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6-MBPB
6-MBPB, also known as 6-(2-methylaminobutyl)benzofuran (6-MABB), is a monoamine releasing agent (MRA) and entactogen-like drug of the substituted amphetamine, amphetamine, phenylisobutylamine, and substituted benzofuran, benzofuran families. It is a positional isomer of 5-MBPB (5-MABB). The drug appears to act as a serotonin–norepinephrine–dopamine releasing agent (SNDRA). The values for induction of monoamine release in rat brain synaptosomes have been reported for the individual enantiomers of 6-MBPB. In the case of (''S'')-6-MBPB, they were 54nM for serotonin, 77nM for norepinephrine, and 41nM for dopamine, whereas for (''R'')-6-MBPB, they were 172nM for serotonin, 227nM for norepinephrine, and inactive for dopamine. Hence, (''S'')-6-MBPB is an SNDRA, whereas (''R'')-MBPB is a serotonin–norepinephrine releasing agent (SNRA). The enantiomers showed a mixed profile of acting as full versus partial monoamine releaser, partial releasers. 6-MBPB partially substituted for MDMA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Monoamine Releaser
A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the synapse, release of one or more monoamine neurotransmitters from the synapse, presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitters and hence enhanced cell signaling, signaling by those neurotransmitters. The monoamine neurotransmitters include serotonin, norepinephrine, and dopamine; MRAs can induce the release of one or more of these neurotransmitters. MRAs work by reversing the direction of the monoamine transporters (MATs), including the serotonin transporter (SERT), norepinephrine transporter (NET), and/or dopamine transporter (DAT), causing them to promote efflux (microbiology), efflux of synaptic vesicle, non-vesicular cytoplasmic monoamine neurotransmitter rather than reuptake of synapse, synaptic monoamine neurotransmitter. Many, but not all MRAs, also reverse the direction of the vesicular monoamine transporter 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
