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AION Labs
AION Labs is an Israeli venture studio focused on the adoption of artificial intelligence (AI) and machine learning (ML) in pharmaceutical discovery and development processes. It is backed by eight major companies in the pharmaceutical, technology, and investing sectors. This partnership includes pharmaceutical companies AstraZeneca, Merck KGaA, Pfizer, and Teva Pharmaceuticals; venture capital firms Israel Biotech Fund and Amiti Ventures; strategic partner Amazon Web Services; and independent research institute BioMed X, with support from the Israel Innovation Authority. History AION Labs was formed after winning a government tender in 2020, bringing together AstraZeneca, Merck KGaA, Pfizer, and Teva—from the pharmaceutical sector—with Amazon Web Services (AWS), a technology and cloud computing provider, and biotech and deeptech VC firms Israel Biotech Fund and Amiti Ventures. The Management team of the company includes CEO Mati Gill, CTO Yair Benita, Dr. Sharon Kredo-Rus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Israel
Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Israeli-occupied territories, It occupies the Occupied Palestinian territories, Palestinian territories of the West Bank in the east and the Gaza Strip in the south-west. Israel also has a small coastline on the Red Sea at its southernmost point, and part of the Dead Sea lies along its eastern border. Status of Jerusalem, Its proclaimed capital is Jerusalem, while Tel Aviv is the country's Gush Dan, largest urban area and Economy of Israel, economic center. Israel is located in a region known as the Land of Israel, synonymous with the Palestine (region), Palestine region, the Holy Land, and Canaan. In antiquity, it was home to the Canaanite civilisation followed by the History of ancient Israel and Judah, kingdoms of Israel and Judah. Situate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deep Tech
Deep technology (deep tech) is a classification of organization, or more typically startup company, with the expressed objective of providing technology solutions based on substantial scientific or engineering challenges. They present challenges requiring lengthy research and development, and large capital investment before successful commercialization. Their primary risk is technical risk, while market risk is often significantly lower due to the clear potential value of the solution to society. The underlying scientific or engineering problems being solved by deep tech (and hard tech companies) generate valuable intellectual property and are hard to reproduce. Definition The term "deep tech" has been present for decades, representing R&D divisions at major defense and telecommunications corporations such as Raytheon Technologies, Lockheed Martin's Skunk Works, and Bell Labs, to the more modern definition which increasingly includes companies found in the venture capital eco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Financial Services Companies Established In 2020
Finance refers to monetary resources and to the study and discipline of money, currency, assets and liabilities. As a subject of study, is a field of Business Administration wich study the planning, organizing, leading, and controlling of an organization's resources to achieve its goals. Based on the scope of financial activities in financial systems, the discipline can be divided into personal, corporate, and public finance. In these financial systems, assets are bought, sold, or traded as financial instruments, such as currencies, loans, bonds, shares, stocks, options, futures, etc. Assets can also be banked, Investment, invested, and Insurance, insured to maximize value and minimize loss. In practice, Financial risk, risks are always present in any financial action and entities. Due to its wide scope, a broad range of subfields exists within finance. Asset management, Asset-, Money management, money-, Financial risk management, risk- and investment management aim to maxim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Venture Capital Firms Of Israel
Venture may refer to: Arts and entertainment Music *The Ventures, an American instrumental rock band formed in 1958 *"A Venture", 1971 song by the band Yes *''Venture'', a 2010 EP by AJR Games * ''Venture'' (video game), a 1981 arcade game *''Venture'', a strategic card game by Sid Sackson * Venture (''Overwatch''), a playable character from the video game ''Overwatch 2'' Film * SS ''Venture'', a ship in ''King Kong'' and its 2005 remake * SS ''Venture'', an InGen-owned ship featured in '' The Lost World: Jurassic Park'' Other uses * ''Venture'' (TV series), a Canadian business television show Magazines * ''Venture Science Fiction'', defunct US science fiction magazine * ''Venture'' (magazine), a management magazine Business * Business venture * Venture (department store), a defunct discount department store operating across Australia * Venture Stores, a former retail chain Transportation * Chevrolet Venture, a General Motors minivan * Yamaha Venture, Yamaha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapeutic Antibodies
Monoclonal antibodies (mAbs) have varied therapeutic uses. It is possible to create a mAb that binds specifically to almost any extracellular target, such as cell surface proteins and cytokines. They can be used to render their target ineffective (e.g. by preventing receptor binding), to induce a specific cell signal (by activating receptors), to cause the immune system to attack specific cells, or to bring a drug to a specific cell type (such as with radioimmunotherapy which delivers cytotoxic radiation). Major applications include cancer, autoimmune diseases, asthma, organ transplants, blood clot prevention, and certain infections. Antibody structure and function Immunoglobulin G ( IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of polypeptide chain, called the heavy (~50kDa) and the light chain (~25kDa). The two types of light chains are kappa (κ) and lambda (λ). By cleavage with enzyme papain, the Fab (''fragment-an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Venture Round
A venture round is a type of funding round used for venture capital financing, by which startup company, startup companies obtain investment, generally from venture capitalists and other institutional investors. The availability of venture funding is among the primary stimuli for the development of new companies and technologies. Features Parties *Founders or Project stakeholder, stakeholders. Introduce companies to investors. *A lead investor, typically the best known or most aggressive venture capital firm that is participating in the investment, or the one contributing the largest amount of cash. The lead investor typically oversees most of the negotiation, legal work, due diligence, and other formalities of the investment. It may also introduce the company to other investors, generally in an informal unpaid capacity. *Co-investors, other major investors who contribute alongside the lead investor. *Follow-on or piggyback investors. Typically angel investors, high-net worth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process—from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials—to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. These h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Discovery
In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products, or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Modern drug discovery i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Degradation
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Protein degradation is a major regulatory mechanism of gene expression and contributes substantially to shaping mammalian proteomes. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing the accumulation of unwanted or misfolded proteins in cells. Consequently, abnormality in the regulation of proteolysis can cause diseases. Proteolysis can also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Glue
A molecular glue is a type of small molecule that modulates protein–protein interactions in cells by enhancing the affinity between proteins. These compounds can induce novel interactions between proteins (type I) or stabilize pre-existing ones (type II), offering an alternative strategy to traditional drug discovery. Molecular glues have shown promise in targeting proteins previously considered "undruggable" by conventional methods. They work through various mechanisms, such as promoting protein degradation or inhibiting protein function, and are being studied for potential use in treating cancer, neurodegenerative disorders, and other diseases. Unlike PROTACs, which are rationally designed heterobifunctional molecules that contain two covalently linked ligands that bind respectively to a target protein and an E3 ligase, molecular glues are small, monofunctional compounds typically discovered serendipitously through screening or chance observations. Mechanism of action ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chief Executive Officer
A chief executive officer (CEO), also known as a chief executive or managing director, is the top-ranking corporate officer charged with the management of an organization, usually a company or a nonprofit organization. CEOs find roles in various organizations, including public and private corporations, Nonprofit organization, nonprofit organizations, and even some government organizations (notably state-owned enterprises). The governor and CEO of a corporation or company typically reports to the board of directors and is charged with maximizing the value of the business, which may include maximizing the profitability, market share, revenue, or another financial metric. In the nonprofit and government sector, CEOs typically aim at achieving outcomes related to the organization's mission, usually provided by legislation. CEOs are also frequently assigned the role of the main manager of the organization and the highest-ranking officer in the C-suite. Origins The term "chief executi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
