2-Methyltryptamine
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2-Methyltryptamine
2-Methyltryptamine (2-MT, 2-Me-T, or 2-methyl-T) is a serotonin receptor agonist of the substituted tryptamine, tryptamine family. It shows dramatically reduced activity at serotonin receptors compared to tryptamine and mixed effects in terms of head-twitch response, psychedelic-like effects in animals. Pharmacology 2-MT shows affinity (pharmacology), affinity (Ki) for the serotonin 5-HT1A receptor, 5-HT1A and 5-HT2A receptor, 5-HT2A receptors, with Ki values of 1,095nM and 7,774nM, respectively. These affinities were respectively 34-fold and 3.2-fold lower than those of tryptamine in the same study. It also acts as an agonist of the serotonin 5-HT1A and 5-HT2A receptors, with values of 12,534nM and 4,598nM, respectively. These receptor activation, activational potency (pharmacology), potencies were respectively 14-fold and 19-fold lower than those of tryptamine in the same study. It does not produce conditioned place preference (CPP), self-administration, or changes in locomoto ...
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5-Methoxy-2,N,N-trimethyltryptamine
5-Methoxy-2,''N'',''N''-trimethyltryptamine (5-MeO-2,''N'',''N''-TMT, 5-MeO-TMT), also known as 2-methyl-5-methoxy-''N'',''N''-dimethyltryptamine (2-Me-5-MeO-DMT), is a serotonin receptor modulator and psychedelic drug, psychedelic drug of the substituted tryptamine, tryptamine and substituted 2-alkyltryptamine, 2-alkyltryptamine families. It was first chemical synthesis, synthesized by Alexander Shulgin and reported in his 1997 book ''TiHKAL'' (''Tryptamines I Have Known and Loved''). Dosage and effects According to Alexander Shulgin in ''TiHKAL'', 5-MeO-TMT has a dose range of 75 to 150mg oral administration, orally and a duration of action, duration of 5 to 10hours. It produces effects including aphrodisiac, sexual stimulation, enhanced orgasm, mental relaxation, relaxation, sedation, tingling, sleep disturbances, chills and cold sensations, time dilation, reduced heart rate, reduced respiratory rate, mild nausea, motor incoordination, visual waviness, mild to pronounced closed ...
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