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Abelardo Aguilar
Abelardo Aguilar (November 3, 1917 – September 22, 1993) was a Filipino doctor from Iloilo, Philippines who worked as a medical representative for Eli Lilly and Company. Discovery of erythromycin In 1949, Aguilar was testing soil samples from his backyard and had discovered a method to formulate erythromycin. Saccharopolyspora erythraea, a strain of bacteria was isolated and lead to his discovery and to the development of Erythromycin, an antibiotic used today. Aguilar discovered a method to formulate Erythromycin while testing soil samples from his backyard Dr. Abelardo Aguilar isolated a strain of bacteria which lead to the development of erythromycin, a broad-spectrum antibiotic used to treat and prevent a wide range of infections. Eli Lilly and Company Eli Lilly and Company, Trade name, doing business as Lilly, is an American multinational Medication, pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manila
Manila, officially the City of Manila, is the Capital of the Philippines, capital and second-most populous city of the Philippines after Quezon City, with a population of 1,846,513 people in 2020. Located on the eastern shore of Manila Bay on the island of Luzon, it is classified as a Cities of the Philippines#Independent cities, highly urbanized city. With , Manila is one of the world's List of cities proper by population density, most densely populated cities proper. Manila was the first chartered city in the country, designated bPhilippine Commission Act No. 183on July 31, 1901. It became autonomous with the passage of Republic Act No. 409, "The Revised Charter of the City of Manila", on June 18, 1949. Manila is considered to be part of the world's original set of global cities because its commercial networks were the first to extend across the Pacific Ocean and connect Asia with the Hispanic America, Spanish Americas through the Manila galleon, galleon trade. This marked t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insular Government Of The Philippine Islands
The Philippine Insular GovernmentThis form of the name appeared in the titles of US Supreme Court cases, but was otherwise rarely used. See s:Costas v. Government of the Philippine Islands/Opinion of the Court, Costas v. Government of the Philippine Islands, 221 U.S. 623, 1911. The Administrative Code of the Philippine Islands of 1917' gives the formal name of the state as either "Insular Government" or "Government of the Philippine Islands" (p. 5). () was an unincorporated Territories of the United States, territory of the United States that was established on April 11, 1899 upon ratification of the Treaty of Paris (1898), 1898 Treaty of Paris. It was Tydings–McDuffie Act, reorganized in 1935 in preparation for later independence. The Insular Government was preceded by the Military Government of the Philippine Islands and was followed by the Commonwealth of the Philippines. The Philippines were acquired from Spain by the United States in 1898 following the Spanish–American ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythromycin
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It may also be used during pregnancy to prevent Group B streptococcal infection in the newborn, and to improve delayed stomach emptying. It can be given intravenously and by mouth. An eye ointment is routinely recommended after delivery to prevent eye infections in the newborn. Common side effects include abdominal cramps, vomiting, and diarrhea. More serious side effects may include ''Clostridioides difficile'' colitis, liver problems, prolonged QT, and allergic reactions. It is generally safe in those who are allergic to penicillin. Erythromycin also appears to be safe to use during pregnancy. While generally regarded as safe during breastfeeding, its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filipinos
Filipinos () are citizens or people identified with the country of the Philippines. Filipinos come from various Austronesian peoples, all typically speaking Filipino language, Filipino, Philippine English, English, or other Philippine languages. Despite formerly being subject to Spanish Philippines, Spanish administration, less than 1% of Filipinos are fluent in Spanish language, Spanish. Currently, there are more than 185 Ethnic groups in the Philippines, ethnolinguistic groups in the Philippines each with its own Languages of the Philippines, language, identity, culture, tradition, and history. Names The name ''Filipino'', as a demonym, was derived from the term , the name given to the archipelago in 1543 by the Spaniards, Spanish explorer and Order of Preachers, Dominican priest Ruy López de Villalobos, in honor of Philip II of Spain. During the History of the Philippines (1521–1898), Spanish period, natives of the Philippine islands were usually known in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iloilo
Iloilo ( ; ), officially the Province of Iloilo (; ; ; ), is a province in the Philippines located in the Western Visayas region. Its capital and largest city is Iloilo City, the regional center of Western Visayas and politically independent from the province. Iloilo occupies the southeast portion of the Visayan island of Panay and is bordered by the province of Antique to the west, Capiz to the north, the Jintotolo Channel to the northeast, the Guimaras Strait to the east, and the Iloilo Strait and Panay Gulf to the southwest. Iloilo City, its capital, is the center of the Iloilo–Guimaras metropolitan area or Metro Iloilo–Guimaras, and is geographically located in the province and grouped under it by the Philippine Statistics Authority, but remains politically independent from the provincial government. According to the 2020 census, the population of the province (excluding Iloilo City) is 2,051,899. If Iloilo City is included, the population is 2,509,525 in to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippines
