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AF4 (protein)
AF4 may refer to: * AF4/FMR2 family member 1, a human protein * Asymmetric flow field flow fractionation Asymmetrical flow field-flow fractionation (AF4) is most versatile and most widely used sub-technique within the family of field flow fractionation (FFF) methods. AF4 can be used in aqueous and organic solvents and is able to characterize nanoparti ..., a method for polymer characterization * AF4: an EEG electrode site according to the 10-20 system {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AF4/FMR2 Family Member 1
AF4/FMR2 family member 1 is a protein that in humans is encoded by the ''AFF1'' gene. At its same location was a record for a separate PBM1 gene, which has since been withdrawn and considered an alias. It was previously known as AF4 (ALL1-fused gene from chromosome 4). The gene is a member of the AF4/FMR2 (AFF) family, a group of nuclear transcriptional activators which encourage RNA elongation. It is a component of the super elongation complex. It is recognized as a proto-oncogene: chromosomal translocations associated with leukemia can fuse this gene with others like KMT2A Histone-lysine ''N''-methyltransferase 2A also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX) is an enzyme that in humans is encoded by the ''KMT2A'' gene. ML ..., producing an uncontrolled activator protein. References External links * Further reading * * * * * * * * * * * * * * * * {{ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asymmetric Flow Field Flow Fractionation
Asymmetrical flow field-flow fractionation (AF4) is most versatile and most widely used sub-technique within the family of field flow fractionation (FFF) methods. AF4 can be used in aqueous and organic solvents and is able to characterize nanoparticles, polymers and proteins. The theory for AF4 was conceived in 1986 and was established in 1987 and first published by Wahlund and Giddings. AF4 is distinct from symmetrical Flow FFF because it contains only one permeable wall so the cross-flow is caused only by the carrier liquid. The cross-flow is induced by the carrier liquid constantly exiting by way of the semi-permeable wall on the bottom of the channel. Applications and detection methods Asymmetrical flow field flow fractionation (AF4) is nowadays a common and state-of-the art method for fractionation and separation of macromolecules and particles in a suspension. AF4 is an alternative to HPLC and SEC in cases where column chromatography is not suitable for the analyte. HPLC or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
