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6-Hydroxyflavone
6-Hydroxyflavone is a flavone, a type of chemical compound. It is one of the noncompetitive inhibitors of cytochrome P450 2C9. It is reported in ''Crocus'' and leaves of '' Barleria prionitis'' Linn. (a common Acanthaceae from India). 6-Hydroxyflavone shows anxiolytic activity in a mouse model. Compared to the full agonist diazepam Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is used to treat a range of conditions, including anxiety disorder, anxiety, seizures, alcohol withdrawal syndr ..., 6-hydroxyflavone was approximately 200 times less potent. References Flavones Steroid sulfotransferase inhibitors {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crocus
''Crocus'' (; plural: crocuses or croci) is a genus of seasonal flowering plants in the family Iridaceae (iris family) comprising about 100 species of perennial plant, perennials growing from corms. They are low growing plants, whose flower stems remain underground, that bear relatively large white, yellow, orange or purple flowers and then become dormant after flowering. Many are cultivated for their flowers, appearing in autumn, winter, or spring. The flowers close at night and in overcast weather conditions. The crocus has been known throughout recorded history, mainly as the source of saffron. Saffron is obtained from the dried Stigma (botany), stigma of ''Crocus sativus'', an autumn-blooming species. It is valued as a spice and dyestuff, and is one of the most expensive spices in the world. Iran is the center of saffron production. Crocuses are native plant, native to woodland, scrub, and meadows from sea level to alpine tundra from the Mediterranean Sea, Mediterranean, throu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barleria Prionitis
''Barleria prionitis'' is a shrub in the family Acanthaceae, native to Island and Mainland Southeast Asia, China, the Indian Subcontinent, the Arabian Peninsula and northeastern Africa. It is widely spread as an ornamental and weed, occurring in naturalised populations around the world. It used not only as an ornamental but also as a hedge and extensively as a component of folk medicines. As a weed it is regarded as problematic in many areas. Description A much-branched shrub up to 1.8m tall, the lower leaf axils have spines 1–2 cm in length, one of the specific features of this ''Barleria''. The stem and branches are terete, smooth, lenticellate and glabrous. The leaves are elliptic to ovate (4-10.5 × 1.8-5.5 cm) with both surfaces pubescent when young but becoming glabrescent soon. The large golden-yellow flowers are clustered in the axils of the upper leaves and/or on bracts. Apically spinose calyx lobes and a yellowish to orange corolla are used to distinguish thi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flavone
Flavone is an organic compound with the formula . A white solid, flavone is a derivative of chromone with a phenyl (Ph) substituent adjacent to the ether group. The compound is of little direct practical importance, but substituted derivatives, the flavones and flavonoids are a large class of nutritionally important natural products. Flavone can be prepared in the laboratory by cyclization of 2-hydrox acetophenone. Isomeric with flavone is isoflavone, where the phenyl group is adjacent to the ketone In organic chemistry, a ketone is an organic compound with the structure , where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group (a carbon-oxygen double bond C=O). The simplest ketone is acetone ( .... References {{Flavones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome P450 2C9
Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the protein is encoded by the ''CYP2C9'' gene. The gene is highly polymorphic, which affects the efficiency of the metabolism by the enzyme. Function CYP2C9 is a crucial cytochrome P450 enzyme, which plays a significant role in the metabolism, by oxidation, of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes. The protein is mainly expressed in the liver, duodenum, and small intestine. About 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin, and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acanthaceae
Acanthaceae () is a Family (biology), family (the acanthus family) of dicotyledonous flowering plants containing almost 250 genera and about 2500 species. Most are Tropics, tropical Herbaceous plant, herbs, shrubs, or twining vines; some are epiphytes. Only a few species are distributed in temperate regions. The four main centres of distribution are Indonesia and Malaysia, Africa, Brazil, and Central America. Representatives of the family can be found in nearly every Habitat (ecology), habitat, including dense or open forests, scrublands, wet fields and valleys, sea coast and marine areas, swamps, and mangrove forests. Description Plants in this family have simple, opposite, decussated leaf, leaves with entire (or sometimes toothed, lobed, or spiny) margins, and without stipules. The leaves may contain cystoliths, calcium carbonate concretions, seen as streaks on the surface. The flowers are perfect, Floral symmetry, zygomorphic to nearly Floral symmetry, actinomorphic, and arran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anxiolytic
An anxiolytic (; also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiety disorders and their related psychological and physical symptoms. Nature of anxiety Anxiety is a naturally-occurring emotion and response. When anxiety levels exceed the tolerability of a person, anxiety disorders may occur. People with anxiety disorders can exhibit fear responses, such as defensive behaviors, high levels of alertness, and negative emotions. Those with anxiety disorders may have concurrent psychological disorders, such as depression. Anxiety disorders are classified using six possible clinical assessments: Different types of anxiety disorders will share some general symptoms while having their own distinctive symptoms. This explains why people with different types of anxiety disorders will respond differently to diffe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mouse Model
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Research using animal models has been central to most of the achievements of modern medicine. It has contributed most of the basic knowledge in fields such as human physiology and biochemistry, and has played significant roles in fields such as neuroscience and infectious disease. The results have included the near- eradication of polio and the development of organ transplantation, and have benefited both humans and animals. From 1910 to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is used to treat a range of conditions, including anxiety disorder, anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. It may also be used to cause amnesia, memory loss during certain medical procedures. It can be taken Oral administration, orally (by mouth), as a suppository inserted into the rectum, Intramuscular injection, intramuscularly (injected into muscle), Intravenous therapy, intravenously (injection into a vein) or used as a nasal spray. When injected intravenously, effects begin in one to five minutes and last up to an hour. When taken by mouth, effects begin after 15 to 60 minutes. Common side effects include sleepiness and trouble with coordination. Serious side effects are rare. They include increased risk of suicide, decreased breathing, and a paradoxical increased risk of seizures ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flavones
Flavones (from Latin ''flavus'' "yellow") are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) (as shown in the first image of this article). Flavones are common in foods, mainly from spices, and some yellow or orange fruits and vegetables. Common flavones include apigenin (4',5,7-trihydroxyflavone), luteolin (3',4',5,7-tetrahydroxyflavone), tangeritin (4',5,6,7,8-pentamethoxyflavone), chrysin (5,7-dihydroxyflavone), and 6-hydroxyflavone. Intake and elimination The estimated daily intake of flavones is about 2 mg per day. Following ingestion and metabolism, flavones, other polyphenols, and their metabolites are absorbed poorly in body organs and are rapidly excreted in the urine, indicating mechanisms influencing their presumed absence of metabolic roles in the body. Drug interactions Flavones have effects on CYP (P450) activity, which are enzymes that metabolize most drugs in the body. Biosynthesis The biosynthesis of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
