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Acetylaldehyde
Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula , sometimes abbreviated as . It is a colorless liquid or gas, boiling near room temperature. It is one of the most important aldehydes, occurring widely in nature and being produced on a large scale in industry. Acetaldehyde occurs naturally in coffee, bread, and ripe fruit, and is produced by plants. It is also produced by the partial oxidation of ethanol by the liver enzyme alcohol dehydrogenase and is a contributing cause of hangover after alcohol consumption. Pathways of exposure include air, water, land, or groundwater, as well as drink and smoke. Consumption of disulfiram inhibits acetaldehyde dehydrogenase, the enzyme responsible for the metabolism of acetaldehyde, thereby causing it to build up in the body. The International Agency for Research on Cancer (IARC) has listed acetaldehyde as a Group 1 carcinogen. Acetaldehyde is "one of the most frequently found air toxins with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Chemistry
The Royal Society of Chemistry (RSC) is a learned society and professional association in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Royal Institute of Chemistry, the Faraday Society, and the Society for Analytical Chemistry with a new Royal Charter and the dual role of learned society and professional body. At its inception, the Society had a combined membership of 49,000 in the world. The headquarters of the Society are at Burlington House, Piccadilly, London. It also has offices in Thomas Graham House in Cambridge (named after Thomas Graham (chemist), Thomas Graham, the first president of the Chemical Society) where ''RSC Publishing'' is based. The Society has offices in the United States, on the campuses of The University of Pennsylvania and Drexel University, at the University City Science Center in Philadelphia, Pennsylvania, in both Beijing and Shanghai, People' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methyl
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula ). In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, bonded to the rest of the molecule by a single covalent bond (), it can be found on its own in any of three forms: methanide anion (), methylium cation () or methyl radical (). The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed. Methyl cation, anion, and radical Methyl cation The methylium cation () exists in the gas phase, but is otherwise not encountered. Some compounds are considered to be sources of the cation, and this simplification is used pervasively in organic chemistry. For exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Justus Von Liebig
Justus ''Freiherr'' von Liebig (12 May 1803 – 18 April 1873) was a Germans, German scientist who made major contributions to the theory, practice, and pedagogy of chemistry, as well as to agricultural and biology, biological chemistry; he is considered one of the principal founders of organic chemistry. As a professor at the University of Giessen, he devised the modern laboratory-oriented teaching method, and for such innovations, he is regarded as one of the most outstanding chemistry teachers of all time. He has been described as the "father of the fertilizer industry" for his emphasis on nitrogen and minerals as essential plant nutrients, and his popularization of the law of the minimum, which states that plant growth is limited by the scarcest nutrient resource, rather than the total amount of resources available. He also developed a manufacturing process for Meat extract, beef extracts, and with his consent a company, called Liebig Extract of Meat Company, was founded to e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johann Wolfgang Döbereiner
Johann Wolfgang Döbereiner (13 December 1780 – 24 March 1849) was a German chemist who is known best for work that was suggestive of the periodic law for the chemical elements, and for inventing the first lighter, which was known as the Döbereiner's lamp. He became a professor of chemistry and pharmacy for the University of Jena. Life and work As a coachman's son, Döbereiner had little opportunity for formal schooling. Thus, he was apprenticed to an apothecary, and began to read widely and to attend science lectures. He eventually became a professor for the University of Jena in 1810 and also studied chemistry at Strasbourg. In work published during 1829, Döbereiner reported trends in certain properties of selected groups of elements. For example, the average of the atomic masses of lithium and potassium was close to the atomic mass of sodium. A similar pattern was found with calcium, strontium, and barium; with sulfur, selenium, tellurium; and with chlorine, bromine, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Nicolas Vauquelin
Louis Nicolas Vauquelin FRS(For) HFRSE (; 16 May 1763 – 14 November 1829) was a French pharmacist and chemist. He was the discoverer of chromium and beryllium. Early life Vauquelin was born at Saint-André-d'Hébertot in Normandy, France, the son of Nicolas Vauquelin, an estate manager, and his wife, Catherine Le Charterier. His first acquaintance with chemistry was gained as laboratory assistant to an apothecary in Rouen (1777–1779), and after various vicissitudes he obtained an introduction to A. F. Fourcroy, in whose laboratory he was an assistant from 1783 to 1791. Moving to Paris, he became a laboratory assistant at the Jardin du Roi and was befriended by a professor of chemistry. In 1791 he was made a member of the Academy of Sciences and from that time he helped to edit the journal '' Annales de Chimie'' ''(Chemical annals)'', although he left the country for a while during the height of the French Revolution. In 1798 Vauquelin discovered beryllium oxide by extrac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antoine François, Comte De Fourcroy
