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25O-NBOMe
25O-NBOMe, also known as 2,4,5-TMPEA-NBOMe or as ''N''-(2-methoxybenzyl)-2,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator and putative psychedelic drug of the phenethylamine and 25-NB (NBOMe) families. It is the ''N''-(2-methoxybenzyl) derivative of 2C-O (2,4,5-trimethoxyphenethylamine). The drug is known to act as a serotonin 5-HT2A receptor partial agonist, with an of 1.02 to 7.24nM and an of 57 to 129%. It activated the serotonin 5-HT2A receptor with 191- to 309-fold higher potency than 2C-O ''in vitro''. 25O-NBOMe robustly and dose-dependently induces the head-twitch response, a behavioral proxy of psychedelic effects, in mice, with an of 0.70mg/kg. For comparison, in other studies in mice, the of 25I-NBOMe was 0.078mg/kg (9-fold lower) and of 25D-NBOMe was 0.23mg/kg (3-fold lower). 25O-NBOMe was first described in the scientific literature by 2009. See also * 25-NB * 25H-NBOMe 25H-NBOMe, also known as NBOMe-2C-H, is a derivative of the phenethylam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25-NB (psychedelics)
The 25-NB (25''x''-NB''x'') series, or NBOMe series, also known as the ''N''-benzylphenethylamines, is a family of serotonergic psychedelics. They are substituted phenethylamines and were derived from the 2C (psychedelics), 2C family. The most commonly encountered NBOMe drugs are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. The NBOMe drugs act as selective agonists of the serotonin 5-HT2 receptor, 5-HT2 receptors. The 25-NB family is unique relative to other classes of psychedelics in that they are, generally speaking, extremely potency (pharmacology), potent and quite binding selectivity, selective for the 5-HT2 receptors. Use of NBOMe series drugs has caused many deaths and hospitalisations since the drugs popularisation in the 2010s. This is primarily due to their high potency, unpredictable pharmacokinetics, and sellers passing off the compounds in the series as Lysergic acid diethylamide, LSD. Use The 25-NB drugs are inactive oral administration, orally and instead are typically u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
