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2-pyrrolidone
2-Pyrrolidone, also known as 2-pyrrolidinone or butyrolactam, is an organic compound consisting of a 5-membered lactam, making it the simplest γ-lactam. It is a colorless liquid that is miscible with water and most common organic solvents. 2-Pyrrolidone itself and it various derivatives, especially N-methylpyrrolidone, have a variety of industrial uses. Production 2-Pyrrolidone is produced industrially almost exclusively by treating aqueous gamma-butyrolactone with ammonia at a temperature of 250–290 °C and pressures ranging from 0.4–1.4 MPa over solid magnesium silicate catalysts. : The reaction is carried out in a tubular reactor which is packed with the solid catalyst. The latter is arranged as a fixed bed and the reaction is carried out in the vapor phase. Product yields of 75–85% are reached. After subsequent distillation and purification, the desired 2-pyrrolidone is obtained with a purity of 99.5%. Alternative routes include the catalytic or electrochemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vinylpyrrolidone
''N''-Vinylpyrrolidone (NVP) is an organic compound consisting of a 5-membered lactam ring linked to a (2 carbon) vinyl group. It is a colorless liquid although commercial samples can appear yellowish. It is produced industrially by vinylation of 2-Pyrrolidone, 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. It is the precursor to polyvinylpyrrolidone (PVP), an important synthetic material. The NVP monomer is commonly used as a reactive diluent in ultraviolet and electron-Charged particle beam, beam curable polymers applied as inks, coatings or adhesives. Synthesis Starting from Gamma-Butyrolactone, γ-Butyrolactone, 2-pyrrolidone is synthesized by treatment with ammonia. Subsequently, acetylene is used to introduce the vinyl group. See also * Methylpyrrolidone (NMP) * 2-Pyrrolidone (2-Py) References External links N-Vinyl-2-pyrrolidone {{DEFAULTSORT:Vinylpyrrolidone, N- Amide solvents Pyrrolidones Vinyl compounds Monomers Reactive diluents ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Racetam
Racetams, also sometimes known simply as pyrrolidones, are a class of drugs that share a pyrrolidone nucleus. Many, but not all, specifically have a 2- oxo-1- pyrrolidine acetamide (piracetam) nucleus. Some racetams, such as piracetam, aniracetam, oxiracetam, pramiracetam, and phenylpiracetam, are considered nootropics. Phenylpiracetam is also a stimulant. Others, such as levetiracetam, brivaracetam, and seletracetam, are anticonvulsants. Mechanism There is no universally accepted mechanism of action for racetams. Racetams generally show negligible affinity for common central nervous system receptors, but modulation of central neurotransmitters, including acetylcholine and glutamate, has been reported. Although aniracetam and nebracetam show some affinity for muscarinic acetylcholine receptors, only nefiracetam demonstrates nanomolar interactions with neurotransmitter receptors. Modification of membrane-located mechanisms of central signal transduction is another hypothesis. Li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-Pyrrolidone-5-carboxylic Acid
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) is a ubiquitous but understudied natural amino acid derivative in which the free amino group of glutamic acid or glutamine condensation reaction, cyclizes to form a lactam. The names of pyroglutamic acid conjugate base, anion, salt (chemistry), salts, and esters are pyroglutamate, 5-oxoprolinate, or pidolate. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase (ATP-hydrolysing), 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminus, ''N''-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by Glutaminyl-peptide cyclotransferase, glutaminyl cyclases. This is one of several forms of blocked ''N''-termini which present a problem for ''N''-terminal sequencing using Edman degradation, Edman chemistry, which requires a free primary amino group not present in pyroglutami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactam
A lactam is a Cyclic compound, cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words ''lactone'' + ''amide''. Nomenclature Greek_alphabet#Letters, Greek prefixes in alphabetical order indicate ring size. This ring-size nomenclature stems from the fact that hydrolysis of an α-lactam gives an α-amino acid and that of a β-Lactam gives a β-amino acid, and so on. Synthesis General synthetic methods are used for the organic synthesis of lactams. Beckmann rearrangement Lactams form by the Acid catalysis, acid-catalyzed Rearrangement reaction, rearrangement of oximes in the Beckmann rearrangement. Schmidt reaction Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction. Cyclohexanone with hydrazoic acid, forms Caprolactam, ε - Caprolactum, which upon treatment with excess acid forms Pentylenetetrazol, Cardiazole, a heart stimulant. Cyclization of amino acids Lactams can be formed fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-Methylpyrrolidone
''N''-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide. It is used in the petrochemical, polymer and battery industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials (including polyvinylidene difluoride, PVDF). It has a strong dipole moment and hydrogen bonding due to its cis-amide conformation. Preparation NMP is produced industrially by a typical ester-to-amide conversion, by treating gamma-butyrolactone with methylamine. Alternative routes include the partial hydrogenation of ''N''-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis. About 200,000 to 250,000 tons are produced annually. Applications NMP is used to recover ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyvinylpyrrolidone
Polyvinylpyrrolidone (PVP), also commonly called povidone, is a water-soluble polymer compound made from the monomer ''N''-vinylpyrrolidone. PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties. Uses Medical There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications. PVP is a frequently used binder in pharmaceutical tablet formulations. Pharmacokinetic studies in humans and various laboratory animal models indicate no to very little systemic absorption of PVP following oral administration. PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs. It is sold under the trade names Pyodine and Betadine, among others. It is used in pleurodesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hewlett-Packard