Antoine is a French given name (from the Latin ''Antonius'' meaning 'highly praise-worthy') that is a variant of Danton, Titouan, D'Anton and Antonin. The name is most common in France, Switzerland, Belgium, Canada, West Greenland, Haiti, French Guiana, Madagascar, Benin, Niger, Burkina Faso, Ivory Coast, Guinea, Senegal, Mauritania, Western Sahara, Morocco, Algeria, Tunisia, Chad, Central African Republic, Cameroon, Equatorial Guinea, Gabon, Republic of the Congo, Democratic Republic of the Congo, Burundi, and Rwanda. It is a cognate of the masculine given name Anthony. Similar names include Antaine, Anthoine, Antoan, Antoin, Antton, Antuan, Antwain, Antwan, Antwaun, Antwoine, Antwone, Antwon and Antwuan. Feminine forms include Antonia, Antoinette, and (more rarely) Antionette. As a first name *Antoine Alexandre Barbier (1765–1825), a French librarian and bibliographer *Antoine Arbogast (1759–1803), a French mathematician *Antoine Arnauld (1612–1694), a Fre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carl Wilhelm Scheele
Carl Wilhelm Scheele (, ; 9 December 1742 – 21 May 1786) was a Swedish Pomerania, German-Swedish pharmaceutical chemist. Scheele discovered oxygen (although Joseph Priestley published his findings first), and identified the elements molybdenum, tungsten, barium, nitrogen, and chlorine, among others. Scheele discovered organic acids Tartaric acid, tartaric, Oxalic acid, oxalic, Uric acid, uric, Lactic acid, lactic, and Citric acid, citric, as well as Hydrofluoric acid, hydrofluoric, Hydrocyanic acid, hydrocyanic, and Arsenic acid, arsenic acids. He preferred speaking German to Swedish his whole life, as German was commonly spoken among Swedish pharmacists.Fors, Hjalmar 2008. "Stepping through Science’s Door: C. W. Scheele, from Pharmacist's Apprentice to Man of Science". Ambix 55: 29–49 Biography Scheele was born in Stralsund, in western Pomerania, which at the time was a Dominions of Sweden, Swedish Dominion inside the Holy Roman Empire. Scheele's father, Joachim (or Jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of IARC Group 1 Carcinogens
IARC group 1 Carcinogens are substances, chemical mixtures, and exposure circumstances which have been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent ( chemical mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient, but when there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. This list focuses on the hazard linked to the agents. This means that while carcinogens are capable of causing cancer, it does not take their risk into account, which is the probability of causing a cancer, given the level of exposure to this carcinogen. The list is up to date as of January 2024. Agents Infectious conditions Viruses *Human immunodeficiency viru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogen
A carcinogen () is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruses and bacteria. Most carcinogens act by creating mutations in DNA that disrupt a cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells. The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division. The specific mechanisms for carcinogenic activity is unique to each agent and cell type. Carcinogens can be broadly categorized, however, as activation-dependent and activation-independent which relate to the agent's ability to engage dir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Agency For Research On Cancer
The International Agency for Research on Cancer (IARC; ) is an intergovernmental agency forming part of the World Health Organization of the United Nations. Its role is to conduct and coordinate research into the causes of cancer. It also cancer registry, collects and publishes disease surveillance, surveillance data regarding the occurrence of cancer worldwide. Its IARC monographs programme identifies carcinogenic hazards and evaluates environmental carcinogen, causes of cancer in humans. IARC has its own governing council, and in 1965 the first members were West Germany, France, Italy, the United Kingdom, and the United States of America. Today, IARC's membership has grown to 29 countries. History In late February 1963, after he experienced his spouse suffering and dying of cancer, journalist and Mouvement de la Paix, peace activist Yves Poggioli sent a letter to Emmanuel d'Astier de La Vigerie, Emmanuel d'Astier de la Vignerie relating his story, and urging support for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetaldehyde Dehydrogenase
Acetaldehyde dehydrogenases () are dehydrogenase enzymes which catalyze the conversion of acetaldehyde into acetyl-CoA. This can be summarized as follows: Acetaldehyde + NAD+ + Coenzyme A ↔ Acetyl-CoA + NADH + H+ In humans, there are three known genes which encode this enzymatic activity, ''ALDH1A1'', ''ALDH2'', and the more recently discovered '' ALDH1B1'' (also known as '' ALDH5''). These enzymes are members of the larger class of aldehyde dehydrogenases. The CAS number for this type of the enzyme is 028-91-5 Structure Cysteine-302 is one of three consecutive Cys residues and is crucial to the enzyme's catalytic function. The residue is alkylated by iodoacetamide in both the cytosolic and mitochondrial isozymes, with modifications to Cys-302 indicative of catalytic activity with other residues. Furthermore, the preceding sequence Gln-Gly-Gln-Cys is conserved in both isozymes for both human and horse, which is consistent with Cys-302 being crucial to catalytic function. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disulfiram
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by Enzyme inhibition, inhibiting the enzyme aldehyde dehydrogenase (specifically ALDH2), causing many of the effects of a hangover to be felt immediately following alcohol (drug), alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, shortness of breath, hyperventilation, tachycardia, fast heart rate, hypotension, low blood pressure, Syncope (medicine), fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmia, abnormal heart rhythms, myocardial infarction, heart attack, acute congestive heart failure, unconsciousness, convulsi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
