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2F-MAR
2'-Fluoro-4-methylaminorex (2F-MAR, 2'-F-4-MAR) is a recreational designer drug from the substituted aminorex family, with stimulant effects, first reported in 2018. See also * 2C-B-aminorex * 4,4'-DMAR * 4'-Fluoro-4-methylaminorex * 4-Methylaminorex * 4C-MAR * MDMAR * 2-Fluoroamphetamine * 2-Fluoromethamphetamine 2-Fluoromethamphetamine (2-FMA) is a stimulant drug of the amphetamine family which has been used as a designer drug. 2-FMA is commonly compared to lisdexamfetamine (Vyvanse), and dextroamphetamine due to its efficacy as a study or productivit ... References Aminorexes Designer drugs 2-Fluorophenyl compounds {{pharm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Aminorex Analogues
This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after it was discovered that extended use produced pulmonary hypertension, often followed by heart failure, which resulted in a number of deaths. A designer drug analogue 4-methylaminorex appeared on the illicit market in the late 1980s but did not attract significant popularity due to its steep dose-response curve and tendency to produce seizures. Pemoline, the 4-keto derivative of aminorex, had been discovered several years earlier, and derivatives of this type appeared to be effective stimulants with comparatively low toxicity. Pemoline was sold for around 25 years as a therapy for ADHD and relief of fatigue, before being withdrawn from the market in 2005 because of rare but serious cases of liver failure. More recently in around 2014 another ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4,4'-DMAR
4,4'-Dimethylaminorex (abbreviated as 4,4'-DMAR), sometimes referred to by the street name "Serotoni", is a psychostimulant and entactogen designer drug related to aminorex, 4-methylaminorex, and pemoline. It was first detected in the Netherlands in December 2012, and has been sold as a designer drug around Europe since mid-2013. 4,4'-DMAR had been linked to at least 31 deaths in Hungary, Poland, and the UK by February 2014, mostly when consumed in combination with other drugs. Nineteen deaths linked to 4,4'-DMAR were reported in Northern Ireland in the same time period. Pharmacology Pharmacodynamics 4,4'-DMAR is a monoamine releasing agent (MRA) and acts specifically as a highly potent and well-balanced serotonin-norepinephrine-dopamine releasing agent (SNDRA), with EC50 values for serotonin, norepinephrine, and dopamine release of 18.5nM, 26.9nM, and 8.6nM, respectively. It also interacts with the vesicular monoamine transporter 2 (VMAT2) with similar potency as MDMA. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4'-Fluoro-4-methylaminorex
4'-Fluoro-4-methylaminorex (4F-MAR, 4-FPO) is a recreational designer drug from the substituted aminorex family, with stimulant effects. It was first detected in Slovenia in 2018. It was made illegal in Italy in March 2020. See also * 2C-B-aminorex * 2F-MAR * 3-Fluorophenmetrazine * 4C-MAR * 4-Fluoroamphetamine * 4,4'-DMAR * Fluminorex * MDMAR * List of aminorex analogues This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after ... References Aminorexes Designer drugs 4-Fluorophenyl compounds {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4C-MAR
4'-Chloro-4-methylaminorex (4C-MAR, 4'-Cl-4-MAR) is a recreational designer drug from the List of aminorex analogues, substituted aminorex family, with stimulant effects. It has reportedly been sold since around 2021 and was first definitively identified in Austria in January 2022. See also * 2C-B-aminorex * 2F-MAR * 4B-MAR * 4,4'-DMAR * 4'-Fluoro-4-methylaminorex * 4-Methylaminorex * Clominorex * MDMAR * 4-Chloroamphetamine * 4-Chloromethcathinone References Aminorexes 4-Chlorophenyl compounds Designer drugs {{pharm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-Fluoromethamphetamine
2-Fluoromethamphetamine (2-FMA) is a stimulant drug of the amphetamine family which has been used as a designer drug. 2-FMA is commonly compared to lisdexamfetamine (Vyvanse), and dextroamphetamine due to its efficacy as a study or productivity aid. 2-FMA is purported to produce somewhat less euphoria than comparable amphetamines, likely due to its main mechanism of action consisting of norepinephrine reuptake inhibition. Chemistry 2-Fluoromethamphetamine is fluorinated analogue of methamphetamine, and is a regioisomer of 3-FMA and 4-FMA. It does not activate the serotonin receptors, including 5-HT2A, unlike most stimulant drugs of the amphetamine family. Legal status Canada As of 1996, 2-FMA is a controlled substance in Canada, due to being an analog of methamphetamine. China As of October 2015, 2-FMA is a controlled substance in China. Germany As of 13 December 2014, 2-FMA is a controlled substance in Germany. It is controlled under Anlage I BtMG (Narcotics Act, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminorexes
