santiago pilgrimage route runs through Burgos. Founded in 885 by the second Count of Castile, Diego Rodríguez Porcelos, Burgos soon became the leading city of the embryonic County of Castile. The 11th century chieftain El Cid, Rodrigo Díaz de Vivar (''El Cid'') had connections with the city: born near Burgos, he was raised and educated there. Burgos experienced a long decline from the 17th century onwards. Burgos became the headquarters of the Francoist proto-government (1936–1939) following the start of the Spanish Civil War. Declared in 1964 as Pole of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AIDS
The HIV, human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a Preventive healthcare, preventable disease. It can be managed with treatment and become a manageable chronic health condition. While there is no cure or vaccine for HIV, Management of HIV/AIDS, antiretroviral treatment can slow the course of the disease, and if used before significant disease progression, can extend the life expectancy of someone living with HIV to a nearly standard level. An HIV-positive person on treatment can expect to live a normal life, and die with the virus, not of it. Effective #Treatment, treatment for HIV-positive people (people living with HIV) involves a life-long regimen of medicine to suppress the virus, making the viral load undetectable. Treatment is recommended as soon as the diagnosis is made. An HIV-positive person who has an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of General Virology
''Journal of General Virology'' is a not-for-profit peer-reviewed scientific journal published by the Microbiology Society. The journal was established in 1967 and covers research into animal, insect and plants viruses, also fungal viruses, prokaryotic viruses, and TSE agents. Antiviral compounds and clinical aspects of virus infection are also covered. Since 2020 the editor-in-chief is Paul Duprex (Centre for Vaccine Research, University of Pittsburgh), who took over from Professor Mark Harris (University of Leeds) who had served as Editor-in-Chief since 2015. Journal Article types ''Journal of General Virology'' publishes primary research articles, Reviews, Short Communications, Personal Views, and Editorials. Since 2017 the journal has partnered with the International Committee on Taxonomy of Viruses to publish Open Access ICTV Virus Taxonomy Profiles which summarise chapters of the ICTV's 10th Report on Virus Taxonomy. All ICTV Virus Taxonomy Profiles are published und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virology (journal)
''Virology'' is a peer-reviewed scientific journal in virology. Established in 1955 by George Hirst, Lindsay Black and Salvador Luria, it is the earliest English-only journal to specialize in the field. The journal covers basic research into viruses affecting animals, plants, bacteria and fungi, including their molecular biology, structure, assembly, pathogenesis, immunity, interactions with the host cell, evolution and ecology. Molecular aspects of control and prevention are also covered, as well as viral vectors and gene therapy, but clinical virology is excluded. As of 2013, the journal is published fortnightly by Elsevier. History The field of virology began in the 1890s, with the discovery of infectious agents small enough to pass through filters sufficiently fine to catch bacteria. The first specialist journal in the field, '' Archiv für die gesamte Virusforschung'', appeared in 1939. Published by Springer-Verlag out of its Vienna office, its papers were in a mixture of l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Virology
The ''Journal of Virology'' is a biweekly peer-reviewed scientific journal that covers research concerning all aspects of virology. It was established in 1967 and is published by the American Society for Microbiology. Research papers are available free online 6 months after print publication. The current editors-in-chief are Felicia Goodrum (University of Arizona) and Stacey Schultz-Cherry ( St. Jude Children's Research Hospital). Past editors-in-chief include Rozanne M. Sandri-Goldin (University of California, Irvine, California) (2012-2022), Lynn W. Enquist (2002–2012), Thomas Shenk (1994–2002), and Arnold J. Levine (1984–1994).American Society for Microbiology: ASM Announces Appointments of New Editors In Chief for CMR and JVI [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLOS Pathogens
''PLOS Pathogens'' is a peer-reviewed open-access medical journal. All content in ''PLOS Pathogens'' is published under the Creative Commons "by-attribution" license. ''PLOS Pathogens'' began operation in September 2005. It was the fifth journal of the Public Library of Science (PLOS), a non-profit open-access publisher. Journal Scope The journal scope of ''PLOS Pathogens'' is to feature ''PLOS Pathogens'' publishes original research and commentary that significantly advance the understanding of pathogens and how they interact with their host organisms. Topics include (but are not limited to) adaptive and innate immune defenses as well as pathogen countermeasures, emerging pathogens, evolution, genomics and gene regulation, model host organisms, pathogen-cell biology, pathogenesis, prions, proteomics and signal transduction, rational vaccine design, structural biology, and virulence factors. Content ''PLOS Pathogens'' publishes primary research articles, Pearls, Research M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Experimental Medicine