The Hewlett-Packard Company, commonly shortened to Hewlett-Packard ( ) or HP, was an American multinational information technology company. It was founded by Bill Hewlett and David Packard in 1939 in a one-car garage in Palo Alto, California, where the company would remain headquartered for the remainder of its lifetime; this HP Garage is now a designated landmark and marked with a plaque calling it the "Birthplace of 'Silicon Valley. HP developed and provided a wide variety of hardware components, as well as software and related services, to consumers, small and medium-sized businesses (small and medium-sized enterprises, SMBs), and fairly large companies, including customers in government sectors, until the company officially split into Hewlett Packard Enterprise and HP Inc. in 2015. HP initially produced a line of electronic test and measurement equipment. It won its first big contract in 1938 to provide the HP 200B, a variation of its first product, the HP 200A low-distor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Succinic Anhydride
Succinic anhydride, is an organic compound with the molecular formula (CH2CO)2O. This colorless solid is the acid anhydride of succinic acid. Preparation In the laboratory, this material can be prepared by dehydration of succinic acid. Such dehydration can occur with the help of acetyl chloride or phosphoryl chloride, or thermally. Industrially, succinic anhydride is prepared by catalytic hydrogenation of maleic anhydride. Reactions Succinic anhydride hydrolyzes readily to give succinic acid: :(CH2CO)2O + H2O → (CH2CO2H)2 With alcohols (ROH), a similar reaction occurs, delivering the monoester: :(CH2CO)2O + ROH → RO2CCH2CH2CO2H Succinic anhydride is used in acylations under Friedel-Crafts conditions, as illustrated by the industrial route to the drug Fenbufen. Related compounds Maleic anhydride undergoes the Alder-ene reaction with alkenes to give alkenylsuccinic anhydrides. Such compounds are sizing agents in the paper industry. In this role, the anhydride is propos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BASF
BASF SE (), an initialism of its original name , is a European Multinational corporation, multinational company and the List of largest chemical producers, largest chemical producer in the world. Its headquarters are located in Ludwigshafen, Germany. BASF comprises subsidiary, subsidiaries and joint ventures in more than 80 countries, operating six integrated production sites and 390 other production sites across Europe, Asia, Australia, the Americas and Africa. BASF has customers in over 190 countries and supplies products to a wide variety of industries. Despite its size and global presence, BASF has received relatively little public attention since it abandoned the manufacture and sale of BASF-branded consumer electronics products in the 1990s. The company began as a dye manufacturer in 1865. Fritz Haber worked with Carl Bosch, one of its employees, to invent the Haber-Bosch, Haber-Bosch process by 1912, after which the company grew rapidly. In 1925, the company merged with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashland Global
Ashland, Inc., is an American chemical company headquartered in Wilmington, Delaware. The company was founded in the city of Ashland, Kentucky, in 1924, where it was headquartered before moving to Wilmington in 1994. The company has five wholly owned divisions, which include Chemical Intermediates and Solvents, Composites, Industrial Specialties, Personal and Home Care, & Pharmaceuticals, Food and Beverage, and Agriculture. Until 2017, the company was the primary manufacturer of Valvoline. History Founding and early years Ashland was founded in 1924 as the Ashland Refining Company in Catlettsburg, Kentucky, by Paul G. Blazer. In October 1923, J. Fred Miles of the Swiss Oil Company of Lexington, Kentucky, employed Paul G. Blazer and assigned him the task of locating, purchasing and operating a refinery in northeastern Kentucky. Blazer selected a location on the banks of the Big Sandy River approximately two miles south of the Ohio River near the community of Leach Railroad Sta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merck Index
''The Merck Index'' is an encyclopedia of chemical substance, chemicals, pharmaceutical drug, drugs and biomolecule, biologicals with over 10,000 monographs on single substances or groups of related chemical compound, compounds published online by the Royal Society of Chemistry. History The first edition of the Merck's Index was published in 1889 by the German chemical company Merck Group, Emanuel Merck and was primarily used as a sales catalog for Merck's growing list of chemicals it sold. The American subsidiary was established two years later and continued to publish it. During World War I the US government seized Merck's US operations and made it a separate American "Merck" company that continued to publish the Merck Index. In 2012 the Merck Index was licensed to the Royal Society of Chemistry. An online version of The Merck Index, including historic records and new updates not in the print edition, is commonly available through research libraries. It also includes an append ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derivative (chemistry)
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction. In the past, derivative also meant a compound that ''can be imagined to'' arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity. The term "structural analogue" is common in organic chemistry. In biochemistry, the word is used for compounds that at least theoretically can be formed from the precursor compound. Chemical derivatives may be used to facilitate analysis. For example, melting point (MP) analysis can assist in identification of many organic compounds. A crystalline derivative may be prepared, such as a semicarbazone or 2,4-dinitrophenylhydrazone (derived from aldehydes or ketones), as a simple way of verifying the identity of the original compound, assuming that a table of derivative MP values is avai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
