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ASF1B
Histone chaperone ASF1B is a protein that in humans is encoded by the ''ASF1B'' gene. Function This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. Interactions ASF1B has been shown to interact with TLK2, CHAF1B, TLK1 and CHAF1A Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the ''CHAF1A'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides .... References Further reading * * * * * * * * * External links * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLK2
Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the ''TLK2'' gene. Function The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "tousled" varieties, such as flock-of-seagulls, post-coitus, or the-Sean-Bean. upplied by OMIMref name="entrez" /> Interactions TLK2 has been shown to interact with TLK1, ASF1B and ASF1A. Clinical significance Mutations in this gene have been linked to a specific form of autism spectrum disorder Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing di ... with unique facial features. Amplifications of the nuclear localization sequence-encoding part of this gene have been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CHAF1B
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the ''CHAF1B'' gene. Function Chromatin assembly factor I ( CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. Interactions CHAF1B has been shown to interact with: * ASF1A, * ASF1B, and * BAZ1B Tyrosine-protein kinase, or Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by the ''BAZ1B'' gene. Function This gene encodes a member of the bromod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLK1
Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the ''TLK1'' gene. Function The Tousled-like kinases, first described in Arabidopsis ''Arabidopsis'' (rockcress) is a genus in the family Brassicaceae. They are small flowering plants related to cabbage and mustard. This genus is of great interest since it contains thale cress (''Arabidopsis thaliana''), one of the model organ ..., are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. upplied by OMIMref name="entrez" /> Interactions TLK1 has been shown to interact with ASF1B, ASF1A and TLK2. References Further reading * * * * * * * * * * * * * * {{Gene-2-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