The Philippines, officially the Republic of the Philippines, is an Archipelagic state, archipelagic country in Southeast Asia. Located in the western Pacific Ocean, it consists of List of islands of the Philippines, 7,641 islands, with a total area of roughly 300,000 square kilometers, which are broadly categorized in Island groups of the Philippines, three main geographical divisions from north to south: Luzon, Visayas, and Mindanao. With a population of over 110 million, it is the world's List of countries and dependencies by population, twelfth-most-populous country. The Philippines is bounded by the South China Sea to the west, the Philippine Sea to the east, and the Celebes Sea to the south. It shares maritime borders with Taiwan to the north, Japan to the northeast, Palau to the east and southeast, Indonesia to the south, Malaysia to the southwest, Vietnam to the west, and China to the northwest. It has Ethnic groups in the Philippines, diverse ethnicities and Culture o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company
Eli Lilly and Company, Trade name, doing business as Lilly, is an American multinational Medication, pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by Eli Lilly, a pharmaceutical chemist and Union army veteran during the American Civil War for whom the company was later named. As of October 2024, Lilly is the most valuable drug company in the world with a $842 billion market capitalization, the highest valuation ever achieved to date by a drug company. The company is ranked 127th on the Fortune 500, ''Fortune'' 500 with revenue of $34.12 billion. It is ranked 221st on the Forbes Global 2000, ''Forbes'' Global 2000 list of the world's largest publicly traded companies and 252nd on ''Forbes'' list of "America's Best Employers". Lilly is known for its Major depressive disorder, clinical depression drugs Prozac (fluoxetine) (1986), Cymbalta (duloxet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saccharopolyspora Erythraea
''Saccharopolyspora erythraea'' is a species of actinomycete bacteria within the genus '' Saccharopolyspora''. ''Saccharopolyspora erythraea'' produces the macrolide antibiotic erythromycin. Cytochrome P450 Cytochromes P450 (P450s or CYPs) are a Protein superfamily, superfamily of enzymes containing heme as a cofactor (biochemistry), cofactor that mostly, but not exclusively, function as monooxygenases. However, they are not omnipresent; for examp ... eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B. Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis. References External linksType strain of ''Saccharopolyspora erythraea'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Pseudonocardineae {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, Hot spring, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the nitrogen fixation, fixation of nitrogen from the Earth's atmosphere, atmosphere. The nutrient cycle includes the decomposition of cadaver, dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythromycin
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It may also be used during pregnancy to prevent Group B streptococcal infection in the newborn, and to improve delayed stomach emptying. It can be given intravenously and by mouth. An eye ointment is routinely recommended after delivery to prevent eye infections in the newborn. Common side effects include abdominal cramps, vomiting, and diarrhea. More serious side effects may include ''Clostridioides difficile'' colitis, liver problems, prolonged QT, and allergic reactions. It is generally safe in those who are allergic to penicillin. Erythromycin also appears to be safe to use during pregnancy. While generally regarded as safe during breastfeeding, its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1917 Births
Events Below, the events of World War I have the "WWI" prefix. January * January 9 – WWI – Battle of Rafa: The last substantial Ottoman Army garrison on the Sinai Peninsula is captured by the Egyptian Expeditionary Force's Desert Column. * January 10 – Imperial Trans-Antarctic Expedition: Seven survivors of the Ross Sea party are rescued after being stranded for several months. * January 11 – Unknown saboteurs set off the Kingsland Explosion at Kingsland (modern-day Lyndhurst, New Jersey), one of the events leading to United States involvement in WWI. * January 16 – The Danish West Indies is sold to the United States for $25 million (equivalent to $ million in ). * January 22 – WWI: United States President Woodrow Wilson calls for "peace without victory" in Germany. * January 25 – WWI: British armed merchantman is sunk by mines off Lough Swilly (Ireland), with the loss of 354 of the 475 aboard. * January 26 – The se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1993 Deaths
This is a list of lists of deaths of notable people, organized by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked below. 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Earlier years ''Deaths in years earlier than this can usually be found in the main articles of the years.'' See also * Lists of deaths by day * Deaths by year (category) {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
