|
2-Oxo-PCE
2-Oxo-PCE (also known as ''N''-ethyldeschloroketamine, eticyclidone and O-PCE) is a dissociative anesthetic of the arylcyclohexylamine class that is closely related to deschloroketamine and eticyclidine, and has been sold online as a designer drug. See also * 3-Chloro-PCP * 4-Keto-PCP * Deoxymethoxetamine * MXiPr * Isoethcathinone Isoethcathinone is a designer drug with purportedly stimulant effects, first encountered in Ireland in 2010 and reported to the EMCDDA new drug monitoring service. It is unclear whether it has desirable pharmacological properties in its own right ... References Arylcyclohexylamines Designer drugs Dissociative drugs {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoethcathinone
Isoethcathinone is a designer drug with purportedly stimulant effects, first encountered in Ireland in 2010 and reported to the EMCDDA new drug monitoring service. It is unclear whether it has desirable pharmacological properties in its own right, or is merely an impurity from the synthesis of ethcathinone. See also * Ethcathinone * Filenadol * M-ALPHA M-ALPHA, also known as 3,4-methylenedioxy-α-ethyl-''N''-methylbenzylamine or as α-ethyl-''N''-methylpiperonylamine, is a psychoactive drug of the substituted benzylamine group. It was reported by Alexander Shulgin in his book PIHKAL as a posi ... * 2-Oxo-PCE References Benzylamines Cathinones {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissociative Drug
Dissociatives, colloquially dissos, are a subclass of hallucinogens that distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self. Although many kinds of drugs are capable of such an effect, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include dissociation, a general decrease in sensory experience, hallucinations, dream-like states or anesthesia. Despite most dissociatives' main mechanism of action being tied to NMDA receptor antagonism, some of these substances, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing more ''direct'' and repeatable euphoria or symptoms which are more akin to the effects of typical " hard drugs" or common drugs of abuse. This is likely why dissociatives are considered to be addictive with a fair to moderate potential for abuse, unlike psychedelics. Despite so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anesthesia
Anesthesia (American English) or anaesthesia (British English) is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), amnesia (loss of memory), and unconsciousness. An individual under the effects of anesthetic drugs is referred to as being anesthetized. Anesthesia enables the painless performance of procedures that would otherwise require physical restraint in a non-anesthetized individual, or would otherwise be technically unfeasible. Three broad categories of anesthesia exist: * ''General anesthesia'' suppresses central nervous system activity and results in unconsciousness and total lack of Sensation (psychology), sensation, using either injected or inhaled drugs. * ''Sedation'' suppresses the central nervous system to a lesser degree, inhibiting both anxiolysis, anxiety and creation of long-term memory, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arylcyclohexylamine
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs. History Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not researched by the pharmaceutical industry until the 1950s. PCE was reported in 1953 and PCMo (4-(1-phenyl-cyclohexyl)-morpholine see chart below for figure) in 1954, with PCMo described as a potent sedative. Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 studies of PCP and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its analogues, as illicitly used recreational drugs due to th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deschloroketamine
Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic that has been sold online as a designer drug. It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day. Legal status Deschloroketamine is illegal in Latvia. See also * Ketamine * 2-Fluorodeschloroketamine * 3-Fluorodeschloroketamine * Bromoketamine * Methoxmetamine * Trifluoromethyldeschloroketamine * Rhynchophylline Rhynchophylline is an alkaloid found in certain ''Uncaria'' species (Rubiaceae), notably '' Uncaria rhynchophylla'' and '' Uncaria tomentosa''. It also occurs in the leaves of '' Mitragyna speciosa'' (kratom) and Mitragyna tubulosa, a tree native ... References Arylcyclohexylamines Designer drugs Dissociative drugs Ketones NMDA receptor antagonists {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eticyclidine
PCE (Eticyclidine, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400, but research into PCE was not continued after the development of ketamine, a similar drug with more favourable properties. Due to its similarity in effects to PCP, PCE was placed into the Schedule 1 list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known. See also * Arylcyclohexylamine * 3-MeO-PCE * 3-MeO-PCP * 4-MeO-PCP * Phencyclidine * PCPr * Methoxetamine Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in ... References Arylcyclohex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union, Australia, and New Zealand, as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these designer drugs were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-Chloro-PCP
3-Chloro-PCP (3'-Cl-PCP) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has comparable potency to phencyclidine but with a slightly different effects profile, being somewhat more potent as an NMDA antagonist but around the same potency as a dopamine reuptake inhibitor. It was first identified in Slovenia in December 2020, and was made illegal in Hungary in April 2021. See also * 3-F-PCP * 3-Me-PCP * 3-MeO-PCP * 4-Keto-PCP 4-Keto-PCP is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has potency in between that of ketamine and phencyclidine but with somewhat more sedating effects in animal studies. See also * 3-HO ... References Arylcyclohexylamines Designer drugs Dissociative drugs 3-Chlorophenyl compounds 1-Piperidinyl compounds {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Keto-PCP
4-Keto-PCP is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has potency in between that of ketamine and phencyclidine but with somewhat more sedating effects in animal studies. See also * 3-HO-PCP * 3-Fluoro-PCP * Bromadol * Dimetamine * Methoxetamine Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in ... References Arylcyclohexylamines Designer drugs Dissociative drugs 1-Piperidinyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deoxymethoxetamine
Deoxymethoxetamine (3'-methyl-2-oxo-PCE, DMXE, 3D-MXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is an analogue of methoxetamine where the 3-methoxy group has been replaced by methyl. It has been sold online since around October 2020, and was first definitively identified by a forensic laboratory in Denmark in February 2021. See also * 3-Methyl-PCE * 3-Methyl-PCP * 3-Methyl-PCPy * Hydroxetamine * Fluorexetamine * Methoxetamine * Methoxieticyclidine * MXiPr MXiPr (Methoxisopropamine, Isopropyloxetamine, Isopropyxetamine') is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, related to drugs such as ketamine and methoxetamine. It was first identified in ... References Arylcyclohexylamines Designer drugs Dissociative drugs Secondary amines Ketones {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MXiPr
MXiPr (Methoxisopropamine, Isopropyloxetamine, Isopropyxetamine') is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, related to drugs such as ketamine and methoxetamine. It was first identified in Slovenia in December 2020, and was made illegal in Hungary in April 2021. See also * 3-Methyl-PCP * Deoxymethoxetamine * Fluorexetamine * MDPCP * Methoxpropamine * O-PCE 2-Oxo-PCE (also known as ''N''-ethyldeschloroketamine, eticyclidone and O-PCE) is a dissociative drug, dissociative anesthesia, anesthetic of the arylcyclohexylamine class that is closely related to deschloroketamine and eticyclidine, and has be ... References Arylcyclohexylamines Designer drugs Dissociative drugs 3-Methoxyphenyl compounds Isopropylamino compounds {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arylcyclohexylamines
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical drug, pharmaceutical, designer drug, designer, and experimental drugs. History Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not researched by the pharmaceutical industry until the 1950s. Eticyclidine, PCE was reported in 1953 and PCMo (4-(1-phenyl-cyclohexyl)-morpholine see chart below for figure) in 1954, with PCMo described as a potent sedative. Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 studies of PCP and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its structura ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