This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after it was discovered that extended use produced pulmonary hypertension, often followed by heart failure, which resulted in a number of deaths. A designer drug analogue 4-methylaminorex appeared on the illicit market in the late 1980s but did not attract significant popularity due to its steep dose-response curve and tendency to produce seizures. Pemoline, the 4-keto derivative of aminorex, had been discovered several years earlier, and derivatives of this type appeared to be effective stimulants with comparatively low toxicity. Pemoline was sold for around 25 years as a therapy for ADHD and relief of fatigue, before being withdrawn from the market in 2005 because of rare but serious cases of liver failure. More recently in around 2014 another ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, Mood disorder, mood, and physical activity, physical performance. Some stimulants occur naturally, while others are exclusively synthetic. Common stimulants include caffeine, nicotine, amphetamines, cocaine, methylphenidate, and modafinil. Stimulants may be subject to varying forms of regulation, or outright prohibition, depending on jurisdiction. Stimulants increase activity in the sympathetic nervous system, either directly or indirectly. Prototypical stimulants increase synaptic concentrations of neurotransmitter, excitatory neurotransmitters, particularly norepinephrine and dopamine (e.g., methylphenidate). Other stimulants work by binding to the Receptor (biochemistry), receptors of excitatory neurotransmitters (e.g., nicotine) or by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2C-B-aminorex
2C-B-aminorex (2C-B-AR) is a recreational designer drug with psychedelic effects. It is a substituted aminorex derivative which was first identified in Sweden in June 2019. Structurally, it is a hybrid of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and aminorex. See also * 2C-B * 2C-B-morpholine * 2C-B-PP * BOB (psychedelic) * 4,4'-DMAR * 4'-Fluoro-4-methylaminorex * 4B-MAR * 4C-MAR * List of aminorex analogues This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after ... References 2,5-Dimethoxyphenethylamines Aminorexes Bromoarenes Designer drugs Psychedelic phenethylamines {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Methylaminorex
4-Methylaminorex (4-MAR, 4-MAX) is a stimulant drug of the 2-amino-5-aryloxazoline group that was first synthesized in 1960 by McNeil Laboratories. It is also known by its street name "U4Euh" ("Euphoria"). It is banned in many countries as a stimulant. 4-Methylaminorex has effects comparable to methamphetamine but with a longer duration. Chemistry 4-Methylaminorex exists as four stereoisomers : (±)-''cis'' and (±)-''trans''. The (±)-''cis'' isomers are the form used recreationally. Synthesis The (±)-''cis'' isomers acemate (1:1-mixture) of the (4''R'',5''S'')-isomer and the enantiomeric (4''S'',5''R'')-isomergenerally synthesized from dl-phenylpropanolamine in one step by cyclization with cyanogen bromide (sometimes prepared ''in situ'' by reacting sodium cyanide with bromine). Alternate synthesis routes generally involve more steps, such as replacing cyanogen bromide with sodium or potassium cyanate to form an intermediate and then reacting it with concentrated hydroch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDMAR
3',4'-Methylenedioxy-4-methylaminorex (MDMAR) is a recreational designer drug from the substituted aminorex family, with monoamine-releasing effects. It is a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA). See also * 2C-B-aminorex * 4B-MAR * 4C-MAR * 4,4'-DMAR * 4'-Fluoro-4-methylaminorex * 5-MAPB * MDMA * Methylenedioxyphenmetrazine * List of aminorex analogues This is a list of aminorex analogues, also known as substituted 2-amino-5-aryloxazolines. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after ... References Aminorexes Designer drugs Methylenedioxyphenethylamines {{psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
