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5-HO-DET
5-HO-DET, or 5-hydroxy-DET, also known as 5-hydroxy-''N'',''N''-diethyltryptamine, is a serotonin receptor modulator of the tryptamine and 5-hydroxytryptamine families related to the psychedelic drug bufotenin (5-HO-DMT). It is the derivative of bufotenin in which the ''N'',''N''-dimethyl groups have been replaced with ''N'',''N''-diethyl groups. The drug is also the ''N'',''N''-diethyl derivative of serotonin (5-hydroxytryptamine) and the 5- hydroxy derivative of diethyltryptamine (DET). It shows relatively low potency in terms of psychedelic-like behavioral effects in the conditioned avoidance response test in rodents. It has been suggested that this might be due to 5-HO-DET having poor lipophilicity and blood–brain barrier permeability analogously to bufotenin. However, 5-HO-DET has significantly greater lipophilicity than bufotenin owing to its ethyl instead of methyl groups (predicted log P = 1.9 and 1.2, respectively). 5-HO-DET has been assessed and found to show high aff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Tryptamine
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-MeO-DET
5-MeO-DET, also known as 5-methoxy-''N'',''N''-diethyltryptamine is a psychedelic drug of the substituted tryptamine, tryptamine family related to 5-MeO-DMT. Use and effects Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects. Alexander Shulgin, Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions. One user referred to it as a "torture psychedelic". The prominent adverse effects of 5-MeO-DET even at low doses prevent it from being taken at fully hallucinogenic doses. Its duration of action, duration is said to be 3 to 4hours. Interactions Pharmacology 5-MeO-DET inhibits Serotonin reuptake inhibitor, serotonin reuptake with an IC50 value of 2.4 μM and activates 5-HT2A receptor, 5-HT2A receptors with an EC50 value of 8.11 nM. The drug fully substitutes for DOM (drug), DOM in rodent drug discrimination tests. It also substitutes for 5-MeO-DMT in rodent drug discrimination tests. Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HO-DiPT
5-HO-DiPT (5-hydroxy-''N,N''-di-''iso''-propyltryptamine) is a tryptamine derivative which acts as a serotonin receptor agonist. It is primarily known as a metabolite of the better known psychoactive drug 5-MeO-DiPT, but 5-HO-DiPT has also rarely been encountered as a designer drug in its own right. Tests ''in vitro'' show 5-HO-DiPT to have high 5-HT2A affinity and good selectivity over 5-HT1A, while being more lipophilic than the related drug bufotenine (5-HO-DMT), which produces mainly peripheral effects. See also * Substituted tryptamine * 5-HO-DPT * 5-HO-DET * α-Methylserotonin * 4-HO-DiPT 4-HO-DiPT, also known as 4-hydroxy-''N'',''N''-diisopropyltryptamine or as iprocin, is a synthetic compound, synthetic psychedelic drug of the substituted tryptamine, tryptamine family. It is a higher homologous series, homologue of psilocin and ... * 4-HO-DSBT * 5-AcO-DMT References N,N-Dialkyltryptamines Diisopropylamino compounds 5-Hydroxytryptamines {{psycho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HO-DPT
5-HO-DPT, also known as 5-hydroxy-''N'',''N''-dipropyltryptamine, as well as ''N'',''N''-dipropylserotonin (DiPS or NDPS), is a serotonin receptor modulator of the tryptamine and 5-hydroxytryptamine families. It is the ''N'',''N''-dipropyl derivative of serotonin (5-hydroxytryptamine; 5-HT). Pharmacology The drug shows affinity for the serotonin 5-HT1A receptor (Ki = 7.1nM), the serotonin 5-HT1B receptor (Ki = 4,300nM), and the serotonin 5-HT2 receptor (Ki = 1.0–450nM). 5-HO-DPT was not tested itself, but its ''O''-methyl ether 5-MeO-DPT fully substituted for the psychedelic drug DOM in rodent drug discrimination tests and partially substituted for 8-OH-DPAT in these tests followed by behavioral disruption at higher doses. 5-Hydroxytryptamines like bufotenin (5-HO-DMT) are known to be hydrophilic and peripherally selective, in turn resulting in difficulty crossing the blood–brain barrier and exerting central effects, but 5-HO-DPT is notable in having much greater lip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diethyltryptamine
DET, also known under its chemical name ''N'',''N''-diethyltryptamine and as T-9, is a psychedelic drug closely related to DMT and 4-HO-DET. DET, alongside DMT, was placed into the UN Schedule 1 list of illegal drugs in the 1970s, and is uncommon now. Use DET is active at an oral dose of around 50 to 100mg and the effects last for about 2 to 4hours. Interactions Pharmacology Pharmacodynamics The mechanism of action of DET is thought to be serotonin receptor agonism, much like other classic psychedelics. It is a serotonin 5-HT2A receptor agonist. The drug produces the head-twitch response in rodents, a behavioral proxy of psychedelic-like effects. Pharmacokinetics Unlike DMT, DET is orally active as it is not subject to extensive metabolism by monoamine oxidase A. This may be due to the increased steric bulk of the N-ethyl substituents relative to the respective methyl groups of DMT. This is also true for many other tryptamines with larger nitrogen substituents. Ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin Receptor Modulator
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin (i.e., 5-hydroxytryptamine, hence "5-HT") receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. Serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation. They are the target of a variety of pharmaceutical and recreational drugs, includin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Affinity (pharmacology)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from Latin ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. The binding typically results in a change of conformational isomerism (conformation) of the target protein. In DNA-ligand binding studies, the ligand can be a small molecule, ion, or protein which binds to the DNA double helix. The relationship between ligand and binding partner is a function of charge, hydrophobicity, and molecular structure. Binding occurs by intermolecular forces, such as ionic bonds, hydrogen bonds and Van der Waals forces. The association or docking is actually reversible through dissociation. Measurably irreversible covalent bonding between a ligand and target molecule is atypical in biological systems. In contrast to the definition o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-Methylserotonin
''N''-Methylserotonin, also known as norbufotenin or as 5-hydroxy-''N''-methyltryptamine (5-HO-NMT, is a tryptamine alkaloid. Chemically, it is a derivative of serotonin in which a methyl group resides at its alkyl amine. It is also called ''N''ω-methylserotonin (''N''ω-methyl-5-hydroxytryptamine) to distinguish it from tryptamine-derived compounds in which a methyl group is bonded to the nitrogen atom of the indole group. ''N''-Methylserotonin is found in plants, animals, and fungi. These include the plants, ''Actaea racemosa'' (black cohosh) and ''Zanthoxylum piperitum'', the Green and Golden Bell Frog, '' Litoria aurea'', and ''Amanita'' mushrooms. Pharmacology The compound binds to several serotonin receptors, including the 5-HT7 and 5-HT1A receptors, with high affinity ( IC50 ≤ 2 nM) and selectivity, and displays agonist activity. It also shows lower affinity for other serotonin receptors. Besides its direct interaction with the serotonin receptors, ''N''-methylsero ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