''Journal of Experimental Medicine'' is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. Topics covered include immunology, inflammation, infectious disease, hematopoiesis, cancer, stem cells and vascular biology. The journal has no single editor-in-chief, but thirteen academic editors. History The journal was established in 1896 at the Johns Hopkins School of Medicine by William H. Welch, the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute (since renamed Rockefeller University). From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March 1902, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Allergy And Infectious Diseases
The National Institute of Allergy and Infectious Diseases (NIAID, ) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services. NIAID's mission is to conduct Basic research, basic and applied research to better understand, treat, and prevent Infectious disease, infectious, Immune disorder, immunologic, and Allergy, allergic diseases. NIAID has on-campus Laboratory, laboratories in Maryland and Hamilton, Montana, and funds research conducted by scientists at institutions in the United States and throughout the world. NIAID also works closely with partners in academia, industry, government, and non-governmental organizations in multifaceted and multidisciplinary efforts to address emerging health challenges such as the Pandemic H1N1/09 virus, H1N1/09 pandemic and the COVID-19 pandemic. History NIAID traces its origins to a small laboratory established in 1887 at the Marine H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morphology (biology)
Morphology (from Ancient Greek μορφή (morphḗ) "form", and λόγος (lógos) "word, study, research") is the study of the form and structure of organisms and their specific structural features. This includes aspects of the outward appearance (shape, structure, color, pattern, size), as well as the form and structure of internal parts like bones and organs, i.e., anatomy. This is in contrast to physiology, which deals primarily with function. Morphology is a branch of life science dealing with the study of the overall structure of an organism or taxon and its component parts. History The etymology of the word "morphology" is from the Ancient Greek (), meaning "form", and (), meaning "word, study, research". While the concept of form in biology, opposed to function, dates back to Aristotle (see Aristotle's biology), the field of morphology was developed by Johann Wolfgang von Goethe (1790) and independently by the German anatomist and physiologist Karl Fried ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M1 Protein
The M1 protein is a matrix protein of the influenza virus. It forms a coat inside the viral envelope. This is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously. The M1 protein binds to the viral RNA. The binding is not specific to any RNA sequence, and is performed via a peptide sequence rich in basic amino acids. It also has multiple regulatory functions, performed by interaction with the components of the host cell. The mechanisms regulated include a role in the export of the viral ribonucleoproteins from the host cell nucleus, inhibition of viral transcription, and a role in the virus assembly and budding. The protein was found to undergo phosphorylation in the host cell. The M1 protein forms a layer under the patches of host cell membrane that are rich with the viral hemagglutinin, neuraminidase and M2 transmembrane prot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections. However, virus-encoded genetic elements have the ability to antagonize the IFN response, contributing to viral pathogenesis and viral diseases. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility compl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NS1 Influenza Protein
The NS1 influenza protein (NS1) is a viral nonstructural protein encoded by the NS gene segments of type Influenza A virus, A, Influenza B, B and Influenza C virus, C influenza viruses. Also encoded by this segment is the nuclear export protein (NEP), formerly referred to as NS2 protein, which mediates the export of influenza virus ribonucleoprotein (RNP) complexes from the nucleus into the cytoplasm, where they are assembled.Influenza B and C Virus NEP (NS2) Proteins Possess Nuclear Export Activities Journal of Virology, August 2001, p. 7375-7383, Vol. 75, No. 16 Characteristics The NS1 of influenza A virus is a 26,000 Dalton protein. It prevents polyadenylation of cellular mRNAs to circumvent antiviral responses of th ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
